Search Results - "Nitiss, Karin C"

Genome Instability Induced by Topoisomerase Misfunction by Nitiss, Karin C, Bandak, Afif, Berger, James M, Nitiss, John L

“…Topoisomerases alter DNA topology by making transient DNA strand breaks (DSBs) in DNA. The DNA cleavage reaction mechanism includes the formation of a…”
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Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes by Katyal, Sachin, Lee, Youngsoo, Nitiss, Karin C, Downing, Susanna M, Li, Yang, Shimada, Mikio, Zhao, Jingfeng, Russell, Helen R, Petrini, John H J, Nitiss, John L, McKinnon, Peter J

“…In this study, the authors show that topoisomerase-1–DNA cleavage complex (Top1cc) accumulation may be involved in the onset of ataxia telangiectasia and…”
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Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2) by Gao, Rui, Schellenberg, Matthew J., Huang, Shar-yin N., Abdelmalak, Monica, Marchand, Christophe, Nitiss, Karin C., Nitiss, John L., Williams, R. Scott, Pommier, Yves

“…Eukaryotic type II topoisomerases (Top2α and Top2β) are homodimeric enzymes; they are essential for altering DNA topology by the formation of normally…”
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TDP1 is required for efficient non-homologous end joining in human cells by Li, Jing, Summerlin, Matthew, Nitiss, Karin C., Nitiss, John L., Hanakahi, Leslyn A.

“…•Loss of TDP1 significantly reduces end joining of restriction enzyme induced DSBs in human cells.•TDP1-deficeint human cells also show reduced end-joining…”
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Requirements for MRN endonuclease processing of topoisomerase II-mediated DNA damage in mammalian cells by Sun, Yilun, Soans, Eroica, Mishina, Margarita, Petricci, Elena, Pommier, Yves, Nitiss, Karin C., Nitiss, John L.

“…During a normal topoisomerase II (TOP2) reaction, the enzyme forms a covalent enzyme DNA intermediate consisting of a 5′ phosphotyrosyl linkage between the…”
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TDP1 promotes assembly of non-homologous end joining protein complexes on DNA by Heo, Jinho, Li, Jing, Summerlin, Matthew, Hays, Annette, Katyal, Sachin, McKinnon, Peter J., Nitiss, Karin C., Nitiss, John L., Hanakahi, Leslyn A.

“…•End-processing factor TDP1 interacts with the NHEJ factor XLF to form a TDP1:XLF:DNA complex.•XLF stimulates TDP1 enzymatic activity on dsDNA.•TDP1 also…”
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Tyrosyl-DNA Phosphodiesterase (Tdp1) Participates in the Repair of Top2-Mediated DNA Damage by Nitiss, Karin C., Malik, Mobeen, He, Xiaoping, White, Stephen W., Nitiss, John L.

“…Agents targeting topoisomerases are active against a wide range of human tumors. Stabilization of covalent complexes, converting topoisomerases into…”
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Tdp2: a means to fixing the ends by Nitiss, John L, Nitiss, Karin C

“…  A key finding from the original identification of Tdp2 was that the protein was more active in processing 5' phosphotyrosyl-linked oligonucleotides, and that…”
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Yeast Tdp1 regulates the fidelity of nonhomologous end joining by Bahmed, Karim, Nitiss, Karin C, Nitiss, John L

“…Tyrosyl-DNA-phosphodiesterase 1 (Tdp1) can disjoin peptides covalently bound to DNA. We assessed the role of Tdp1 in nonhomologous end joining (NHEJ) and found…”
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Roles of nonhomologous end-joining pathways in surviving topoisomerase II–mediated DNA damage by Malik, Mobeen, Nitiss, Karin C., Enriquez-Rios, Vanessa, Nitiss, John L.

“…Topoisomerase II is a target for clinically active anticancer drugs. Drugs targeting these enzymes act by preventing the religation of enzyme-DNA covalent…”
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Enhancing drug accumulation in Saccharomyces cerevisiae by repression of pleiotropic drug resistance genes with chimeric transcription repressors by Stepanov, Alexander, Nitiss, Karin C, Neale, Geoffrey, Nitiss, John L

“…Yeast is a powerful model system for studying the action of small-molecule therapeutics. An important limitation has been low efficacy of many small molecules…”
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Modeling allosteric mechanisms of eukaryotic type II topoisomerases by Evoli, Stefania, Kariyawasam, Nilusha L, Nitiss, Karin C, Nitiss, John L, Wereszczynski, Jeff

“…Type II topoisomerases (TopoIIs) are ubiquitous enzymes that are involved in crucial nuclear processes such as genome organization, chromosome segregation, and…”
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Twisting and ironing: doxorubicin cardiotoxicity by mitochondrial DNA damage by Nitiss, Karin C, Nitiss, John L

“…Anthracyclines are active clinical agents that have multiple mechanisms of cytotoxicity. Cardiotoxicity by anthracyclines limits the therapeutic potential of…”
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Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers by Boot, Arnoud, Liu, Mo, Stantial, Nicole, Shah, Viraj, Yu, Willie, Nitiss, Karin C, Nitiss, John L, Jinks-Robertson, Sue, Rozen, Steven G

“…Topoisomerases nick and reseal DNA to relieve torsional stress associated with transcription and replication and to resolve structures such as knots and…”
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UnTTrapping the ends： A new player in overcoming protein linked DNA damage by Bahmed, Karim, Nitiss, Karin C, Nitiss, John L

“…DNA topoisomerases carry out their reactions by generating transient covalent phosphotyrosine intermediates with DNA [ 1 ]. This reaction mechanism allows…”
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Using energy to go downhill—a genoprotective role for ATPase activity in DNA topoisomerase II by Bandak, Afif F, Blower, Tim R, Nitiss, Karin C, Shah, Viraj, Nitiss, John L, Berger, James M

“…Abstract Type II topoisomerases effect topological changes in DNA by cutting a single duplex, passing a second duplex through the break, and resealing the…”
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A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation by Sun, Yilun, Miller Jenkins, Lisa M, Su, Yijun P, Nitiss, Karin C, Nitiss, John L, Pommier, Yves

“…Topoisomerases form transient covalent DNA cleavage complexes to perform their reactions. Topoisomerase I cleavage complexes (TOP1ccs) are trapped by…”
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Naturally mutagenic sequence diversity in a human type II topoisomerase by Bandak, Afif F, Blower, Tim R, Nitiss, Karin C, Gupta, Raveena, Lau, Albert Y, Guha, Ria, Nitiss, John L, Berger, James M

“…Type II topoisomerases transiently cleave duplex DNA as part of a strand passage mechanism that helps control chromosomal organization and superstructure…”
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Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast by Stantial, Nicole, Rogojina, Anna, Gilbertson, Matthew, Sun, Yilun, Miles, Hannah, Shaltz, Samantha, Berger, James, Nitiss, Karin C., Jinks-Robertson, Sue, Nitiss, John L.

“…Topoisomerase II (Top2) is an essential enzyme that resolves catenanes between sister chromatids as well as supercoils associated with the over- or…”
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Detection of Topoisomerase Covalent Complexes in Eukaryotic Cells by Anand, Jay, Sun, Yilun, Zhao, Yang, Nitiss, Karin C, Nitiss, John L

“…DNA topoisomerases carry out topological transformations of DNA by introducing transient DNA breaks. The covalent intermediate of topoisomerase reactions…”
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