Search Results - "Nixon, Peter F"

Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein by Jones, Martina L, Nixon, Peter F

“…The dietary supply of folates and their measurement are both affected, potentially, by the instability of some folates. Labile folates appear to be stabilized…”
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Quantitative description of the interaction between folate and the folate-binding protein from cow's milk by Nixon, Peter F, Jones, Marc, Winzor, Donald J

“…A detailed study has been carried out on the dependence of folate binding on the concentration of FBP (folate-binding protein) at pH 5.0, conditions selected…”
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Glutamate Export at the Choroid Plexus in Health, Thiamin Deficiency, and Ethanol Intoxication: Review and Hypothesis by Nixon, Peter F.

“…Introduction:  The earliest observed effect in the pathogenesis of experimental Wernicke’s encephalopathy and of ethanol intoxication in rats is impairment of…”
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Choroid Plexus Dysfunction: The Initial Event in the Pathogenesis of Wernicke's Encephalopathy and Ethanol Intoxication by Nixon, Peter F., Jordan, Lindsay, Zimitat, Craig, Rose, Stephen E., Zelaya, Fernando

“…Background:  In both acute ethanol intoxication and in thiamin deficient glucose metabolism, previous studies have detected blood‐brain barrier (BBB) and/or…”
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Thiamin nutrition and catalysis-induced instability of thiamin diphosphate by McCourt, Jennifer A., Nixon, Peter F., Duggleby, Ronald G.

“…Thiamin (vitamin B1) is required in animal diets because it is the precursor of the enzyme cofactor, thiamin diphosphate. Unlike other B vitamins, the dietary…”
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Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats by Jones, Martina L, Treloar, Tony, Nixon, Peter F

“…The newborns of mammals have a high folate demand, yet obtain adequate folate nutrition solely from their mothers' milk despite its low folate content. Milk…”
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Glucose induced IEG expression in the thiamin-deficient rat brain by Zimitat, Craig, Nixon, Peter F

“…Glucose loading of rats made thiamin deficient by dietary deprivation of thiamin and the administration of pyrithiamin (40 μg/100 g, i.p.) precipitates an…”
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Effects of Deletions at the Carboxyl Terminus of Zymomonas mobilis Pyruvate Decarboxylase on the Kinetic Properties and Substrate Specificity by Chang, Alan K, Nixon, Peter F, Duggleby, Ronald G

“…The three-dimensional structure of Zymomonas mobilis pyruvate decarboxylase shows that the carboxyl-terminal region of the protein occludes the active site…”
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Glucose loading precipitates acute encephalopathy in thiamin-deficient rats by ZIMITAT, C, NIXON, P. F

“…A rat model of glucose-precipitated Wernicke's encephalopathy (WE) has been developed in which glucose loading (10 g/kg, i.p.) of ataxic thiamin-deficient (TD)…”
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Molecular evolutionary analysis of the thiamine-diphosphate-dependent enzyme, transketolase by Schenk, G. (The University of Queensland, St. Lucia, QLD, Australia.), Layfield, R, Candy, J.M, Duggleby, R.G, Nixon, P.F

“…Members of the transketolase group of thiamine-diphosphate-dependent enzymes from 17 different organisms including mammals, yeast, bacteria, and plants have…”
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Heterologous expression of human transketolase by Schenk, Gerhard, Duggleby, Ronald G, Nixon, Peter F

“…Transketolase belongs to the family of thiamin diphosphate dependent enzymes. The aim of this study was to establish a bacterial expression system for human…”
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Changes in the hippocampus induced by glucose in thiamin deficient rats detected by MRI by Jordan, Lindsay R, Zelaya, Fernando O, Rose, Stephen E, Bower, Adrian J, Galloway, Graham, Wholohan, Therese, Nixon, Peter F

“…Using T 2-weighted Magnetic Resonance Imaging (MRI) in a pyrithiamin-treated, thiamin deficient (TD) rat model of Wernicke's encephalopathy (WE), we have…”
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Effective absorption and utilization of oral formyltetrahydrofolate in man by Nixon, P F, Bertino, J R

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High control coefficient of transketolase in the nonoxidative pentose phosphate pathway of human erythrocytes: NMR, antibody, and computer simulation studies by Berthon, Hilary A, Kuchel, Philip W, Nixon, Peter F

“…The degree of control exerted by transketolase over metabolite flux in the nonoxidative pentose phosphate pathway in human erythrocytes was investigated using…”
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Site‐directed mutagenesis of the ionizable groups in the active site of Zymomonas mobilis pyruvate decarboxylase by Huang, Chang‐Yi, Chang, Alan K., Nixon, Peter F., Duggleby, Ronald G.

“…Pyruvate decarboxylase (PDC, EC 4.1.1.1) is a thiamin diphosphate‐dependent enzyme about which there is a large body of structural and functional information…”
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Modulation of pteroylpolyglutamate concentration and length in response to altered folate nutrition in a comprehensive range of rat tissues by Ward, G J, Nixon, P F

“…For a range of rat tissue extracts, the concentrations of total folates and of short-chain pteroylpolyglutamates were assayed by Lactobacillus casei with and…”
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Properties and functions of the thiamin diphosphate dependent enzyme transketolase by Schenk, Gerhard, Duggleby, Ronald G., Nixon, Peter F.

“…This review highlights recent research on the properties and functions of the enzyme transketolase, which requires thiamin diphosphate and a divalent metal ion…”
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Glucose induced IEG expression in the thiamin-deficient rat brain11Published on the World Wide Web 3 January 2001 by Zimitat, Craig, Nixon, Peter F

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The Turnover of Folate Coenzymes in Murine Lymphoma Cells by Nixon, Peter F., Slutsky, Gerald, Nahas, Aly, Bertino, Joseph R.

“…To estimate the turnover of 5-CH3-H4-folate in murine lymphoma cells L1210, L1210R (a methotrexate-resistant subline), and L5178Y, suspensions of whole cells…”
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Aspartate-27 and glutamate-473 are involved in catalysis by Zymomonas mobilis pyruvate decarboxylase by CHANG, Alan K., NIXON, Peter F., DUGGLEBY, Ronald G.

“…Zymomonas mobilis pyruvate decarboxylase (EC 4.1.1.1) was subjected to site-directed mutagenesis at two acidic residues near the thiamin diphosphate cofactor…”
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