Search Results - "Nitiss, John L."

Targeting DNA topoisomerase II in cancer chemotherapy by Nitiss, John L

“…The ability to interfere with topoisomerase II (TOP2) and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. Can recent…”
Get full text

DNA topoisomerase II and its growing repertoire of biological functions by Nitiss, John L

“…The importance of targeting toposimerase II (TOP2) for the treatment of cancer is not a new concept; however, understanding of the biological functions of this…”
Get full text

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability by Pommier, Yves, Sun, Yilun, Huang, Shar-yin N., Nitiss, John L.

“…Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, thereby mediating chromatin dynamics and stability, transcription, replication and DNA…”
Get full text

Using energy to go downhill—a genoprotective role for ATPase activity in DNA topoisomerase II by Bandak, Afif F, Blower, Tim R, Nitiss, Karin C, Shah, Viraj, Nitiss, John L, Berger, James M

“…Abstract Type II topoisomerases effect topological changes in DNA by cutting a single duplex, passing a second duplex through the break, and resealing the…”
Get full text

Genome Instability Induced by Topoisomerase Misfunction by Nitiss, Karin C, Bandak, Afif, Berger, James M, Nitiss, John L

“…Topoisomerases alter DNA topology by making transient DNA strand breaks (DSBs) in DNA. The DNA cleavage reaction mechanism includes the formation of a…”
Get full text

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes by Katyal, Sachin, Lee, Youngsoo, Nitiss, Karin C, Downing, Susanna M, Li, Yang, Shimada, Mikio, Zhao, Jingfeng, Russell, Helen R, Petrini, John H J, Nitiss, John L, McKinnon, Peter J

“…In this study, the authors show that topoisomerase-1–DNA cleavage complex (Top1cc) accumulation may be involved in the onset of ataxia telangiectasia and…”
Get full text

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2) by Gao, Rui, Schellenberg, Matthew J., Huang, Shar-yin N., Abdelmalak, Monica, Marchand, Christophe, Nitiss, Karin C., Nitiss, John L., Williams, R. Scott, Pommier, Yves

“…Eukaryotic type II topoisomerases (Top2α and Top2β) are homodimeric enzymes; they are essential for altering DNA topology by the formation of normally…”
Get full text

TDP1 is required for efficient non-homologous end joining in human cells by Li, Jing, Summerlin, Matthew, Nitiss, Karin C., Nitiss, John L., Hanakahi, Leslyn A.

“…•Loss of TDP1 significantly reduces end joining of restriction enzyme induced DSBs in human cells.•TDP1-deficeint human cells also show reduced end-joining…”
Get full text

Editorial: The repair of DNA-protein crosslinks by Sun, Yilun, Nitiss, John L, Pommier, Yves

Get full text

SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases by Sun, Yilun, Nitiss, John L, Pommier, Yves

“…Topoisomerases play crucial roles in DNA metabolism that include replication, transcription, recombination, and chromatin structure by manipulating DNA…”
Get full text

Requirements for MRN endonuclease processing of topoisomerase II-mediated DNA damage in mammalian cells by Sun, Yilun, Soans, Eroica, Mishina, Margarita, Petricci, Elena, Pommier, Yves, Nitiss, Karin C., Nitiss, John L.

“…During a normal topoisomerase II (TOP2) reaction, the enzyme forms a covalent enzyme DNA intermediate consisting of a 5′ phosphotyrosyl linkage between the…”
Get full text

TDP1 promotes assembly of non-homologous end joining protein complexes on DNA by Heo, Jinho, Li, Jing, Summerlin, Matthew, Hays, Annette, Katyal, Sachin, McKinnon, Peter J., Nitiss, Karin C., Nitiss, John L., Hanakahi, Leslyn A.

“…•End-processing factor TDP1 interacts with the NHEJ factor XLF to form a TDP1:XLF:DNA complex.•XLF stimulates TDP1 enzymatic activity on dsDNA.•TDP1 also…”
Get full text

Tyrosyl-DNA Phosphodiesterase (Tdp1) Participates in the Repair of Top2-Mediated DNA Damage by Nitiss, Karin C., Malik, Mobeen, He, Xiaoping, White, Stephen W., Nitiss, John L.

“…Agents targeting topoisomerases are active against a wide range of human tumors. Stabilization of covalent complexes, converting topoisomerases into…”
Get full text

Tdp2: a means to fixing the ends by Nitiss, John L, Nitiss, Karin C

“…  A key finding from the original identification of Tdp2 was that the protein was more active in processing 5' phosphotyrosyl-linked oligonucleotides, and that…”
Get full text

Topoisomerase assays by Nitiss, John L, Soans, Eroica, Rogojina, Anna, Seth, Aman, Mishina, Margarita

“…Topoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two…”
Get more information

Yeast Tdp1 regulates the fidelity of nonhomologous end joining by Bahmed, Karim, Nitiss, Karin C, Nitiss, John L

“…Tyrosyl-DNA-phosphodiesterase 1 (Tdp1) can disjoin peptides covalently bound to DNA. We assessed the role of Tdp1 in nonhomologous end joining (NHEJ) and found…”
Get full text

Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae by Tombline, Gregory, Millen, Jonathan I, Polevoda, Bogdan, Rapaport, Matan, Baxter, Bonnie, Van Meter, Michael, Gilbertson, Matthew, Madrey, Joe, Piazza, Gary A, Rasmussen, Lynn, Wennerberg, Krister, White, E Lucile, Nitiss, John L, Goldfarb, David S

“…A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that…”
Get full text

Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching by Wang, Yunke, Rakela, Samantha, Chambers, Jeremy W, Hua, Zi-Chun, Muller, Mark T, Nitiss, John L, Tse-Dinh, Yuk-Ching, Leng, Fenfei

“…DNA topoisomerases are essential enzymes for all living organisms and important targets for anticancer drugs and antibiotics. Although DNA topoisomerases have…”
Get full text

Roles of nonhomologous end-joining pathways in surviving topoisomerase II–mediated DNA damage by Malik, Mobeen, Nitiss, Karin C., Enriquez-Rios, Vanessa, Nitiss, John L.

“…Topoisomerase II is a target for clinically active anticancer drugs. Drugs targeting these enzymes act by preventing the religation of enzyme-DNA covalent…”
Get full text

UnTTrapping the ends： A new player in overcoming protein linked DNA damage by Bahmed, Karim, Nitiss, Karin C, Nitiss, John L

“…DNA topoisomerases carry out their reactions by generating transient covalent phosphotyrosine intermediates with DNA [ 1 ]. This reaction mechanism allows…”
Get full text