Search Results - "Nix, A."

Reprogramming the Maternal Zebrafish Genome after Fertilization to Match the Paternal Methylation Pattern by Potok, Magdalena E., Nix, David A., Parnell, Timothy J., Cairns, Bradley R.

“…Early vertebrate embryos must achieve totipotency and prepare for zygotic genome activation (ZGA). To understand this process, we determined the DNA…”
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Distinctive chromatin in human sperm packages genes for embryo development by Carrell, Douglas T, Cairns, Bradley R, Hammoud, Saher Sue, Nix, David A, Zhang, Haiying, Purwar, Jahnvi

“…Because nucleosomes are widely replaced by protamine in mature human sperm, the epigenetic contributions of sperm chromatin to embryo development have been…”
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Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons by Hendrickson, Peter G, Doráis, Jessie A, Grow, Edward J, Whiddon, Jennifer L, Lim, Jong-Won, Wike, Candice L, Weaver, Bradley D, Pflueger, Christian, Emery, Benjamin R, Wilcox, Aaron L, Nix, David A, Peterson, C Matthew, Tapscott, Stephen J, Carrell, Douglas T, Cairns, Bradley R

“…Bradley Cairns, Douglas Carrell, Stephen Tapscott and colleagues transcriptionally profile human oocytes and preimplantation embryos and highlight DUX4-family…”
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Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 by Glasgow, Anum, Glasgow, Jeff, Limonta, Daniel, Solomon, Paige, Lui, Irene, Zhang, Yang, Nix, Matthew A., Rettko, Nicholas J., Zha, Shoshana, Yamin, Rachel, Kao, Kevin, Rosenberg, Oren S., Ravetch, Jeffrey V., Wiita, Arun P., Leung, Kevin K., Lim, Shion A., Zhou, Xin X., Hobman, Tom C., Kortemme, Tanja, Wells, James A.

“…An essential mechanism for severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Potential role for snoRNAs in PKR activation during metabolic stress by Youssef, Osama A., Safran, Sarah A., Nakamura, Takahisa, Nix, David A., Hotamisligil, Gökhan S., Bass, Brenda L.

“…Protein kinase RNA-activated (PKR) has long been known to be activated by viral double-stranded RNA (dsRNA) as part of the mammalian immune response. However,…”
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Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes by Rowley, Jesse W., Oler, Andrew J., Tolley, Neal D., Hunter, Benjamin N., Low, Elizabeth N., Nix, David A., Yost, Christian C., Zimmerman, Guy A., Weyrich, Andrew S.

“…Inbred mice are a useful tool for studying the in vivo functions of platelets. Nonetheless, the mRNA signature of mouse platelets is not known. Here, we use…”
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The generational impact of household clutter by Nix, Caitlyn A., Dozier, Mary E.

“…Objectives Hoarding disorder can create long‐term problems for adult children of individuals with hoarding symptoms; however, the extent of the psychosocial…”
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RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription by Kapranov, Philipp, Cheng, Jill, Dike, Sujit, Nix, David A., Duttagupta, Radharani, Willingham, Aarron T., Stadler, Peter F., Hertel, Jana, Hackermüller, Jörg, Hofacker, Ivo L., Bell, Ian, Cheung, Evelyn, Drenkow, Jorg, Dumais, Erica, Patel, Sandeep, Helt, Gregg, Ganesh, Madhavan, Ghosh, Srinka, Piccolboni, Antonio, Sementchenko, Victor, Tammana, Hari, Gingeras, Thomas R.

“…Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated and has reduced protein-coding potential. The genomic origins and…”
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Benzodiazepines: Uses, Dangers, and Clinical Considerations by Edinoff, Amber N., Nix, Catherine A., Hollier, Janice, Sagrera, Caroline E., Delacroix, Blake M., Abubakar, Tunde, Cornett, Elyse M., Kaye, Adam M., Kaye, Alan D.

“…Benzodiazepines (BZDs) are among one of the most widely prescribed drug classes in the United States. BZDs are a class of psychoactive drugs known for their…”
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The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance by Ferguson, Ian D., Patiño-Escobar, Bonell, Tuomivaara, Sami T., Lin, Yu-Hsiu T., Nix, Matthew A., Leung, Kevin K., Kasap, Corynn, Ramos, Emilio, Nieves Vasquez, Wilson, Talbot, Alexis, Hale, Martina, Naik, Akul, Kishishita, Audrey, Choudhry, Priya, Lopez-Girona, Antonia, Miao, Weili, Wong, Sandy W., Wolf, Jeffrey L., Martin, Thomas G., Shah, Nina, Vandenberg, Scott, Prakash, Sonam, Besse, Lenka, Driessen, Christoph, Posey, Avery D., Mullins, R. Dyche, Eyquem, Justin, Wells, James A., Wiita, Arun P.

