Search Results - "Niu, Tianhui"
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Crystal structure of the FTO protein reveals basis for its substrate specificity
Published in Nature (London) (22-04-2010)“…Recent studies have unequivocally associated the fat mass and obesity-associated (FTO) gene with the risk of obesity. In vitro FTO protein is an AlkB-like…”
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2
Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin
Published in PloS one (18-09-2015)“…Curcumin is a widely known natural phytochemical from plant Curcuma longa. In recent years, curcumin has received increasing attention because of its…”
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3
Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3 Lysine 27 Methylation
Published in Science (American Association for the Advancement of Science) (24-08-2012)“…Polycomb repressive complex 2 (PRC2)—mediated histone H3 lysine 27 (H3K27) methylation is vital for Polycomb gene silencing, a classic epigenetic phenomenon…”
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4
Inhibition of Autophagy Enhances Curcumin United light irradiation-induced Oxidative Stress and Tumor Growth Suppression in Human Melanoma Cells
Published in Scientific reports (09-08-2016)“…Malignant melanoma is the most aggressive form of skin carcinoma, which possesses fast propagating and highly invasive characteristics. Curcumin is a natural…”
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5
Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)
Published in Journal of medicinal chemistry (24-09-2015)“…N-(5-Chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide (N-CDPCB, 1a) is found to be an inhibitor of the fat mass and obesity associated protein (FTO)…”
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6
H2AX phosphorylation regulated by p38 is involved in Bim expression and apoptosis in chronic myelogenous leukemia cells induced by imatinib
Published in Apoptosis (London) (01-08-2014)“…Increasing evidence suggests that histone H2AX plays a critical role in regulation of tumor cell apoptosis and acts as a novel human tumor suppressor protein…”
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7
Genome-wide transcriptional analysis of apoptosis-related genes and pathways regulated by H2AX in lung cancer A549 cells
Published in Apoptosis (London) (01-09-2013)“…Histone H2AX is a novel tumor suppressor protein and plays an important role in apoptosis of cancer cells. However, the role of H2AX in lung cancer cells is…”
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Inhibition of ROS-NF-κB-dependent autophagy enhances Hypocrellin A united LED red light-induced apoptosis in squamous carcinoma A431 cells
Published in Cellular signalling (01-05-2020)“…Cutaneous squamous cell carcinoma (cSCC) is a type of malignant skin tumor derived from epidermal Malpighian cells. Photodynamic therapy is regarded as a…”
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9
Sirtuin 3 controls cardiac energetics and protects against oxidative stress in electromagnetic radiation-induced cardiomyopathy
Published in Free radical biology & medicine (20-08-2023)“…Electromagnetic radiation can cause injuries to both the structures and functions of the heart. No therapy is currently available to inhibit these untoward…”
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10
Key mechanistic features of the trade-off between antibody escape and host cell binding in the SARS-CoV-2 Omicron variant spike proteins
Published in The EMBO journal (16-04-2024)“…Since SARS-CoV-2 Omicron variant emerged, it is constantly evolving into multiple sub-variants, including BF.7, BQ.1, BQ.1.1, XBB, XBB.1.5 and the recently…”
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Abstract 2342: Related study on the fat mass and obesity associated FTO gene and melanoma
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract FTO is a Fe(II)/2-oxoglutarate-dependent oxidative DNA/RNA demethylase and plays a key role in the fat metabolism and several chronic illnesses…”
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12
Antifibrotic effects of Hypocrellin A combined with LED red light irradiation on keloid fibroblasts by counteracting the TGF-β/Smad/autophagy/apoptosis signalling pathway
Published in Photodiagnosis and photodynamic therapy (01-06-2021)“…•HA combined with red light irradiation treatment could suppress KFs hyperproliferation, collagen synthesis and ECM accumulation.•HA-R-PDT could regulate KFs…”
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13
Red Light Interferes in UVA-Induced Photoaging of Human Skin Fibroblast Cells
Published in Photochemistry and photobiology (01-11-2014)“…The possible regulation mechanism of red light was determined to discover how to retard UVA‐induced skin photoaging. Human skin fibroblasts were cultured and…”
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14
Abstract 341: Imatinib induces expression of Bim and apoptosis in chronic myelogenous leukemia cells via p38/H2AX pathway
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract H2AX is a novel human tumor suppressor protein and plays an important role in apoptosis of cancer cells. Increasing published data indicate that H2AX…”
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15
The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability
Published in RNA (Cambridge) (01-12-2007)“…Formation of transcription-induced R-loops poses a critical threat to genomic integrity throughout evolution. We have recently shown that the SR protein…”
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Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20
Published in Scientific reports (08-07-2015)“…Malignant gliomas are the most common malignant tumors in the central nervous system (CNS). Up to date, the prognosis of glioma is still very poor, effective…”
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Effect of serum from healthy individuals on the growth of melanocytes in vitro following moxibustion at the “Jiudianfeng” point
Published in Journal of international medical research (01-03-2020)“…Objective To investigate the effects of serum from healthy individuals obtained following moxibustion at the “Jiudianfeng” point on melanocytes in vitro…”
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18
The Injury and Cumulative Effects on Human Skin by UV Exposure from Artificial Fluorescence Emission
Published in Photochemistry and photobiology (01-11-2014)“…The injury and cumulative effects of UV emission from fluorescence lamp were studied. UV intensity from fluorescence lamp was measured, and human skin samples…”
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Effect of serum from healthy individuals on the growth of melanocytes following moxibustion at the “Jiudianfeng” point
Published in Journal of international medical research (01-03-2020)“…Objective To investigate the effects of serum from healthy individuals obtained following moxibustion at the “Jiudianfeng” point on melanocytes in vitro …”
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20
A loop matters for FTO substrate selection
Published in Protein & cell (01-07-2010)“…Recent studies have unequivocally established the link between FTO and obesity. FTO was biochemically shown to belong to the AlkB-like family DNA/RNA…”
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