Search Results - "Nizam, Rasheeba"

Role of Caveolin-1 in Diabetes and Its Complications by Al-Mulla, Fahd, Nizam, Rasheeba, Al Madhoun, Ashraf, Haddad, Dania

“…It is estimated that in 2017 there were 451 million people with diabetes worldwide. These figures are expected to increase to 693 million by 2045; thus,…”
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Identification of Maturity-Onset-Diabetes of the Young (MODY) mutations in a country where diabetes is endemic by Al-Kandari, Hessa, Al-Abdulrazzaq, Dalia, Davidsson, Lena, Nizam, Rasheeba, Jacob, Sindhu, Melhem, Motasem, John, Sumi Elsa, Al-Mulla, Fahd

“…Genetic variants responsible for Maturity-Onset-Diabetes of the Young (MODY) in Kuwait were investigated. A newly established a National Referral Clinic, the…”
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SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains by Haddad, Dania, John, Sumi Elsa, Mohammad, Anwar, Hammad, Maha M, Hebbar, Prashantha, Channanath, Arshad, Nizam, Rasheeba, Al-Qabandi, Sarah, Al Madhoun, Ashraf, Alshukry, Abdullah, Ali, Hamad, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly…”
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Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells by Al Madhoun, Ashraf, Haddad, Dania, Al Tarrah, Mustafa, Jacob, Sindhu, Al-Ali, Waleed, Nizam, Rasheeba, Miranda, Lavina, Al-Rashed, Fatema, Sindhu, Sardar, Ahmad, Rasheed, Bitar, Milad S., Al-Mulla, Fahd

“…The imipramine ONC201 has antiproliferative effects in several cancer cell types and activates integrated stress response pathway associated with the induction…”
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Reduced miR-181d level in obesity and its role in lipid metabolism via regulation of ANGPTL3 by Abu-Farha, Mohamed, Cherian, Preethi, Al-Khairi, Irina, Nizam, Rasheeba, Alkandari, Abdullah, Arefanian, Hossein, Tuomilehto, Jaakko, Al-Mulla, Fahd, Abubaker, Jehad

“…Obesity impacts the endocrine and metabolic functions of the adipose tissue. There is increasing interest in the role of epigenetic factors in obesity and its…”
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Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families by Hebbar, Prashantha, Nizam, Rasheeba, John, Sumi Elsa, Antony, Dinu, Dashti, Mohammad, Channanath, Arshad, Shaltout, Azza, Al-Khandari, Hessa, Koistinen, Heikki A., Tuomilehto, Jaakko, Alsmadi, Osama, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…Type 1 diabetes (T1D) is characterized by the progressive destruction of pancreatic β-cells, leading to insulin deficiency and lifelong dependency on exogenous…”
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Association between alleles, haplotypes, and amino acid variations in HLA class II genes and type 1 diabetes in Kuwaiti children by Dashti, Mohammed, Nizam, Rasheeba, Jacob, Sindhu, Al-Kandari, Hessa, Al Ozairi, Ebaa, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…Type 1 diabetes (T1D) is a complex autoimmune disorder that is highly prevalent globally. The interactions between genetic and environmental factors may…”
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HLA-B allele frequencies and implications for pharmacogenetics in the Kuwaiti population by Dashti, Mohammed, Malik, Md Zubbair, Al-Matrouk, Abdullah, Bhatti, Saeeda, Nizam, Rasheeba, Jacob, Sindhu, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…This study explores the frequency of human leukocyte antigen (HLA) genes, particularly alleles, within the Kuwaiti population. We aim to identify alleles with…”
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Differentially methylated and expressed genes in familial type 1 diabetes by Dashti, Mohammed, Nizam, Rasheeba, Hebbar, Prashantha, Jacob, Sindhu, John, Sumi Elsa, Channanath, Arshad, Al-Kandari, Hessa, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…There has recently been a growing interest in examining the role of epigenetic modifications, such as DNA methylation, in the etiology of type 1 diabetes…”
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Evaluation of HLA typing content of next-generation sequencing datasets from family trios and individuals of arab ethnicity by Dashti, Mohammed, Malik, Md Zubbair, Nizam, Rasheeba, Jacob, Sindhu, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…HLA typing is a critical tool in both clinical and research applications at the individual and population levels. Benchmarking studies have indicated HLA-HD as…”
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Mitochondrial haplogroup R offers protection against obesity in Kuwaiti and Qatari populations by Dashti, Mohammed, Ali, Naser M, Alsaleh, Hussain, John, Sumi Elsa, Nizam, Rasheeba, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…The Kuwaiti and Qatari populations have a high prevalence of obesity, a major risk factor for various metabolic disorders. Previous studies have independently…”
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Global analysis of urinary extracellular vesicle small RNAs in autosomal dominant polycystic kidney disease by Ali, Hamad, Malik, Md. Zubbair, Abu‐Farha, Mohamed, Abubaker, Jehad, Cherian, Preethi, Nizam, Rasheeba, Jacob, Sindhu, Bahbahani, Yousif, Naim, Medhat, Ahmad, Sajjad, Al‐Sayegh, Mohammad, Thanaraj, Thangavel Alphonse, Ong, Albert C. M., Harris, Peter C., Al‐Mulla, Fahd

