Search Results - "Njajou, Omer T"

Association Between Telomere Length, Specific Causes of Death, and Years of Healthy Life in Health, Aging, and Body Composition, a Population-Based Cohort Study by Njajou, Omer T., Hsueh, Wen-Chi, Blackburn, Elizabeth H., Newman, Anne B., Wu, Shih-Hsuan, Li, Rongling, Simonsick, Eleanor M., Harris, Tamara M., Cummings, Steve R., Cawthon, Richard M.

“…Although telomere length (TL) is known to play a critical role in cellular senescence, the relationship of TL to aging and longevity in humans is not well…”
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Telomere length is paternally inherited and is associated with parental lifespan by Njajou, Omer T, Cawthon, Richard M, Damcott, Coleen M, Wu, Shih-Hsuan, Ott, Sandy, Garant, Michael J, Blackburn, Elizabeth H, Mitchell, Braxton D, Shuldiner, Alan R, Hsueh, Wen-Chi

“…Telomere length (TL) is emerging as a biomarker for aging and survival. To evaluate factors influencing this trait, we measured TL in a large homogeneous…”
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Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study by Njajou, Omer T., Kanaya, Alka M., Holvoet, Paul, Connelly, Stephanie, Strotmeyer, Elsa S., Harris, Tamara B., Cummings, Steve R., Hsueh, Wen-Chi

“…Background Accumulating evidence suggests a cross‐sectional association between oxidative stress and type 2 diabetes (T2D). Systemic oxidative stress, as…”
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IHR-PVS National Bridging Workshop in Cameroon: An interactive and participatory approach to engage stakeholders in the development of a One Health road map by Ndoungué, Viviane Fossouo, Bello, Djamilla, Kameni, Jean Marc Feussom, Lamtoing, Antoine Damou, Epee, Christian Emmanuel Douba, Abdou, Salla, Mouliom, Mohamed Moctar Mouiche, Njajou, Omer T., Tieblé, Traoré, Wango, Roland Kimbi, Belot, Guillaume, Kouadio, Serge Agbo, de La Rocque, Stéphane

“…Stakeholders involved in the implementation of the One Health (OH) welcome support for the operationalization of the approach and advice on how to address OH…”
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Reproducibility of peroneal motor nerve conduction measurement in older adults by Ward, Rachel E, Boudreau, Robert M, Vinik, Aaron I, Zivkovic, Sasa A, Njajou, Omer T, Satterfield, Suzanne, Harris, Tamara B, Newman, Anne B, Strotmeyer, Elsa S

“…Highlights ► Motor nerve conduction reproducibility is poorly established in very old adults, despite a high burden of sensorimotor decline and overt…”
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A common variant in the telomerase RNA component is associated with short telomere length by Njajou, Omer T, Blackburn, Elizabeth H, Pawlikowska, Ludmila, Mangino, Massimo, Damcott, Coleen M, Kwok, Pui-Yan, Spector, Timothy D, Newman, Anne B, Harris, Tamara B, Cummings, Steven R, Cawthon, Richard M, Shuldiner, Alan R, Valdes, Ana M, Hsueh, Wen-Chi

“…Telomeres shorten as cells divide. This shortening is compensated by the enzyme telomerase. We evaluated the effect of common variants in the telomerase RNA…”
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Habitual sleep/wake patterns in the Old Order Amish: heritability and association with non-genetic factors by Evans, Daniel S, Snitker, Soren, Wu, Shih-Hsuan, Mody, Aaloke, Njajou, Omer T, Perlis, Michael L, Gehrman, Philip R, Shuldiner, Alan R, Hsueh, Wen-Chi

“…We sought to evaluate the contribution of genetic and non-genetic factors on habitual sleep/wake patterns in a community-dwelling agrarian population using a…”
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A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis by Njajou, Omer T, Vaessen, Norbert, Joosse, Marijke, Berghuis, Bianca, van Dongen, Jeroen W.F, Breuning, Martijn H, Snijders, Pieter J.L.M, Rutten, Wim P.F, Sandkuijl, Lodewijk A, Oostra, Ben A, van Duijn, Cornelia M, Heutink, Peter

“…Hereditary hemochromatosis (HH) is a very common disorder characterized by iron overload and multi-organ damage. Several genes involved in iron metabolism have…”
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Dominant Hemochromatosis Due to N144H Mutation of SLC11A3: Clinical and Biological Characteristics by Njajou, Omer T., de Jong, Gerard, Berghuis, Bianca, Vaessen, Norbert, Snijders, Pieter J.L.M., Goossens, Jan P., Wilson, John H.P., Breuning, Martijn H., Oostra, Ben A., Heutink, Peter, Sandkuijl, Lodewijk A., van Duijn, Cornelia M.

