Study of IL-33 and IL-1R4 in Iraqi rheumatoid arthritis female patient's with and without dyslipidemia prone to atherosclerosis

This study is planned to find relationship between interleukin-33 (IL-33) with its receptor interleukin-1 receptor 4 (IL-1R4), and assurance IL-33/IL-1R4 proportion as biomarker to atherosclerosisin rheumatoid arthritis (RA) Iraqi female’s patients with and without dyslipidemia. this study was attem...

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Bibliographic Details
Published in:	Ibn Al-Haitham Journal for Pure and Applied Sciences Vol. 32; no. 1; pp. 48 - 56
Main Authors:	Nizar, Lara Ali, Abbas, Iman A. A.
Format:	Journal Article
Language:	English
Published:	Baghdad, Iraq University of Baghdad, College of Education for Pure Science / Ibn al-Haitham 2019 University of Baghdad
Subjects:	Rheumatoid arthritis, IL-33, IL-1R4, atherosclerosis disease, ESR and RF التصلب العصيدي التهاب المفاصل الروماتويدي المرأة المرضى المضاعفات عسر شحميات الدم
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Summary:	This study is planned to find relationship between interleukin-33 (IL-33) with its receptor interleukin-1 receptor 4 (IL-1R4), and assurance IL-33/IL-1R4 proportion as biomarker to atherosclerosisin rheumatoid arthritis (RA) Iraqi female’s patients with and without dyslipidemia. this study was attempted at Baghdad teaching hospital included 60 female’s patients with ra that were isolated into: 30 patients with dyslipidemia(G2), 30 patients without dyslipidemia(G3) and 30 individuals as control group (G1). Patients were experiencing treatment by methortexiene medication, analyzed by rheumatoid factor (RF) and erythrocyte sedimentation rate (ESR) tests. All patients and control groups age ranged from(30-55) years. The results show an increase in ESR, RF, IL-33, and IL-1R4 levels. In addition to decrease in IL-33/IL-1R4 ratio in the two patient’s groups when contrasted and control group. The momentum examine inferred that the level of ESR, and IL-33 in RA Iraqi females patients with dyslipidemia were higher than that in RA Iraqi females patients without dyslipidemia, while the level of IL-33/IL-1R4 ratio in RA Iraqi females patients with dyslipidemia was lower than that in RA Iraqi females patients without dyslipidemia patients ; in this manner the IL-33/IL-1R4 ratio may be used as a biomarker in diagnostic early porn to atherosclerosis in RA females patients with dyslipidemia.
ISSN:	1609-4042 2521-3407
DOI:	10.30526/32.1.1920