Search Results - "Nixon, Kevin C J"

Mushroom Body Specific Transcriptome Analysis Reveals Dynamic Regulation of Learning and Memory Genes After Acquisition of Long-Term Courtship Memory in Drosophila by Jones, Spencer G, Nixon, Kevin C J, Chubak, Melissa C, Kramer, Jamie M

“…The formation and recall of long-term memory (LTM) requires neuron activity-induced gene expression. Transcriptome analysis has been used to identify genes…”
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Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers by Patel, Parasvi S, Algouneh, Arash, Krishnan, Rehna, Reynolds, John J, Nixon, Kevin C J, Hao, Jun, Lee, Jihoon, Feng, Yue, Fozil, Chehronai, Stanic, Mia, Yerlici, Talya, Su, Peiran, Soares, Fraser, Liedtke, Elisabeth, Prive, Gil, Baider, Gary D, Pujana, Miquel Angel, Mekhail, Karim, He, Housheng Hansen, Hakem, Anne, Stewart, Grant S, Hakem, Razqallah

“…Abstract BRCA1 mutations are associated with increased breast and ovarian cancer risk. BRCA1-mutant tumors are high-grade, recurrent, and often become…”
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Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the Drosophila mushroom body by Chubak, Melissa C, Nixon, Kevin C J, Stone, Max H, Raun, Nicholas, Rice, Shelby L, Sarikahya, Mohammed, Jones, Spencer G, Lyons, Taylor A, Jakub, Taryn E, Mainland, Roslyn L M, Knip, Maria J, Edwards, Tara N, Kramer, Jamie M

“…Technology has led to rapid progress in the identification of genes involved in neurodevelopmental disorders such as intellectual disability (ID), but our…”
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Targeting the Ubiquitin-Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer by Majeed, Safa, Aparnathi, Mansi K, Nixon, Kevin C J, Venkatasubramanian, Vidhyasagar, Rahman, Fariha, Song, Lifang, Weiss, Jessica, Barayan, Ranya, Sugumar, Vijithan, Barghout, Samir H, Pearson, Joel D, Bremner, Rod, Schimmer, Aaron D, Tsao, Ming S, Liu, Geoffrey, Lok, Benjamin H

“…Small cell lung cancer (SCLC) is an aggressive disease with an overall 5-year survival rate of less than 10%. Treatment for SCLC with cisplatin/etoposide…”
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Proteinase-Activated Receptor 4 Activation Triggers Cell Membrane Blebbing through RhoA and β -Arrestin by Vanderboor, Christina M G, Thibeault, Pierre E, Nixon, Kevin C J, Gros, Robert, Kramer, Jamie, Ramachandran, Rithwik

“…Proteinase-activated receptors (PARs) are a four-member family of G-protein-coupled receptors that are activated via proteolysis. PAR4 is a member of this…”
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RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells by Krishnan, Rehna, Lapierre, Mariah, Gautreau, Brandon, Nixon, Kevin C J, El Ghamrasni, Samah, Patel, Parasvi S, Hao, Jun, Yerlici, V Talya, Guturi, Kiran Kumar Naidu, St-Germain, Jonathan, Mateo, Francesca, Saad, Amine, Algouneh, Arash, Earnshaw, Rebecca, Shili, Duan, Seitova, Alma, Miller, Joshua, Khosraviani, Negin, Penn, Adam, Ho, Brandon, Sanchez, Otto, Hande, M Prakash, Masson, Jean-Yves, Brown, Grant W, Alaoui-Jamali, Moulay, Reynolds, John J, Arrowsmith, Cheryl, Raught, Brian, Pujana, Miguel A, Mekhail, Karim, Stewart, Grant S, Hakem, Anne, Hakem, Razqallah

“…Abstract Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies, including PARP inhibitors. Given the lack of effective…”
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A Syndromic Neurodevelopmental Disorder Caused by Mutations in SMARCD1, a Core SWI/SNF Subunit Needed for Context-Dependent Neuronal Gene Regulation in Flies by Nixon, Kevin C.J., Rousseau, Justine, Stone, Max H., Sarikahya, Mohammed, Ehresmann, Sophie, Mizuno, Seiji, Matsumoto, Naomichi, Miyake, Noriko, Baralle, Diana, McKee, Shane, Izumi, Kosuke, Ritter, Alyssa L., Heide, Solveig, Héron, Delphine, Depienne, Christel, Titheradge, Hannah, Kramer, Jamie M., Campeau, Philippe M.

“…Mutations in several genes encoding components of the SWI/SNF chromatin remodeling complex cause neurodevelopmental disorders (NDDs). Here, we report on five…”
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Extracellular Heparan 6- O -Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies by Yang, Yang, Ahn, Jaeil, Edwards, Nathan J, Benicky, Julius, Rozeboom, Aaron M, Davidson, Bruce, Karamboulas, Christina, Nixon, Kevin C J, Ailles, Laurie, Goldman, Radoslav

“…Pan-cancer analysis of TCGA and CPTAC (proteomics) data shows that SULF1 and SULF2 are oncogenic in a number of human malignancies and associated with poor…”
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Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy by Farhan, Sali M K, Nixon, Kevin C J, Everest, Michelle, Edwards, Tara N, Long, Shirley, Segal, Dmitri, Knip, Maria J, Arts, Heleen H, Chakrabarti, Rana, Wang, Jian, Robinson, John F, Lee, Donald, Mirsattari, Seyed M, Rupar, C Anthony, Siu, Victoria M, Poulter, Michael O, Hegele, Robert A, Kramer, Jamie M

“…Defects in neuronal migration cause brain malformations, which are associated with intellectual disability (ID) and epilepsy. Using exome sequencing, we…”
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Extracellular Heparan 6-IO/I-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies by Yang, Yang, Ahn, Jaeil, Edwards, Nathan J, Benicky, Julius, Rozeboom, Aaron M, Davidson, Bruce, Karamboulas, Christina, Nixon, Kevin C. J, Ailles, Laurie, Goldman, Radoslav

“…6-O-endosulfatases, SULF1 and SULF2, are oncogenic in multiple malignancies and are associated with poor survival outcomes. SULF1 is one of the most…”
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Mushroom Body-Specific Gene Regulation by the SWI/SNF Chromatin Remodeling Complex by Nixon, Kevin C. J

“…Over the lifetime of an organism, neurons must establish, remodel, and maintain precise connections in order to form neural circuits that are required for…”
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Targeting the ubiquitin-proteasome system using the UBA1 inhibitor TAK-243 is a potential therapeutic strategy for small cell lung cancer by Majeed, Safa, Aparnathi, Mansi K, Nixon, Kevin C J, Venkatasubramanian, Vidhyasagar, Rahman, Fariha, Song, Lifang, Weiss, Jessica, Barayan, Ranya, Sugumar, Vijithan, Barghout, Samir H, Pearson, Joel D, Bremner, Rod, Schimmer, Aaron D, Tsao, Ming S, Liu, Geoffrey, Lok, Benjamin H

“…Small cell lung cancer (SCLC) is an aggressive disease with an overall five-year survival rate of <10%. Treatment for SCLC with cisplatin/etoposide…”
Get full text