Search Results - "Niu, Huanmin"

Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab by Wang, Dawei, Xu, Qingqing, Yuan, Quan, Jia, Mengqi, Niu, Huanmin, Liu, Xiaofei, Zhang, Jinsan, Young, Charles Yf, Yuan, Huiqing

“…Anterior gradient 2 (AGR2), a protein belonging to the protein disulfide isomerase (PDI) family, is overexpressed in multiple cancers and promotes angiogenesis…”
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Downregulation of reticulocalbin‐1 differentially facilitates apoptosis and necroptosis in human prostate cancer cells by Liu, Xiaofei, Zhang, Nianzhao, Wang, Dawei, Zhu, Deyu, Yuan, Quan, Zhang, Xiulei, Qian, Lilin, Niu, Huanmin, Lu, Yi, Ren, Guijie, Tian, Keli, Yuan, Huiqing

“…Reticulocalbin 1 (RCN1), an endoplasmic reticulum (ER)‐resident Ca2+‐binding protein, is dysregulated in cancers, but its pathophysiological roles are largely…”
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The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer’s Disease or Vascular Diseases through Regulating Neuroplasticity by Ji, Shaozhen, Duan, Jiayu, Hou, Xiaobing, Zhou, Li, Qin, Weilan, Niu, Huanmin, Luo, Shuyun, Zhang, Yunling, Chan, Piu, Jin, Xianglan

“…Dementia affects millions of elderly worldwide causing remarkable costs to society, but effective treatment is still lacking. Acupuncture is one of the…”
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Comparison of the Mini‐Mental State Examination and Montreal Cognitive Assessment executive subtests in detecting post‐stroke cognitive impairment by Fu, Chen, Jin, Xianglan, Chen, Baoxin, Xue, Feiran, Niu, Huanmin, Guo, Rongjuan, Chen, Zhigang, Zheng, Hong, Wang, Le, Zhang, Yunling

“…Aim The Montreal Cognitive Assessment (MoCA) has been shown to be more sensitive in detecting executive dysfunction than the Mini‐Mental State Examination…”
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Diabetes and vascular mild cognitive impairment among Chinese ≥50 years: A cross‐sectional study with 2020 participants by Zhang, Yu, Liu, Wenna, Fu, Chen, Liu, Xuemei, Hou, Xiaobing, Niu, Huanmin, Li, Tao, Guo, Chunyan, Li, Aixun, Chen, Baoxin, Jin, Xianglan

“…Background With the decline of cognitive function in vascular cognitive impairment, the burden on the family and society will increase. Therefore, early…”
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Targeting of VPS18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance by Niu, Huanmin, Qian, Lilin, Luo, Yanhai, Wang, Fang, Zheng, Hongbo, Gao, Yanhui, Wang, Hanbo, Hu, Xuelei, Yuan, Huiqing, Lou, Hongxiang

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Investigation of dementia awareness among stroke patients in China: A cross-sectional study by Jing Zhou, Ying Wang, Jiayi Zhao, Baoxin Chen, Xuemei Liu, Chen Fu, Xiaobing Hou, Huanmin Niu, Yunling Zhang, Xianglan Jin

“…Objective: To provide guidelines for the prevention of post-stroke dementia, we investigated whether stroke patients were aware of post-stroke dementia and…”
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Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion by Niu, Huanmin, Qian, Lilin, Sun, Bin, Liu, Wenjian, Wang, Fang, Wang, Qian, Ji, Xiaotian, Luo, Yanhai, Nesa, Effat Un, Lou, Hongxiang, Yuan, Huiqing

“…It is critical to regulate the senescence-associated secretory phenotype (SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency…”
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Overexpression of VPS16 correlates with tumor progression and chemoresistance in colorectal cancer by Zhang, Baoqing, Ma, Yuanyuan, Niu, Huanmin, Liu, Zhenji

“…Vacuolar protein sorting-associated protein 16 homolog (VPS16) is a central member of the VPS core complex (VPS–C) and is reported to function as a tether…”
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lncARSR sponges miR‐34a‐5p to promote colorectal cancer invasion and metastasis via hexokinase‐1‐mediated glycolysis by Li, Shuai, Zhu, Kongxi, Liu, Lan, Gu, Jiaoyang, Niu, Huanmin, Guo, Jianqiang

“…Aerobic glycolysis metabolic reprogramming is one of the most important hallmarks of malignant tumors. Increasing evidence indicates that long non‐coding RNAs…”
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ent-Kaurane Diterpenoids from Chinese Liverworts and Their Antitumor Activities through Michael Addition As Detected in Situ by a Fluorescence Probe by Lin, Zhaomin, Guo, Yanxia, Gao, Yanhui, Wang, Shuqi, Wang, Xiaoning, Xie, Zhiyu, Niu, Huanmin, Chang, Wenqiang, Liu, Lei, Yuan, Huiqing, Lou, Hongxiang

