Search Results - "Nitu, Sadia S."
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Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes
Published in Redox biology (01-09-2020)“…Mitochondria are highly dynamic organelles that constantly undergo fission and fusion events to adapt to changes in the cellular environment. Aberrant…”
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Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels
Published in Frontiers in physiology (27-03-2023)“…Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has…”
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Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G-αB-Crystallin-Induced Desmin-Related Cardiomyopathy
Published in Journal of the American Heart Association (01-12-2020)“…Background The mutated α-B-Crystallin (CryAB ) mouse model of desmin-related myopathy (DRM) shows an age-dependent onset of pathologic cardiac remodeling and…”
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Abstract P2039: The Absence Of Sigmar1 Causes Increased Protein Aggregation And Aggravated Cardiac Dysfunction In R120g- αb-Crystallin Mouse
Published in Circulation research (05-08-2022)“…BackgroundαB-Crystallin (CryAB) is a molecular chaperone responsible for protecting intermediate filaments by maintaining the structural integrity of the…”
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Abstract P3040: Mitochondrial Membrane Protein Sigmar1 Regulates Mitochondrial Ultrastructure And Respiratory Functions In The Heart
Published in Circulation research (05-08-2022)“…BackgroundSigma-1 receptor (Sigmar1) is multifunctional, ubiquitously expressed chaperone protein in mammalian cell systems. Earlier biochemical and…”
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Sigmar1's Subcellular Localization and Function in the Heart
Published in The FASEB journal (01-05-2021)“…Background Sigma‐1 receptor (Sigmar1) is a widely expressed molecular chaperone protein in mammalian cell systems. Accumulating research demonstrated the…”
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