“…Background Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent monogenic renal disease progressing to end‐stage renal disease. There is…”
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Circulating hsa-miR-320a and its regulatory network in type 1 diabetes mellitus by Nizam, Rasheeba, Malik, Md Zubbair, Jacob, Sindhu, Alsmadi, Osama, Koistinen, Heikki A, Tuomilehto, Jaakko, Alkandari, Hessa, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Increasing evidence from human and animal model studies indicates the significant role of microRNAs (miRNAs) in pancreatic beta cell function, insulin…”
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ONECUT1 variants beyond type 1 and type 2 diabetes: exploring clinical diversity and epigenetic associations in Arab cohorts by Dashti, Mohammed, Nizam, Rasheeba, John, Sumi Elsa, Melhem, Motasem, Channanath, Arshad, Alkandari, Hessa, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…gene, encoding hepatocyte nuclear factor 6, is involved in pancreas and liver development. mutations impair the function of pancreatic β-cells and control a…”
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Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population by Hebbar, Prashantha, Nizam, Rasheeba, Melhem, Motasem, Alkayal, Fadi, Elkum, Naser, John, Sumi Elsa, Tuomilehto, Jaakko, Alsmadi, Osama, Thanaraj, Thangavel Alphonse

“…Abnormal blood lipid levels are influenced by genetic and lifestyle/dietary factors. Although many genetic variants associated with blood lipid traits have…”
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Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin by AlKhairi, Irina, Cherian, Preethi, Abu-Farha, Mohamed, Madhoun, Ashraf Al, Nizam, Rasheeba, Melhem, Motasem, Jamal, Mohamed, Al-Sabah, Suleiman, Ali, Hamad, Tuomilehto, Jaakko, Al-Mulla, Fahd, Abubaker, Jehad

“…Type 2 diabetes (T2D) is a growing pandemic associated with metabolic dysregulation and chronic inflammation. Meteorin-like hormone (METRNL) is an adipomyokine…”
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Caveolin-1 rs1997623 variant and adult metabolic syndrome—Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians by Al Madhoun, Ashraf, Hebbar, Prashantha, Nizam, Rasheeba, Haddad, Dania, Melhem, Motasem, Abu-Farha, Mohamed, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…Background: Animal and cell model studies have implicated CAV1 in the pathophysiology of metabolic disorders. Our previous studies demonstrated a potential…”
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Early autoantibody screening for type 1 diabetes: a Kuwaiti perspective on the advantages of multiplexing chemiluminescent assays by Al-Mulla, Fahd, Alhomaidah, Doha, Abu-Farha, Mohamed, Hasan, Amal, Al-Khairi, Irina, Nizam, Rasheeba, Alqabandi, Rawan, Alkandari, Hessa, Abubaker, Jehad

“…Type 1 diabetes (T1D) incidence has increased globally over the last decades, alongside other autoimmune diseases. Early screening of individuals at risk of…”
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Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population by Hebbar, Prashantha, Abu-Farha, Mohamed, Alkayal, Fadi, Nizam, Rasheeba, Elkum, Naser, Melhem, Motasem, John, Sumi Elsa, Channanath, Arshad, Abubaker, Jehad, Bennakhi, Abdullah, Al-Ozairi, Ebaa, Tuomilehto, Jaakko, Pitkaniemi, Janne, Alsmadi, Osama, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Consanguineous populations of the Arabian Peninsula, which has seen an uncontrolled rise in type 2 diabetes incidence, are underrepresented in global studies…”
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Soybean oil-based HFD induces gut dysbiosis that leads to steatosis, hepatic inflammation and insulin resistance in mice by Jacob, Texy, Sindhu, Sardar, Hasan, Amal, Malik, Md Zubbair, Arefanian, Hossein, Al-Rashed, Fatema, Nizam, Rasheeba, Kochumon, Shihab, Thomas, Reeby, Bahman, Fatemah, Shenouda, Steve, Wilson, Ajit, Akther, Nadeem, Al-Roub, Areej, Abukhalaf, Nermeen, Albeloushi, Shaima, Abu-Farha, Mohamed, Al Madhoun, Ashraf, Alzaid, Fawaz, Thanaraj, Thangavel Alphonse, Koistinen, Heikki A, Tuomilehto, Jaakko, Al-Mulla, Fahd, Ahmad, Rasheed

“…High-fat diets (HFDs) shape the gut microbiome and promote obesity, inflammation, and liver steatosis. Fish and soybean are part of a healthy diet; however,…”
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