Search Results - "Niu, Qing‐Tian"

Tissue‐Level Mechanisms Responsible for the Increase in Bone Formation and Bone Volume by Sclerostin Antibody by Ominsky, Michael S, Niu, Qing‐Tian, Li, Chaoyang, Li, Xiaodong, Ke, Hua Zhu

“…ABSTRACT Bone formation can be remodeling‐based (RBF) or modeling‐based (MBF), the former coupled to bone resorption and the latter occurring directly on…”
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Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis by Li, Xiaodong, Ominsky, Michael S, Warmington, Kelly S, Morony, Sean, Gong, Jianhua, Cao, Jin, Gao, Yongming, Shalhoub, Victoria, Tipton, Barbara, Haldankar, Raj, Chen, Qing, Winters, Aaron, Boone, Tom, Geng, Zhaopo, Niu, Qing‐Tian, Ke, Hua Zhu, Kostenuik, Paul J, Simonet, W Scott, Lacey, David L, Paszty, Chris

“…The development of bone‐rebuilding anabolic agents for potential use in the treatment of bone loss conditions, such as osteoporosis, has been a long‐standing…”
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Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength by Li, Xiaodong, Ominsky, Michael S, Niu, Qing‐Tian, Sun, Ning, Daugherty, Betsy, D'Agostin, Diane, Kurahara, Carole, Gao, Yongming, Cao, Jin, Gong, Jianhua, Asuncion, Frank, Barrero, Mauricio, Warmington, Kelly, Dwyer, Denise, Stolina, Marina, Morony, Sean, Sarosi, Ildiko, Kostenuik, Paul J, Lacey, David L, Simonet, W Scott, Ke, Hua Zhu, Paszty, Chris

“…Introduction: Sclerosteosis is a rare high bone mass genetic disorder in humans caused by inactivating mutations in SOST, the gene encoding sclerostin. Based…”
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Sustained Modeling‐Based Bone Formation During Adulthood in Cynomolgus Monkeys May Contribute to Continuous BMD Gains With Denosumab by Ominsky, Michael S, Libanati, Cesar, Niu, Qing‐Tian, Boyce, Rogely W, Kostenuik, Paul J, Wagman, Rachel B, Baron, Roland, Dempster, David W

“…ABSTRACT Denosumab (DMAb) administration to postmenopausal women with osteoporosis is associated with continued bone mineral density (BMD) increases and low…”
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Kinetic reconstruction reveals time-dependent effects of romosozumab on bone formation and osteoblast function in vertebral cancellous and cortical bone in cynomolgus monkeys by Boyce, Rogely Waite, Niu, Qing-Tian, Ominsky, Michael S

“…Abstract Romosozumab, a humanized monoclonal sclerostin antibody under development for the treatment of osteoporosis, has a unique mechanism of action on…”
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Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury by Roudier, Martine, Li, Xiaodong, Niu, Qing‐Tian, Pacheco, Efrain, Pretorius, James K., Graham, Kevin, Yoon, Bo‐Rin P., Gong, Jianhua, Warmington, Kelly, Ke, Hua Z., Black, Roy A., Hulme, Joanne, Babij, Philip

“…Objective Sclerostin plays a major role in regulating skeletal bone mass, but its effects in articular cartilage are not known. The purpose of this study was…”
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Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats by Li, Xiaodong, Warmington, Kelly S, Niu, Qing‐Tian, Asuncion, Franklin J, Barrero, Mauricio, Grisanti, Mario, Dwyer, Denise, Stouch, Brian, Thway, Theingi M, Stolina, Marina, Ominsky, Michael S, Kostenuik, Paul J, Simonet, William S, Paszty, Chris, Ke, Hua Zhu

“…The purpose of this study was to evaluate the effects of sclerostin inhibition by treatment with a sclerostin antibody (Scl‐AbII) on bone formation, bone mass,…”
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FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists by Li, Xiaodong, Stanislaus, Shanaka, Asuncion, Frank, Niu, Qing‐Tian, Chinookoswong, Narumol, Villasenor, Kelly, Wang, Jin, Wong, Philip, Boyce, Rogely, Dwyer, Denise, Han, Chun‐Ya, Chen, Michelle M, Liu, Benxian, Stolina, Marina, Ke, Hua Zhu, Ominsky, Michael S, Véniant, Murielle M, Xu, Jing

“…ABSTRACT Results of prior studies suggest that fibroblast growth factor 21 (FGF21) may be involved in bone turnover and in the actions of peroxisome…”
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Effects of various pine needle extracts on Chinese hamster ovary cell growth and monoclonal antibody quality by Zhang, Dingyue, Qiu, Jinshu, Niu, Qing-Tian, Liu, Tingting, Gu, Rulin, Zhang, Xiaoying, Luo, Shun

“…Chinese hamster ovary (CHO) cells are commonly used as "bio-machines" to pro-duce monoclonal antibodies (mAb) because of their ability to produce very complex…”
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Sclerostin Antibody Reverses Bone Loss by Increasing Bone Formation and Decreasing Bone Resorption in a Rat Model of Male Osteoporosis by Li, Xiaodong, Ominsky, Michael S, Villasenor, Kelly S, Niu, Qing-Tian, Asuncion, Frank J, Xia, Xuechun, Grisanti, Mario, Wronski, Thomas J, Simonet, W Scott, Ke, Hua Zhu