“…It is generally accepted that the origin of the cytotoxicity of ent-kaurane diterpenoids is due to the formation of reactive oxygen species (ROS) and that the…”
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STAT3 contributes to lysosomal-mediated cell death in a novel derivative of riccardin D-treated breast cancer cells in association with TFEB by Li, Lin, Sun, Bin, Gao, Yun, Niu, Huanmin, Yuan, Huiqing, Lou, Hongxiang

“…[Display omitted] RDD648, a novel derivative of a natural molecule riccardin D, exhibited potent anticancer activity by targeting lysosomes in vitro and in…”
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Riccardin D-N induces lysosomal membrane permeabilization by inhibiting acid sphingomyelinase and interfering with sphingomyelin metabolism in vivo by Li, Lin, Niu, Huanmin, Sun, Bin, Xiao, Yanan, Li, Wei, Yuan, Huiqing, Lou, Hongxiang

“…Lysosomes are important targets for anticancer drug discovery. Our previous study showed that Riccardin D-N (RD-N), a natural macrocylic bisbibenzyl derivative…”
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Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity by Li, Siwen, Niu, Huanmin, Qiao, Yanan, Zhu, Rongxiu, Sun, Yong, Ren, Zhaojie, Yuan, Huiqing, Gao, Yun, Li, Yi, Chen, Wang, Zhou, Jinchuan, Lou, Hongxiang

“…[Display omitted] Five new terpenoids (1–5) including two dollabellane-type, one ent-kaurane-type diterpenoids and two sesquiterpenoids were isolated from the…”
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Hyper‐acetylation contributes to the sensitivity of chemo‐resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A by Xu, Qingqing, Liu, Xiaofei, Zhu, Shiqin, Hu, Xuelei, Niu, Huanmin, Zhang, Xiulei, Zhu, Deyu, Nesa, Effat Un, Tian, Keli, Yuan, Huiqing

“…Therapeutic agents are urgently needed for treating metastatic castration‐refractory prostate cancer (mCRPC) that is unresponsive to androgen deprivation and…”
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Targeting the lysosome by an aminomethylated Riccardin D triggers DNA damage through cathepsin B‐mediated degradation of BRCA1 by Wang, Yanyan, Niu, Huanmin, Hu, Zhongyi, Zhu, Mengyuan, Wang, Lining, Han, Lili, Qian, Lilin, Tian, Keli, Yuan, Huiqing, Lou, Hongxiang

“…RD‐N, an aminomethylated derivative of riccardin D, is a lysosomotropic agent that can trigger lysosomal membrane permeabilization followed by cathepsin B…”
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Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation by Wang, Yunqiu, Jia, Mengqi, Liang, Chuanjie, Sheng, Nan, Wang, Xiaodan, Wang, Fang, Luo, Yanhai, Jiang, Jin, Cai, Liangyu, Niu, Huanmin, Zhu, Deyu, Nesa, Effat Un, Young, Charles Yf, Yuan, Huiqing

“…Anterior gradient 2 (AGR2), a protein disulfide isomerase (PDI), is a well-established oncogene. Here, we found that mice had a decreased fat mass and hepatic…”
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Targeting VPS18 hampers retromer trafficking of PD-L1 and augments immunotherapy by Dong, Ting, Niu, Huanmin, Chu, Zhaojun, Zhou, Chengjun, Gao, Yinghui, Jia, Mengqi, Sun, Bin, Zheng, Xiaoxue, Zhang, Wenru, Zhang, Jiaozhen, Luo, Yanhai, Sun, Yong, Wang, Chan, Lu, Qiqi, Liu, Changhong, Shao, Guangfeng, Lou, Hongxiang, Yuan, Huiqing

“…Immune checkpoint inhibitors targeting programmed cell death 1 (PD-1) or programmed cell death-ligand 1 (PD-L1) have achieved impressive antitumor clinical…”
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Metabolic Syndrome and Cognitive Performance Among Chinese ≥50 Years: A Cross-Sectional Study with 3988 Participants by Chen, Baoxin, Jin, Xianglan, Guo, Rongjuan, Chen, Zhigang, Hou, Xiaobing, Gao, Fang, Zhang, Yanxia, Zheng, Shuo, Fu, Chen, Xue, Feiran, Niu, Huanmin, Zhang, Yunling

“…To date, the relationship between metabolic syndrome (MetS) and cognitive performance has not been well defined. This study aimed to explore the relationship…”
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Quantitative study evaluating perception of general public towards role of pharmacist in health care system of Pakistan by Jin, Xianglan, Azhar, Saira, Murtaza, Ghulam, Xue, Feiran, Mumtaz, Amara, Niu, Huanmin, Taha, Asia, Zhang, Yunling

“…To investigate general public perception towards the role of pharmacist in developing countries' healthcare system was the main aim of this study, which would…”
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