Search Results - "Nitschke, Y"

Severe early‐onset manifestations of pseudoxanthoma elasticum resulting from the cumulative effects of several deleterious mutations in ENPP1, ABCC6 and HBB: transient improvement in ectopic calcification with sodium thiosulfate by Omarjee, L., Nitschke, Y., Verschuere, S., Bourrat, E., Vignon, M.‐D., Navasiolava, N., Leftheriotis, G., Kauffenstein, G., Rutsch, F., Vanakker, O.M., Martin, L.

“…Summary Pseudoxanthoma elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues…”
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Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice by Bertrand, J, Nitschke, Y, Fuerst, M, Hermann, S, Schäfers, M, Sherwood, J, Nalesso, G, Ruether, W, Rutsch, F, Dell'Accio, F, Pap, T

“…To analyse the function of nucleotide pyrophosphatase phosphodiesterase (NPP1), a member of the pyrophosphate pathway, in osteoarthritis (OA). mRNA expression…”
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BCP crystals induce hypertrophic differentiation of chondrocytes by activating canonical wnt signaling by Kräft, T, Godmann, L, Hubert, J, Nitschke, Y, Hawellek, T, Liote, F, Pap, T, Bertrand, J

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200 CYTOKINES DOWNREGULATE NPPl AND THEREFORE INDUCE CARTILAGE MINERALIZATION IN OA by Bertrand, J, Nitschke, Y, Fuerst, M, Ruether, W, Rutsch, F, Nalesso, G, Dell'Accio, F, Pap, T

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Calcification of articular cartilage in human osteoarthritis by Fuerst, M., Bertrand, J., Lammers, L., Dreier, R., Echtermeyer, F., Nitschke, Y., Rutsch, F., Schäfer, F. K. W., Niggemeyer, O., Steinhagen, J., Lohmann, C. H., Pap, T., Rüther, W.

“…Objective Hypertrophic chondrocyte differentiation is a key step in endochondral ossification that produces basic calcium phosphates (BCPs). Although…”
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Fetal hydrops, hyperechogenic arteries and pathological doppler findings at 29 weeks: prenatal presentation of generalized arterial calcification of infancy - a novel mutation in ENPP1 by Reitter, A, Fischer, D, Buxmann, H, Nitschke, Y, Rutsch, F, Mottok, A, Hansmann, M L, Harms, E, Louwen, F, Schlosser, R

“…Prenatal diagnosis of generalized arterial calcification of infancy (GACI) (OMIM #208000) is difficult and rare. There are various known gene mutations in…”
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Inherited Arterial Calcification Syndromes: Etiologies and Treatment Concepts by Nitschke, Yvonne, Rutsch, Frank

“…Purpose of Review We give an update on the etiology and potential treatment options of rare inherited monogenic disorders associated with arterial…”
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INZ-701, a recombinant ENPP1-Fc protein, effectively treats and prevents neointimal proliferation in WT and ENPP1 Deficient mice by Rutsch, F, O'brien, K, Nitschke, Y, Sullivan, C, Howe, J, Lynch, A, Schrier, D, Thompson, D, Sabbagh, Y

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BCP crystals drive chondrocyte hypertrophic differentiation via binding WNT ligands and activation of canonical WNT signaling by Bertrand, J., Kräft, T., Nitschke, Y., Rutsch, F., Liote, F., Pap, T.

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Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet by Bäck, Magnus, Aranyi, Tamas, Cancela, M Leonor, Carracedo, Miguel, Conceição, Natércia, Leftheriotis, Georges, Macrae, Vicky, Martin, Ludovic, Nitschke, Yvonne, Pasch, Andreas, Quaglino, Daniela, Rutsch, Frank, Shanahan, Catherine, Sorribas, Victor, Szeri, Flora, Valdivielso, Pedro, Vanakker, Olivier, Kempf, Hervé

“…The physicochemical deposition of calcium-phosphate in the arterial wall is prevented by calcification inhibitors. Studies in cohorts of patients with rare…”
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Singleton-Merten Syndrome: a rare autoimmune disorder caused by a specific IFIH1 mutation by Buers, I, Nitschke, Y, Hennekam, RC, MacDougall, M, Lu, C, Mamaeva, O, Rice, GI, Erlandsen, H, Kehl, HG, Thiele, H, Nürnberg, P, Höhne, W, Crow, YJ, Feigenbaum, A, Rutsch, F

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MS152 DEFICIENCY OF NPP1 ATTENUATES ATHEROSCLEROTIC LESION PROGRESSION IN apoE KNOCKOUT MICE by Nitschke, Y., Weissen-Plenz, G., Terkeltaub, R., Rutsch, F.

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Abstract: P183 ARTERIAL CALCIFICATION AND INTIMAL PROLIFERATION: TWO INDEPENDENT PROCESSES IN ENPP1 DEFICIENCY by Nitschke, Y, Hansen, U, Völker, W, Bruckner, P, Rutsch, F

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Mo-P6:447 Mechanisms of arterial calcification: Genotype and phenotype of NPP1 deficiency in mice and man by Rutsch, F., Nitschke, Y., Hansen, U., Völker, W., Bruckner, P., Ruf, N., Schnabel, D., Terkeltaub, R., Nürberg, P., Weissen-Plenz, G.

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