Search Results - "Njenda, Duncan"

HIV-1 Subtype C with PYxE Insertion Has Enhanced Binding of Gag-p6 to Host Cell Protein ALIX and Increased Replication Fitness by van Domselaar, Robert, Njenda, Duncan T, Rao, Rohit, Sönnerborg, Anders, Singh, Kamalendra, Neogi, Ujjwal

“…Human immunodeficiency virus type 1 subtype C (HIV-1C) has a natural deletion of a YPxL motif in its Gag-p6 late domain. This domain mediates the binding of…”
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Ex-vivo antiretroviral potency of newer integrase strand transfer inhibitors cabotegravir and bictegravir in HIV type 1 non-B subtypes by Neogi, Ujjwal, Singh, Kamalendra, Aralaguppe, Shambhu G, Rogers, Leonard C, Njenda, Duncan T, Sarafianos, Stefan G, Hejdeman, Bo, Sönnerborg, Anders

“…OBJECTIVE:To determine the antiretroviral activity of the integrase strand transfer inhibitors (INSTIs), raltegravir (RAL), elvitegravir (EVG), dolutegravir…”
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Antiretroviral potency of 4'-ethnyl-2'-fluoro-2'-deoxyadenosine, tenofovir alafenamide and second-generation NNRTIs across diverse HIV-1 subtypes by Njenda, Duncan T, Aralaguppe, Shambhu G, Singh, Kamalendra, Rao, Rohit, Sönnerborg, Anders, Sarafianos, Stefan G, Neogi, Ujjwal

“…4'-Ethnyl-2'-fluoro-2'-deoxyadenosine (EFdA) is a novel translocation-defective reverse transcriptase inhibitor. We investigated the virological and…”
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Strain-specific effect on biphasic DNA binding by HIV-1 integrase by Hill, Kyle J, Rogers, Leonard C, Njenda, Duncan T, Burke, Donald H, Sarafianos, Stefan G, Sönnerborg, Anders, Neogi, Ujjwal, Singh, Kamalendra

“…The oligomerization of HIV-1 integrase onto DNA is not well understood. Here we show that HIV-1 integrase binds the DNA in biphasic (high-affinity and…”
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Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts by Alim, M Abdul, Njenda, Duncan, Lundmark, Anna, Kaminska, Marta, Jansson, Leif, Eriksson, Kaja, Kats, Anna, Johannsen, Gunnar, Arvidsson, Catalin Koro, Mydel, Piotr M, Yucel-Lindberg, Tülay

“…Chronic periodontitis (CP) is a bacteria-driven inflammatory disease characterized by the breakdown of gingival tissue, the periodontal ligament, and alveolar…”
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Ex vivo antiretroviral potency of newer integrase strand transfer inhibitors cabotegravir and bictegravir in HIV-1 non-B subtypes by NEOGI, Ujjwal, SINGH, Kamlendra, ARALAGUPPE, Shambhu G, ROGERS, Leonard C., NJENDA, Duncan T, SARAFIANOS, Stefan G., HEJDEMAN, Bo, SÖNNERBORG, Anders

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HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon by Mikasi, Sello Given, Gichana, Josiah Otwoma, Van der Walt, Cheri, Brado, Dominik, Obasa, Adetayo Emmanuel, Njenda, Duncan, Messembe, Martha, Lyonga, Emilia, Assoumou, Okomo, Cloete, Ruben, Ikomey, George Mondinde, Jacobs, Graeme Brendon

“…The World Health Organization (WHO) has put forth recommendations for the use of integrase (IN) strand transfer inhibitors (INSTIs) to be part of the…”
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From Bedside to Bench and Back: Future Options for Antiretroviral Drugs in Non-B HIV-1 Subtypes by Njenda, Duncan Tazvinzwa

“…HIV-1 drug resistance remains a burden in low- and middle-income countries (LMIC).Regardless of the advances in antiretroviral (ARV) therapy, there is an…”
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Observed HIV drug resistance associated mutations amongst naïve immunocompetent children in Yaoundé, Cameroon by Ikomey, George Mondinde, Assoumou, Marie Claire Okomo, Gichana, Josiah Otwoma, Njenda, Duncan, Mikasi, Sello Given, Mesembe, Martha, Lyonga, Emilia, Jacobs, Graeme Brendon

“…The emergence of drug resistance mutations (DRMs) has been a major threat for successful lifelong combination antiretroviral therapy (cART), especially for…”
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