Search Results - "Njuma, Olive J."

The abundant DNA adduct N 7 -methyl deoxyguanosine contributes to miscoding during replication by human DNA polymerase η by Njuma, Olive J, Su, Yan, Guengerich, F Peter

“…Aside from abasic sites and ribonucleotides, the DNA adduct -methyl deoxyguanosine ( -CH dG) is one of the most abundant lesions in mammalian DNA. Because -CH…”
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Mutual synergy between catalase and peroxidase activities of the bifunctional enzyme KatG is facilitated by electron hole-hopping within the enzyme by Njuma, Olive J., Davis, Ian, Ndontsa, Elizabeth N., Krewall, Jessica R., Liu, Aimin, Goodwin, Douglas C.

“…KatG is a bifunctional, heme-dependent enzyme in the front-line defense of numerous bacterial and fungal pathogens against H2O2-induced oxidative damage from…”
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Catalase in peroxidase clothing: Interdependent cooperation of two cofactors in the catalytic versatility of KatG by Njuma, Olive J., Ndontsa, Elizabeth N., Goodwin, Douglas C.

“…•KatG has catalase activity that far exceeds all other members of its superfamily.•KatG uses its heme to post-translationally generate a unique Met-Tyr-Trp…”
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A Role for Catalase-Peroxidase Large Loop 2 Revealed by Deletion Mutagenesis: Control of Active Site Water and Ferric Enzyme Reactivity by Kudalkar, Shalley N, Njuma, Olive J, Li, Yongjiang, Muldowney, Michelle, Fuanta, N. Rene, Goodwin, Douglas C

“…Catalase-peroxidases (KatGs), the only catalase-active members of their superfamily, all possess a 35-residue interhelical loop called large loop 2 (LL2). It…”
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The abundant DNA adduct N7-methyl deoxyguanosine contributes to miscoding during replication by human DNA polymerase η by Njuma, Olive J., Su, Yan, Guengerich, F. Peter

“…Aside from abasic sites and ribonucleotides, the DNA adduct N7-methyl deoxyguanosine (N7-CH3 dG) is one of the most abundant lesions in mammalian DNA. Because…”
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