Search Results - "Nixon, Ralph A"

The role of autophagy in neurodegenerative disease by Nixon, Ralph A

“…This Review provides an overview of the role of autophagy, a key lysosomal degradative process, in neurodegenerative diseases. The study of various…”
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Amyloid precursor protein and endosomal‐lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease by Nixon, Ralph A.

“…ABSTRACT Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of Alzheimer's disease (AD). These include the earliest known…”
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Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies by Yuan, Aidong, Nixon, Ralph A.

“…Biomarkers of neurodegeneration and neuronal injury have the potential to improve diagnostic accuracy, disease monitoring, prognosis, and measure treatment…”
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Autophagy, amyloidogenesis and Alzheimer disease by Nixon, Ralph A

“…Autophagy is the sole pathway for organelle turnover in cells and is a vital pathway for degrading normal and aggregated proteins, particularly under stress or…”
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Disorders of lysosomal acidification—the emerging role of v-ATPase in aging and neurodegenerative disease by Colacurcio, Daniel J, Nixon, Ralph A

“…Highlights • pH regulates hydrolytic, signaling, and homeostatic functions of lysosomes. • The v-ATPase complex is mainly responsible for lysosomal…”
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Neurofilaments and Neurofilament Proteins in Health and Disease by Yuan, Aidong, Rao, Mala V, Veeranna, Nixon, Ralph A

“…SUMMARYNeurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments (IFs) in being heteropolymers composed of four subunits (NF-L…”
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Lysosome trafficking and signaling in health and neurodegenerative diseases by Lie, Pearl P.Y., Nixon, Ralph A.

“…Lysosomes, single-membrane organelles defined by a uniquely strong acidic lumenal pH and high content of acid hydrolases, are the shared degradative…”
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Autophagy failure in Alzheimer's disease—locating the primary defect by Nixon, Ralph A, Yang, Dun-Sheng

“…Abstract Autophagy, the major degradative pathway for organelles and long-lived proteins, is essential for the survival of neurons. Mounting evidence has…”
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Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy by Lee, Sooyeon, Sato, Yutaka, Nixon, Ralph A

“…In the hallmark neuritic dystrophy of Alzheimer's disease (AD), autophagic vacuoles containing incompletely digested proteins selectively accumulate in focal…”
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Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease by Colacurcio, Daniel J., Pensalfini, Anna, Jiang, Ying, Nixon, Ralph A.

“…Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer's Disease (AD), largely owing to a triplication of the APP gene, located on…”
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Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime by McBrayer, MaryKate, Nixon, Ralph A

“…Early-onset FAD (familial Alzheimer's disease) is caused by mutations of PS1 (presenilin 1), PS2 (presenilin 2) and APP (amyloid precursor protein). Beyond the…”
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Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy by Bordi, Matteo, Berg, Martin J., Mohan, Panaiyur S., Peterhoff, Corrinne M., Alldred, Melissa J., Che, Shaoli, Ginsberg, Stephen D., Nixon, Ralph A.

“…Defective autophagy contributes to Alzheimer disease (AD) pathogenesis although evidence is conflicting on whether multiple stages are impaired. Here, for the…”
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Neurofilaments: neurobiological foundations for biomarker applications by Gafson, Arie R, Barthélemy, Nicolas R, Bomont, Pascale, Carare, Roxana O, Durham, Heather D, Julien, Jean-Pierre, Kuhle, Jens, Leppert, David, Nixon, Ralph A, Weller, Roy O, Zetterberg, Henrik, Matthews, Paul M

“…Interest in neurofilaments has risen sharply in recent years with recognition of their potential as biomarkers of brain injury or neurodegeneration in CSF and…”
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Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification by Wolfe, Devin M., Lee, Ju-hyun, Kumar, Asok, Lee, Sooyeon, Orenstein, Samantha J., Nixon, Ralph A.

“…Autophagy is a lysosomal degradative process which recycles cellular waste and eliminates potentially toxic damaged organelles and protein aggregates. The…”
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A gene toolbox for monitoring autophagy transcription by Bordi, Matteo, De Cegli, Rossella, Testa, Beatrice, Nixon, Ralph A., Ballabio, Andrea, Cecconi, Francesco

“…Autophagy is a highly dynamic and multi-step process, regulated by many functional protein units. Here, we have built up a comprehensive and up-to-date…”
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Amyloid-independent mechanisms in Alzheimer's disease pathogenesis by Pimplikar, Sanjay W, Nixon, Ralph A, Robakis, Nikolaos K, Shen, Jie, Tsai, Li-Huei

“…Despite the progress of the past two decades, the cause of Alzheimer's disease (AD) and effective treatments against it remain elusive. The hypothesis that…”
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Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases by Nixon, Ralph A.

“…Endocytosis is universally important in cell function. In the brain, the roles of endosomes are relatively more complex due to the unique polar morphology of…”
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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations by Lee, Ju-Hyun, Yu, W. Haung, Kumar, Asok, Lee, Sooyeon, Mohan, Panaiyur S., Peterhoff, Corrinne M., Wolfe, Devin M., Martinez-Vicente, Marta, Massey, Ashish C., Sovak, Guy, Uchiyama, Yasuo, Westaway, David, Cuervo, Ana Maria, Nixon, Ralph A.

“…Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease…”
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Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come by Alam, John J, Nixon, Ralph A

“…Keywords: Cholinergic degeneration, Basal forebrain, Rab5, Neflamapimod, p38[alpha], Alzheimer's disease, Dementia with Lewy bodies…”
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Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification by Lee, Ju-Hyun, McBrayer, Mary Kate, Wolfe, Devin M., Haslett, Luke J., Kumar, Asok, Sato, Yutaka, Lie, Pearl P.Y., Mohan, Panaiyur, Coffey, Erin E., Kompella, Uday, Mitchell, Claire H., Lloyd-Evans, Emyr, Nixon, Ralph A.

“…Presenilin 1 (PS1) deletion or Alzheimer’s disease (AD)-linked mutations disrupt lysosomal acidification and proteolysis, which inhibits autophagy. Here, we…”
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