Search Results - "Niwa, Satomi"
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Structure of the LH1–RC complex from Thermochromatium tepidum at 3.0 Å
Published in Nature (London) (10-04-2014)“…The light-harvesting core antenna (LH1) and the reaction centre (RC) of purple photosynthetic bacteria form a supramolecular complex (LH1–RC) to use sunlight…”
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Downregulation of Ca2+-activated Cl- channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing cancer cells
Published in The Journal of pharmacology and experimental therapeutics (01-12-2014)“…The Ca(2+)-activated Cl(-) channel transmembrane proteins with unknown function 16 A (TMEM16A; also known as anoctamin 1 or discovered on gastrointestinal…”
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Defective splicing of the background K+ channel K2P5.1 by the pre-mRNA splicing inhibitor, pladienolide B in lectin-activated mouse splenic CD4+ T cells
Published in Journal of pharmacological sciences (01-11-2016)“…The two-pore domain K+ channel K2P5.1 has been implicated in the pathogenesis of autoimmune diseases. We investigated the changes in K2P5.1 activity caused by…”
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Detailed analysis of distorted retinal and its interaction with surrounding residues in the K intermediate of bacteriorhodopsin
Published in Communications biology (17-02-2023)“…The K intermediate of proton pumping bacteriorhodopsin is the first intermediate generated after isomerization of retinal to the 13- cis form. Although various…”
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Down-Regulation of Ca2+-Activated K+ Channel KCa1.1 in Human Breast Cancer MDA-MB-453 Cells Treated with Vitamin D Receptor Agonists
Published in International journal of molecular sciences (11-12-2016)“…Vitamin D (VD) reduces the risk of breast cancer and improves disease prognoses. Potential VD analogs are being developed as therapeutic agents for breast…”
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Crystallographic characterization of the high-potential iron-sulfur protein in the oxidized state at 0.8 Å resolution
Published in PloS one (22-05-2017)“…High-potential iron-sulfur protein (HiPIP) is a soluble electron carrier protein of photosynthetic bacteria with an Fe4S4 cluster. Although structural changes…”
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Structure of a putative immature form of a Rieske-type iron-sulfur protein in complex with zinc chloride
Published in Communications chemistry (09-09-2023)“…Iron-sulfur clusters are prosthetic groups of proteins involved in various biological processes. However, details of the immature state of the iron-sulfur…”
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Malignancy Grade–Dependent Expression of K+-Channel Subtypes in Human Prostate Cancer
Published in Journal of Pharmacological Sciences (01-01-2009)“…K+ channels are key molecules in the progression of several cancer types and considered to be potential targets for cancer therapy. We examined the gene…”
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Transcriptional Repression and Protein Degradation of the Ca2+-Activated K+ Channel KCa1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells
Published in Frontiers in physiology (16-04-2018)“…The large-conductance Ca 2+ -activated K + channel K Ca 1.1 plays an important role in the promotion of breast cancer cell proliferation and metastasis. The…”
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10
Bumblebee commercialization will cause worldwide migration of parasitic mites
Published in Molecular ecology (01-08-2001)“…We investigated natural populations of three Japanese native bumblebee species to determine the status of infestation by a tracheal mite, Locustacarus…”
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Down-Regulation of the Large-Conductance Ca2+-Activated K+ Channel, KCa1.1 in the Prostatic Stromal Cells of Benign Prostate Hyperplasia
Published in Biological & pharmaceutical bulletin (01-05-2012)“…Large-conductance Ca2+-activated K+ (BKCa) channel encoded by KCa1.1 plays an important role in the control of smooth muscle tone by modulating membrane…”
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Intermediate-conductance Ca2+-activated K+ channel, KCa3.1, as a novel therapeutic target for benign prostatic hyperplasia
Published in The Journal of pharmacology and experimental therapeutics (01-08-2011)“…Recently, a new experimental stromal hyperplasia animal model corresponding to clinical benign prostatic hyperplasia (BPH) was established. The main objective…”
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Involvement of Dominant-negative Spliced Variants of the Intermediate Conductance Ca2+-activated K+ Channel, KCa3.1, in Immune Function of Lymphoid Cells
Published in The Journal of biological chemistry (01-05-2011)“…The intermediate conductance Ca2+-activated K+ channel (IKCa channel) encoded by KCa3.1 is responsible for the control of proliferation and differentiation in…”
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Downregulation of the Ca2+‐activated K+ channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells
Published in Pharmacology research & perspectives (01-04-2016)“…The intermediate‐conductance Ca2+‐activated K+ channel KCa3.1 is involved in the promotion of tumor growth and metastasis, and is a potential therapeutic…”
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Anti‐proliferative effect of Ca 2+ ‐activated K + channel K Ca 2.2 blocker in prostate cancer LNCaP cells
Published in The FASEB journal (01-04-2020)“…Abstract only Androgen receptors (AR) are essential for the growth of prostate cancer (PC) cells. Androgen deprivation (castration) therapy as antiandrogens is…”
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Crystal structure of heme A synthase from Bacillus subtilis
Published in Proceedings of the National Academy of Sciences - PNAS (20-11-2018)“…Heme A is an essential cofactor for respiratory terminal oxidases and vital for respiration in aerobic organisms. The final step of heme A biosynthesis is…”
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Transcriptional repression of HER2 by ANO1 Cl− channel inhibition in human breast cancer cells with resistance to trastuzumab
Published in Biochemical and biophysical research communications (01-01-2017)“…The Ca2+-activated Cl− channel ANO1 contributes to tumorigenesis and metastasis in several carcinomas including breast cancer (BCA). Cl− channels have recently…”
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Usefulness of oils for cleaning the host matrix and for cryoprotection of lipidic cubic phase crystals
Published in Journal of applied crystallography (01-08-2019)“…The lipidic cubic phase method is an effective approach for membrane protein crystallography. The in meso grown crystals are usually cryocooled directly…”
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Crystal structures of chitin binding domains of chitinase from Thermococcus kodakarensis KOD1
Published in FEBS letters (01-01-2016)“…Chitinase from T. kodakarensis (TkChiA) catalyzes the hydrolysis of chitin. The enzyme consists of two catalytic and three binding domains (ChBD1, ChBD2 and…”
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EMDB—the Electron Microscopy Data Bank
Published in Nucleic acids research (05-01-2024)“…Abstract The Electron Microscopy Data Bank (EMDB) is the global public archive of three-dimensional electron microscopy (3DEM) maps of biological specimens…”
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