Search Results - "Nitsch, R."

Neuronal Mechanisms Recording the Stream of Consciousness-A Reappraisal of Wilder Penfield's (1891-1976) Concept of Experiential Phenomena Elicited by Electrical Stimulation of the Human Cortex by Nitsch, R, Stahnisch, F W

“…Abstract Research on memory has been a major focus in the neurosciences over the past decades. An important advance was achieved by Wilder Penfield at the…”
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T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis by Ferretti, M.T, Merlini, M, Späni, C, Gericke, C, Schweizer, N, Enzmann, G, Engelhardt, B, Kulic, L, Suter, T, Nitsch, R.M

“…Highlights • APP transgenic mice reproduce the Alzheimer’s like occurrence of brain T-cells. • Infiltrating T-cells do not specifically associate with amyloid…”
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Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment by van Bergen, J. M. G., Li, X., Hua, J., Schreiner, S. J., Steininger, S. C., Quevenco, F. C., Wyss, M., Gietl, A. F., Treyer, V., Leh, S. E., Buck, F., Nitsch, R. M., Pruessmann, K. P., van Zijl, P. C. M., Hock, C., Unschuld, P. G.

“…Quantitative Susceptibility Mapping (QSM) MRI at 7 Tesla and 11-Carbon Pittsburgh-Compound-B PET were used for investigating the relationship between brain…”
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Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss by Birnbaum, J H, Bali, J, Rajendran, L, Nitsch, R M, Tackenberg, C

“…Synaptic loss is one of the major features of Alzheimer’s disease (AD) and correlates with the degree of dementia. N -methyl- d -aspartate receptors (NMDARs)…”
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Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and β-amyloid as an indicator of cognitive performance at high age by van Bergen, J.M.G., Li, X., Quevenco, F.C., Gietl, A.F., Treyer, V., Meyer, R., Buck, A., Kaufmann, P.A., Nitsch, R.M., van Zijl, P.C.M., Hock, C., Unschuld, P.G.

“…The accumulation of β-amyloid plaques is a hallmark of Alzheimer's disease (AD), and recently published data suggest that increased brain iron burden may…”
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Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils by Götz, J., Chen, F., van Dorpe, J., Nitsch, R. M.

“…β-Amyloid plaques and neurofibrillary tangles (NFTs) are the defining neuropathological hallmarks of Alzheimer's disease, but their pathophysiological relation…”
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In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model by Carreras, Alba, Pane, Luna Simona, Nitsch, Roberto, Madeyski-Bengtson, Katja, Porritt, Michelle, Akcakaya, Pinar, Taheri-Ghahfarokhi, Amir, Ericson, Elke, Bjursell, Mikael, Perez-Alcazar, Marta, Seeliger, Frank, Althage, Magnus, Knöll, Ralph, Hicks, Ryan, Mayr, Lorenz M, Perkins, Rosie, Lindén, Daniel, Borén, Jan, Bohlooly-Y, Mohammad, Maresca, Marcello

“…Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein…”
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NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss by Tackenberg, C, Grinschgl, S, Trutzel, A, Santuccione, A C, Frey, M C, Konietzko, U, Grimm, J, Brandt, R, Nitsch, R M

“…Aggregates of amyloid-beta (A β ) and tau are hallmarks of Alzheimer’s disease (AD) leading to neurodegeneration and synaptic loss. While increasing evidence…”
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Genetic ablation of the p66 Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease by Derungs, R, Camici, G G, Spescha, R D, Welt, T, Tackenberg, C, Späni, C, Wirth, F, Grimm, A, Eckert, A, Nitsch, R M, Kulic, L

“…The mammalian ShcA adaptor protein p66 is a key regulator of mitochondrial reactive oxygen species (ROS) production and has previously been shown to mediate…”
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BRAIN-REACTIVE β-AMYLOID ANTIBODIES IN PRIMARY CNS ANGIITIS WITH CEREBRAL AMYLOID ANGIOPATHY by HERMANN, D. M, KEYVANI, K, VAN DE NES, J, WEIMAR, C, WILTFANG, J, NITSCH, R. M, SZODORAI, A

