Onset and duration of cycloplegic action of 1% cyclopentolate - 1% tropicamide combination

Purpose: To study the time course (onset, time and duration of maximal cycloplegia, and the full duration) of cycloplegic action of 1% Cyclopentolate - 1% Tropicamide. Methods: Seventy-seven students, aged 15-24 years were purposively sampled from the University of Cape Coast and Cape Coast Technica...

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Published in:	African health sciences Vol. 17; no. 3; pp. 923 - 932
Main Authors:	Kyei, Samuel, Nketsiah, Alfred Asiem, Asiedu, Kofi, Awuah, Agnes, Owusu-Ansah, Andrew
Format:	Journal Article
Language:	English
Published:	Uganda Makerere University Medical School 01-09-2017 Makerere Medical School
Subjects:	accommodation Accommodation, Ocular - drug effects Cyclopentolate - administration & dosage Cycloplegia Dose-Response Relationship, Drug Female Humans Male Mydriatics - administration & dosage Ophthalmic Solutions - administration & dosage Pupil - drug effects recovery time time course Time Factors Tropicamide - administration & dosage accommodation time course Cycloplegia recovery time
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Summary:	Purpose: To study the time course (onset, time and duration of maximal cycloplegia, and the full duration) of cycloplegic action of 1% Cyclopentolate - 1% Tropicamide. Methods: Seventy-seven students, aged 15-24 years were purposively sampled from the University of Cape Coast and Cape Coast Technical Institute. Subjective near addition (ADD) determination and pupil diameter measurement before and after a drop of the test agent (1% Cyclopentolate - 1% Tropicamide combination in the right eye) and the control (1% Cyclopentolate in the left eye) were performed. Measurements of subjective near ADD and pupil diameter were made after the initial reading at 5 minutes interval for the first hour and every 30 minutes for the next 7 hours for each participant. Time of onset, time of peak cycloplegia, duration of peak cycloplegia and duration of total cycloplegic effect was indirectly determined. Results: 1% Cyclopentolate - 1% Tropicamide combination had rapid onset of cycloplegia (5-10 minutes), shorter time of maximal cycloplegia (55 versus 90 minutes), and recovery (7 versus ≥ 8hours) in the majority (79.2%) of subjects. Conclusion: Cyclopentolate -Tropicamide combination was comparable to Cyclopentolate in depth of cycloplegia produced, and clinically superior to 1% Cyclopentolate in rapidity of cycloplegic onset, time of maximal cycloplegia and recovery from cycloplegia.
ISSN:	1680-6905 1729-0503 1680-6905
DOI:	10.4314/ahs.v17i3.36