“…ABSTRACT Hereditary hemochromatosis is classically inherited as a recessive trait but is genetically heterogeneous. Mutations in the HFE and the TFR2 genes…”
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The −514 C→T Hepatic Lipase Promoter Region Polymorphism and Plasma Lipids: A Meta-Analysis by Isaacs, Aaron, Sayed-Tabatabaei, Fakhredin A., Njajou, Omer T., Witteman, Jacqueline C. M., van Duijn, Cornelia M.

“…Investigations of the −514 C→T single nucleotide polymorphism (SNP) in the hepatic lipase (HL) gene promoter region (LIPC) have yielded contradictory results…”
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Replication and Extension of Association Between Common Genetic Variants in SIM1 and Human Adiposity by Swarbrick, Michael M., Evans, Daniel S., Valle, Maria. I., Favre, Hélène, Wu, Shi‐Hsuan, Njajou, Omer T., Li, Rongling, Zmuda, Joseph M., Miljkovic, Iva, Harris, Tamara B., Kwok, Pui‐Yan, Vaisse, Christian, Hsueh, Wen‐Chi

“…Haplo‐insufficiency of the bHLH (basic helix‐loop‐helix) transcription factor single‐minded 1 (SIM1) causes severe obesity in mice and humans. We hypothesized…”
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Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism by Dekker, Marieke C.J, Giesbergen, Patricia C, Njajou, Omer T, van Swieten, John C, Hofman, Albert, Breteler, Monique M.B, van Duijn, Cornelia M

“…Iron overload increases oxidative stress and may lead to neurodegenerative disease like Parkinson's disease (PD). We studied the role of mutations in the…”
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HFE gene mutations increase the risk of coronary heart disease in women by Pardo Silva, M. Carolina, Njajou, Omer T, Alizadeh, Behrooz Z, Hofman, Albert, Witteman, Jacqueline C. M, van Duijn, Cornelia M, Janssens, A. Cecile J. W

“…The purpose of the present study is to examine HFE gene mutations in relation to newly diagnosed (incident) coronary heart disease (CHD). In a population-based…”
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An Insulin-Like Growth Factor-I Promoter Polymorphism Is Associated With Increased Mortality in Subjects With Myocardial Infarction in an Elderly Caucasian Population by Yazdanpanah, Mojgan, Rietveld, Ingrid, Janssen, Joop A.M.J.L., Njajou, Omer T., Hofman, Albert, Stijnen, Theo, Pols, Huibert A.P., Lamberts, Steven W.J., Witteman, Jacqueline C.M., van Duijn, Cornelia M.

“…We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial…”
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A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism by NJAJOU, Omer T, HOUWING-DUISTERMAAT, Jeanine J, OSBORNE, Richard H, VAESSEN, Norbert, VERGEER, Jeanette, HEERINGA, Jan, POLS, Huibert A. P, HOFMAN, Albert, VAN DUIJN, Cornelia M

“…The C282Y and H63D mutations in the HFE gene are important causes of hemochromatosis. In the elderly, these mutations might be associated with increased…”
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The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population by Sutedja, Nadia A, Sinke, Richard J, Van Vught, Paul W J, Van der Linden, Michiel W, Wokke, John H J, Van Duijn, Cornelia M, Njajou, Omer T, Van der Schouw, Yvonne T, Veldink, Jan H, Van den Berg, Leonard H

“…Mutations in HFE, a gene defect that can disrupt iron metabolism, have been implicated in increasing the risk of developing amyotrophic lateral sclerosis…”
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Mutations in the hemochromatosis gene (HFE) and stroke by NJAJOU, Omer T, HOLLANDER, Monika, KOUDSTAAL, Peter J, HOFMAN, Albert, WITTEMAN, Jacqueline C. M, BRETELER, Monique M. B, VAN DUIJN, Cornelia M

“…Increased serum iron is found to be a risk factor for stroke. Carriers of HFE C282Y and H63D mutations have elevated serum iron levels and may have an…”
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Is Genetic Screening for Hemochromatosis Worthwhile? by Njajou, Omer T., Alizadeh, Behrooz Z., van Duijn, Cornelia M.

“…Hereditary hemochromatosis is an iron overload disorder and is the most common recessive disease in Caucasians. About 80% of hemochromatosis patients are…”
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The role of hemochromatosis C282Y and H63D gene mutations in type 2 diabetes: findings from the Rotterdam Study and meta-analysis by Njajou, Omer T, Alizadeh, Behrooz Z, Vaessen, Norbert, Vergeer, Jeannete, Houwing-Duistermaat, Jeannine, Hofman, Albert, Pols, Huibert A P, Van Duijn, Cornelia M

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The Hemochromatosis N144H Mutation of SLC11A3 Gene in Patients with Type 2 Diabetes by Njajou, Omer T., Vaessen, Norbert, Oostra, Ben, Heutink, Peter, Van Duijn, Cornelia M.

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