“…Primary CNS angiitis (PCNSA) is a focal or multifocal vasculitis with predilection for small arteries that is restricted to the brain or spinal cord…”
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Formation of neurofibrillary tangles in P301L tau transgenic mice induced by A beta 42 fibrils by Goetz, J, Chen, F, van Dorpe, J, Nitsch, R M

“…beta -Amyloid plaques and neurofibrillary tangles (NFTs) are the defining neuropathological hallmarks of Alzheimer's disease, but their pathophysiological…”
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Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice by Santuccione, A C, Merlini, M, Shetty, A, Tackenberg, C, Bali, J, Ferretti, M T, McAfoose, J, Kulic, L, Bernreuther, C, Welt, T, Grimm, J, Glatzel, M, Rajendran, L, Hock, C, Nitsch, R M

“…Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses…”
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Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma by Savaskan, N E, Rocha, L, Kotter, M R, Baer, A, Lubec, G, van Meeteren, L A, Kishi, Y, Aoki, J, Moolenaar, W H, Nitsch, R, Bräuer, A U

“…Autotaxin is a secreted cell motility-stimulating exo-phosphodiesterase with lysophospholipase D activity that generates bioactive lysophosphatidic acid…”
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GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults by Quevenco, F C, Schreiner, S J, Preti, M G, van Bergen, J M G, Kirchner, T, Wyss, M, Steininger, S C, Gietl, A, Leh, S E, Buck, A, Pruessmann, K P, Hock, C, Nitsch, R M, Henning, A, Van De Ville, D, Unschuld, P G

“…Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive…”
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Disseminated Peritoneal Leiomyomatosis after Morcellation by Davies, P, Nitsch, R, Reid, R, MacDonald, P.H

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Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice by Pennanen, L., Wolfer, D. P., Nitsch, R. M., Götz, J.

“…The neuropathological hallmark shared between Alzheimer's disease (AD) and familial frontotemporal dementia (FTDP‐17) are neurofibrillary tangles (NFT) which…”
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The Human DIMINUTO/DWARF1 Homolog Seladin-1 Confers Resistance to Alzheimer's Disease-Associated Neurodegeneration and Oxidative Stress by Greeve, Isabell, Hermans-Borgmeyer, Irm, Brellinger, Claire, Kasper, Dagmar, Gomez-Isla, Teresa, Behl, Christian, Levkau, Bodo, Nitsch, Roger M

“…In Alzheimer's disease (AD) brains, selected populations of neurons degenerate heavily, whereas others are frequently spared from degeneration. To address the…”
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Randomized, placebo-controlled, phase 1b study of anti-beta-amyloid antibody aducanumab (biib037) in prodromal ad/mild ad dementia: Interim results by patient subgroup by Sevigny, J, Chiao, P, Williams, L, Chen, T, Ling, Y, O’Gorman, J, Hock, C, Nitsch, R, Sandrock, A

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Deviance-related electrophysiological activity in mice: is there mismatch negativity in mice? by Umbricht, D., Vyssotki, D., Latanov, A., Nitsch, R., Lipp, H.-P.

“…Mismatch negativity (MMN) is an auditory event-related potential (ERP) that provides an index of auditory sensory memory and has become an important tool to…”
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High Prevalence of Pathogenic Mutations in Patients with Early-Onset Dementia Detected by Sequence Analyses of Four Different Genes by Finckh, Ulrich, Müller-Thomsen, Tomas, Mann, Ulrike, Eggers, Christian, Marksteiner, Josef, Meins, Wolfgang, Binetti, Giuliano, Alberici, Antonella, Hock, Christoph, Nitsch, Roger M., Gal, Andreas

“…Clinical differential diagnosis of early-onset dementia (EOD) includes familial Alzheimer disease (FAD) and hereditary prion disease. In both disease entities,…”
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