Search Results - "Nixon, R A"

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity by Menzies, F M, Garcia-Arencibia, M, Imarisio, S, O'Sullivan, N C, Ricketts, T, Kent, B A, Rao, M V, Lam, W, Green-Thompson, Z W, Nixon, R A, Saksida, L M, Bussey, T J, O'Kane, C J, Rubinsztein, D C

“…Over recent years, accumulated evidence suggests that autophagy induction is protective in animal models of a number of neurodegenerative diseases. Intense…”
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Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease by Yu, W.H., Kumar, A., Peterhoff, C., Shapiro Kulnane, L., Uchiyama, Y., Lamb, B.T., Cuervo, A.M., Nixon, R.A.

“…In Alzheimer’s disease (AD), the neuropathologic hallmarks of β-amyloid deposition and neurofibrillary degeneration are associated with early and progressive…”
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Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations by CATALDO, A. M, PETERHOFF, C. M, TRONCOSO, J. C, GOMEZ-ISLA, T, HYMAN, B. T, NIXON, R. A

“…Endocytosis is critical to the function and fate of molecules important to Alzheimer's disease (AD) etiology, including the beta protein precursor (betaPP),…”
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Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease by Kim, S, Sato, Y, Mohan, P S, Peterhoff, C, Pensalfini, A, Rigoglioso, A, Jiang, Y, Nixon, R A

“…β-Amyloid precursor protein (APP) and its cleaved products are strongly implicated in Alzheimer’s disease (AD). Endosomes are highly active APP processing…”
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Functions of neurofilaments in synapses by Yuan, A, Sershen, H, Veeranna, Basavarajappa, B S, Kumar, A, Hashim, A, Berg, M, Lee, J-H, Sato, Y, Rao, M V, Mohan, P S, Dyakin, V, Julien, J-P, Lee, V M-Y, Nixon, R A

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Autophagy and neuronal cell death in neurological disorders by Nixon, Ralph A, Yang, Dun-Sheng

“…Autophagy is implicated in the pathogenesis of major neurodegenerative disorders although concepts about how it influences these diseases are still evolving…”
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Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease by Boland, Barry, Kumar, Asok, Lee, Sooyeon, Platt, Frances M, Wegiel, Jerzy, Yu, W. Haung, Nixon, Ralph A

“…Macroautophagy, a major pathway for organelle and protein turnover, has been implicated in the neurodegeneration of Alzheimer's disease (AD). The basis for the…”
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Widespread Activation of Calcium-Activated Neutral Proteinase (Calpain) in the Brain in Alzheimer Disease: A Potential Molecular Basis for Neuronal Degeneration by Saito, Ken-Ichi, Elce, John S., Hamos, James E., Nixon, Ralph A.

“…Calcium-activated neutral proteinases (CANPs or calpains) are believed to be key enzymes in intracellular signaling cascades and potential mediators of calcium…”
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Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer’s disease by Adamec, E, Mohan, P.S, Cataldo, A.M, Vonsattel, J.P, Nixon, R.A

“…Previous studies established that the populations of neurons that frequently degenerate in Alzheimer’s disease exhibit robust up-regulation of the lysosomal…”
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APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome by LAI, F, KAMMANN, E, REBECK, G. W, ANDERSON, A, CHEN, Y, NIXON, R. A

“…Alzheimer disease (AD) neuropathology is present in Down syndrome (DS) after age 35, but dementia onset varies from ages 40 to 70 years. Because of small…”
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DNA strand breaks in Alzheimer's disease by Adamec, Emil, Vonsattel, Jean Paul, Nixon, Ralph A.

“…The goal of this study was to investigate the presence of DNA damage in Alzheimer's disease (AD) utilizing independent assays for three different types of DNA…”
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Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy by Rothenberg, Cara, Srinivasan, Deepa, Mah, Leann, Kaushik, Susmita, Peterhoff, Corrine M., Ugolino, Janet, Fang, Shengyun, Cuervo, Ana Maria, Nixon, Ralph A., Monteiro, Mervyn J.

“…Autophagy is the process by which organelles and portions of the cytoplasm are degraded in lysosomes. Several different forms of autophagy are known that are…”
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Phosphorylation on Carboxyl Terminus Domains of Neurofilament Proteins in Retinal Ganglion Cell Neurons in vivo: Influences on Regional Neurofilament Accumulation, Interneurofilament Spacing, and Axon Caliber by Nixon, Ralph A., Paskevich, Peter A., Sihag, Ram K., Thayer, Christina Y.

“…The high molecular weight subunits of neurofilaments, NF-H and NF-M, have distinctively long carboxyl-terminal domains that become highly phosphorylated after…”
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Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice by Rao, Mala V, McBrayer, Mary Kate, Campbell, Jabbar, Kumar, Asok, Hashim, Audrey, Sershen, Henry, Stavrides, Philip H, Ohno, Masuo, Hutton, Michael, Nixon, Ralph A

“…Tau pathogenicity in Alzheimer's disease and other tauopathies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau…”
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Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo by Yuan, A, Sershen, H, Veeranna, Basavarajappa, B S, Kumar, A, Hashim, A, Berg, M, Lee, J-H, Sato, Y, Rao, M V, Mohan, P S, Dyakin, V, Julien, J-P, Lee, V M-Y, Nixon, R A

“…Synaptic roles for neurofilament (NF) proteins have rarely been considered. Here, we establish all four NF subunits as integral resident proteins of synapses…”
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Enzymatically Active Lysosomal Proteases are Associated with Amyloid Deposits in Alzheimer Brain by Cataldo, Anne M., Nixon, Ralph A.

“…The formation of β-amyloid in the brains of individuals with Alzheimer disease requires the proteolytic cleavage of a membrane-associated precursor protein…”
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The endosomal-lysosomal system of neurons: new roles by Nixon, Ralph A., Cataldo, Anne M.

“…The repertoire of the lysosomal system extends beyond its function in degrading biologic macromolecules for energy and recycling purposes. Controlled shifts in…”
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Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons by Yuan, Aidong, Sasaki, Takahiro, Kumar, Asok, Peterhoff, Corrinne M, Rao, Mala V, Liem, Ronald K, Julien, Jean-Pierre, Nixon, Ralph A

“…Peripherin, a neuronal intermediate filament protein implicated in neurodegenerative disease, coexists with the neurofilament triplet proteins [neurofilament…”
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Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease by Cataldo, AM, Hamilton, DJ, Barnett, JL, Paskevich, PA, Nixon, RA

“…Specific antibodies and cytochemical markers combined with several imaging and morphometric techniques were used to characterize the endosomal-lysosomal system…”
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Lysosomal Hydrolases of Different Classes are Abnormally Distributed in Brains of Patients with Alzheimer Disease by CATALDO, A. M, PASKEVICH, P. A, KOMINAMI, E, NIXON, R. A

“…β-Amyloid formation requires multiple abnormal proteolytic cleavages of amyloid precursor protein (APP), including one within its intramembrane domain…”
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