“…The myeloma surface proteome (surfaceome) determines tumor interaction with the microenvironment and serves as an emerging arena for therapeutic development…”
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Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men by Hammoud, Saher Sue, Nix, David A., Hammoud, Ahmad O., Gibson, Mark, Cairns, Bradley R., Carrell, Douglas T.

“…BACKGROUND The sperm chromatin of fertile men retains a small number of nucleosomes that are enriched at developmental gene promoters and imprinted gene loci…”
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Antiparallel β-Sheet Structure within the C-Terminal Region of 42-Residue Alzheimer's Amyloid-β Peptides When They Form 150-kDa Oligomers by Huang, Danting, Zimmerman, Maxwell I., Martin, Patricia K., Nix, A.Jeremy, Rosenberry, Terrone L., Paravastu, Anant K.

“…Understanding the molecular structures of amyloid-β (Aβ) oligomers and underlying assembly pathways will advance our understanding of Alzheimer's disease (AD)…”
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Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks by Nix, David A, Courdy, Samir J, Boucher, Kenneth M

“…High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone…”
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Automated size selection for short cell-free DNA fragments enriches for circulating tumor DNA and improves error correction during next generation sequencing by Hellwig, Sabine, Nix, David A, Gligorich, Keith M, O'Shea, John M, Thomas, Alun, Fuertes, Carrie L, Bhetariya, Preetida J, Marth, Gabor T, Bronner, Mary P, Underhill, Hunter R

“…Circulating tumor-derived cell-free DNA (ctDNA) enables non-invasive diagnosis, monitoring, and treatment susceptibility testing in human cancers. However,…”
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Genome-wide analysis of Polycomb targets in Drosophila melanogaster by Pirrotta, Vincenzo, Nix, David A, Biggin, Mark, Bourgon, Richard, Li, Xiao-Yong, Kahn, Tatyana G, Schwartz, Yuri B

“…Polycomb group (PcG) complexes are multiprotein assemblages that bind to chromatin and establish chromatin states leading to epigenetic silencing. PcG proteins…”
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Vibration–based structural damage identification by Farrar, Charles R., Doebling, Scott W., Nix, David A.

“…Many aerospace, civil and mechanical systems continue to be used despite ageing and the associated potential for damage accumulation. Therefore, the ability to…”
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Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinoma by Affolter, Kajsa E., Hellwig, Sabine, Nix, David A., Bronner, Mary P., Thomas, Alun, Fuertes, Carrie L., Hamil, Cindy L., Garrido-Laguna, Ignacio, Scaife, Courtney L., Mulvihill, Sean J., Underhill, Hunter R.

“…The confounding effects of next-generation sequencing (NGS) noise on detection of low frequency circulating tumor DNA (ctDNA) without a priori knowledge of…”
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4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores by Obeid, Rima, Geisel, Juergen, Nix, Wilfred A

“…Vascular diseases are multifactorial and several risk factors may have synergetic effect on the global vascular risk. Among patients with diabetes, we…”
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The stochastic nature of errors in next-generation sequencing of circulating cell-free DNA by Nix, David A, Hellwig, Sabine, Conley, Christopher, Thomas, Alun, Fuertes, Carrie L, Hamil, Cindy L, Bhetariya, Preetida J, Garrido-Laguna, Ignacio, Marth, Gabor T, Bronner, Mary P, Underhill, Hunter R

“…Challenges with distinguishing circulating tumor DNA (ctDNA) from next-generation sequencing (NGS) artifacts limits variant searches to established solid tumor…”
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Genome-wide profiling of the C. elegans dsRNAome by Whipple, Joseph M, Youssef, Osama A, Aruscavage, P Joseph, Nix, David A, Hong, Changjin, Johnson, W Evan, Bass, Brenda L

“…Recent studies hint that endogenous dsRNA plays an unexpected role in cellular signaling. However, a complete understanding of endogenous dsRNA signaling is…”
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