Search Results - "Nitta, Aiko"

Bioceramics Enhance the Anti-Tumor Activity of Immune Cells in Adoptive Immunotherapy by Nose, Masato, Nitta, Aiko, Zheng, Yundi, Kizukuri, Rihoko, Nagao, Yuki, Nagai, Shigenori, Aizawa, Mamoru

“…Recent research has focused on immunotherapy with no side effects as an innovative medical treatment for cancer. However, typical drugs for immunotherapy are…”
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Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2 by Fuchi, Nobuhiro, Iura, Yosuke, Kaneko, Hiroaki, Nitta, Aiko, Suyama, Kazuharu, Ueda, Hiroshi, Yamaguchi, Shinichi, Nishimura, Kazumi, Fujii, Shigeo, Sekiya, Yumiko, Yamada, Masateru, Takahashi, Toshiya

“…We report the discovery and structure–activity relationship of 2,6-disubstituted pyrazines, which are potent and selective CK2 inhibitors. Lead compound 1 was…”
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(3 R)-3-Amino-4-(2,4,5-trifluorophenyl)- N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes by Nitta, Aiko, Fujii, Hideaki, Sakami, Satoshi, Nishimura, Yutaka, Ohyama, Tomofumi, Satoh, Mikiya, Nakaki, Junko, Satoh, Shiho, Inada, Chifumi, Kozono, Hideki, Kumagai, Hiroki, Shimamura, Masahiro, Fukazawa, Tominaga, Kawai, Hideki

“…Novel series of 3-amino- N-(4-aryl-1,1-dioxothian-4-yl)butanamides and 3-amino- N-(4-aryltetrahydropyran-4-yl)butanamides were synthesized and evaluated as…”
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Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors by Nitta, Aiko, Fujii, Hideaki, Sakami, Satoshi, Satoh, Mikiya, Nakaki, Junko, Satoh, Shiho, Kumagai, Hiroki, Kawai, Hideki

“…A series of novel 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides were investigated as dipeptidyl peptidase IV (DPP-4) inhibitors. Introduction of a…”
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HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models by Okazaki, Seiji, Takahashi, Takehiro, Iwamura, Tomokatsu, Nakaki, Junko, Sekiya, Yumiko, Yagi, Mai, Kumagai, Hiroki, Sato, Mikiya, Sakami, Satoshi, Nitta, Aiko, Kawai, Koji, Kainoh, Mie

“…11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is considered a potential therapeutic target in the treatment of type 2 diabetes mellitus. In this study, we…”
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Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1 by Udagawa, Shuji, Sakami, Satoshi, Takemura, Takahiro, Sato, Mikiya, Arai, Takahiro, Nitta, Aiko, Aoki, Takumi, Kawai, Koji, Iwamura, Tomokatsu, Okazaki, Seiji, Takahashi, Takehiro, Kaino, Mie

“…A series of novel 5-trans-hydroxyadamantan-2-yl-5,6,7,8-tetrahydropyrazolo[4,3-c]azepin-4(1H)-ones that inhibit 11beta-hydroxysteroid dehydrogenase type 1 are…”
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Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists by Nitta, Aiko, Iura, Yosuke, Inoue, Hideki, Sato, Ippei, Morihira, Koichiro, Kubota, Hirokazu, Morokata, Tatsuaki, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Imaoka, Takayuki, Takahashi, Toshiya

“…Optimization starting with our lead compound 1 (IC50=4.9nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward…”
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Discovery and structure–activity relationships of urea derivatives as potent and novel CCR3 antagonists by Nitta, Aiko, Iura, Yosuke, Tomioka, Hiroki, Sato, Ippei, Morihira, Koichiro, Kubota, Hirokazu, Morokata, Tatsuaki, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Imaoka, Takayuki, Takahashi, Toshiya

“…The synthesis and structure–activity relationships of ureas as CCR3 antagonists are described. Optimization starting with lead compound 2 (IC50=190nM) derived…”
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Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…The 6-fluoro-2-naphthylmethyl derivatives were prepared, and their inhibitory activities against CCR3 and CYP2D6 were evaluated. In our previous study on…”
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Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Ohno, Kazuki, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…Acrylamide derivatives were prepared, and their inhibitory activity against CCR3 and in vitro metabolic stability against human liver microsomes (HLMs) were…”
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Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Hamada, Noritaka, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…The 6-fluoro-2-naphthylmethyl derivatives were prepared, and their inhibitory activities against CCR3 were evaluated. A novel class of potent CCR3 receptor…”
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Corrigendum to “Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists” [Bioorg. Med. Chem. 16 (2008) 144–156] by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Hamada, Noritaka, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

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(3R)-3-Amino-4-( 2,4,5 -trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-ylbutanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes by NITTA, Aiko, FUJII, Hideaki, KUMAGAI, Hiroki, SHIMAMURA, Masahiro, FUKAZAWA, Tominaga, KAWAI, Hideki, SAKAMI, Satoshi, NISHIMURA, Yutaka, OHYAMA, Tomofumi, SATOH, Mikiya, NAKAKI, Junko, SATOH, Shiho, INADA, Chifumi, KOZONO, Hideki

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Synthesis and structure-activity relationships of N-{1-[(6-fluoro2-naphthyl)methyl]piperidin-4-yl} benzamide derivatives as novel CCR3 antagonists : Nucleic Acid Modification for Fluoescence-Based Technologies by SATO, Ippei, MORIHIRA, Koichiro, TAKAHASHI, Toshiya, TAKEUCHI, Makoto, OHTA, Mitsuaki, TSUKAMOTO, Shin-Ichi, INAMI, Hiroshi, KUBOTA, Hirokazu, MOROKATA, Tatsuaki, SUZUKI, Keiko, HAMADA, Noritaka, IURA, Yosuke, NITTA, Aiko, IMAOKA, Takayuki

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