“…Sclerostin antibody (Scl-Ab) restored bone mass and strength in the ovariectomized rat model of postmenopausal osteoporosis. Increased bone mineral density…”
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Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats by Stolina, Marina, Dwyer, Denise, Niu, Qing-Tian, Villasenor, Kelly S, Kurimoto, Pam, Grisanti, Mario, Han, Chun-Ya, Liu, Min, Li, Xiaodong, Ominsky, Michael S, Ke, Hua Z, Kostenuik, Paul J

“…Abstract Sclerostin (Scl) is an osteocyte protein that decreases bone formation, and its inhibition by neutralizing antibodies (Scl-Ab) increases bone…”
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Journal of Bone and Mineral Research: Volume 30, Issue 5, May 2015, Frontmatter page ii by Ominsky, Michael S, Libanati, Cesar, Niu, Qing‐Tian, Boyce, Rogely W, Kostenuik, Paul J, Wagman, Rachel B, Baron, Roland, Dempster, David W

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Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis by Rasheed, Naslin, Wang, Xueying, Niu, Qing-Tian, Yeh, James, Li, Baojie

“…Atm is a Ser/Thr kinase involved in DNA damage response and is required for genome integrity and stem cell renewal. Here, we report an additional role for Atm…”
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One Year of Transgenic Overexpression of Osteoprotegerin in Rats Suppressed Bone Resorption and Increased Vertebral Bone Volume, Density, and Strength by Ominsky, Michael S, Stolina, Marina, Li, Xiaodong, Corbin, Timothy J, Asuncion, Franklin J, Barrero, Mauricio, Niu, Qing‐Tian, Dwyer, Denise, Adamu, Steven, Warmington, Kelly S, Grisanti, Mario, Tan, Hong L, Ke, Hua Z, Simonet, William S, Kostenuik, Paul J

“…RANKL is an essential mediator of bone resorption, and its activity is inhibited by osteoprotegerin (OPG). Transgenic (Tg) rats were engineered to continuously…”
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Progressive Increases in Bone Mass and Bone Strength in an Ovariectomized Rat Model of Osteoporosis After 26 Weeks of Treatment With a Sclerostin Antibody by Li, Xiaodong, Niu, Qing-Tian, Warmington, Kelly S, Asuncion, Franklin J, Dwyer, Denise, Grisanti, Mario, Han, Chun-Ya, Stolina, Marina, Eschenberg, Michael J, Kostenuik, Paul J, Simonet, William S, Ominsky, Michael S, Ke, Hua Zhu

“…The effects of up to 26 weeks of sclerostin antibody (Scl-Ab) treatment were investigated in ovariectomized (OVX) rats. Two months after surgery, 6-month-old…”
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Etelcalcetide (AMG 416), a peptide agonist of the calcium-sensing receptor, preserved cortical bone structure and bone strength in subtotal nephrectomized rats with established secondary hyperparathyroidism by Li, Xiaodong, Yu, Longchuan, Asuncion, Frank, Grisanti, Mario, Alexander, Shawn, Hensley, Kelly, Han, Chun-Ya, Niu, Qing-Tian, Dwyer, Denise, Villasenor, Kelly, Stolina, Marina, Dean, Charles, Ominsky, Michael S., Ke, Hua Zhu, Tomlinson, James E., Richards, William G.

“…Sustained elevation of parathyroid hormone (PTH) is catabolic to cortical bone, as evidenced by deterioration in bone structure (cortical porosity), and is a…”
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A possible role for melanocortin peptides in longitudinal growth by Yeh, James K, Evans, Jodi F, Niu, Qing-Tian, Aloia, John F

“…Clinical and in vitro data suggest a link between the elevation of the melanocortin peptide, ACTH, and longitudinal growth. Overproduction of ACTH in familial…”
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Increased Bone Formation and Bone Mass Induced by Sclerostin Antibody Is Not Affected by Pretreatment or Cotreatment with Alendronate in Osteopenic, Ovariectomized Rats by Li, Xiaodong, Ominsky, Michael S, Warmington, Kelly S, Niu, Qing-Tian, Asuncion, Franklin J, Barrero, Mauricio, Dwyer, Denise, Grisanti, Mario, Stolina, Marina, Kostenuik, Paul J, Simonet, William S, Paszty, Chris, Ke, Hua Zhu

“…Clinical studies have revealed a blunting of the bone anabolic effects of parathyroid hormone treatment in osteoporotic patients in the setting of pre- or…”
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Increased callus mass and enhanced strength during fracture healing in mice lacking the sclerostin gene by Li, Chaoyang, Ominsky, Michael S, Tan, Hong-Lin, Barrero, Mauricio, Niu, Qing-Tian, Asuncion, Franklin J, Lee, Edward, Liu, Min, Simonet, William S, Paszty, Chris, Ke, Hua Zhu

“…Abstract Humans with inherited sclerostin deficiency have high bone mass. Targeted deletion of the sclerostin gene in mice (SOST-KO) causes increases in bone…”
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Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin by Li, Xiaodong, Ominsky, Michael S, Stolina, Marina, Warmington, Kelly S, Geng, Zhaopo, Niu, Qing-Tian, Asuncion, Frank J, Tan, Hong-Lin, Grisanti, Mario, Dwyer, Denise, Adamu, Steven, Ke, Hua Zhu, Simonet, W. Scott, Kostenuik, Paul J

“…Abstract Orchiectomized (ORX) rats were used to examine the extent to which their increased bone resorption and decreased bone density might relate to…”
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