Search Results - "Nistico, Robert"

Aducanumab for Alzheimer’s disease: A regulatory perspective by Nisticò, Robert, Borg, John Joseph

“…On June 7th 2021, the Food and Drug Administration (FDA) granted approval for Aduhelm (aducanumab) for the treatment of Alzheimer’s disease under its…”
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Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? by Mango, Dalila, Nisticò, Robert

“…Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic…”
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The β-Secretase BACE1 in Alzheimer’s Disease by Hampel, Harald, Vassar, Robert, De Strooper, Bart, Hardy, John, Willem, Michael, Singh, Neeraj, Zhou, John, Yan, Riqiang, Vanmechelen, Eugeen, De Vos, Ann, Nisticò, Robert, Corbo, Massimo, Imbimbo, Bruno Pietro, Streffer, Johannes, Voytyuk, Iryna, Timmers, Maarten, Tahami Monfared, Amir Abbas, Irizarry, Michael, Albala, Bruce, Koyama, Akihiko, Watanabe, Naoto, Kimura, Teiji, Yarenis, Lisa, Lista, Simone, Kramer, Lynn, Vergallo, Andrea

“…BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all…”
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Targeting Microglia-Synapse Interactions in Alzheimer's Disease by Piccioni, Gaia, Mango, Dalila, Saidi, Amira, Corbo, Massimo, Nisticò, Robert

“…In this review, we focus on the emerging roles of microglia in the brain, with particular attention to synaptic plasticity in health and disease. We present…”
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A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease by Hampel, Harald, Caraci, Filippo, Cuello, A Claudio, Caruso, Giuseppe, Nisticò, Robert, Corbo, Massimo, Baldacci, Filippo, Toschi, Nicola, Garaci, Francesco, Chiesa, Patrizia A, Verdooner, Steven R, Akman-Anderson, Leyla, Hernández, Félix, Ávila, Jesús, Emanuele, Enzo, Valenzuela, Pedro L, Lucía, Alejandro, Watling, Mark, Imbimbo, Bruno P, Vergallo, Andrea, Lista, Simone

“…Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and represents one of the earliest pathomechanistic alterations throughout…”
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Acid-sensing ion channel 1a: a novel target in Alzheimer's disease? by Mango, Dalila, Nisticò, Robert

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SUMO: a (Oxidative) Stressed Protein by Feligioni, Marco, Nisticò, Robert

“…Redox species are produced during the physiological cellular metabolism of a normal tissue. In turn, their presence is also attributed to pathological…”
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Editorial: Neurotrophins Biodelivery to CNS: Innovative Approaches for Disease-Modifying Therapy by Triaca, Viviana, Imbimbo, Bruno Pietro, Nisticò, Robert

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Plasma ATN(I) classification and precision pharmacology in Alzheimer's disease by Imbimbo, Bruno P, Watling, Mark, Imbimbo, Camillo, Nisticò, Robert

“…Evaluating potential therapies for Alzheimer's disease (AD) depends on use of biomarkers for appropriate subject selection and monitoring disease progression…”
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Pharmacological targeting of microglia dynamics in Alzheimer’s disease: Preclinical and clinical evidence by Yousefizadeh, Atrin, Piccioni, Gaia, Saidi, Amira, Triaca, Viviana, Mango, Dalila, Nisticò, Robert

“…Numerous clinical trials of anti‐amyloid agents for Alzheimer’s disease (AD) were so far unsuccessful thereby challenging the validity of the amyloid…”
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The Involvement of Post-Translational Modifications in Alzheimer's Disease by Marcelli, Serena, Corbo, Massimo, Iannuzzi, Filomena, Negri, Lucia, Blandini, Fabio, Nistico, Robert, Feligioni, Marco

“…Alzheimer's disease (AD) is a neurodegenerative disorder recognized as the most common cause of chronic dementia among the ageing population. AD is…”
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Exploiting Focused Ultrasound to Aid Intranasal Drug Delivery for Brain Therapy by Barbato, Gaetano, Nisticò, Robert, Triaca, Viviana

“…Novel effective therapeutic strategies are needed to treat brain neurodegenerative diseases and to improve the quality of life of patients affected by…”
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Unlocking the secrets of dopamine in Alzheimer’s Disease by D’Amelio, Marcello, Nisticò, Robert

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Defining and assessing intrinsic capacity in older people: A systematic review and a proposed scoring system by López-Ortiz, Susana, Lista, Simone, Peñín-Grandes, Saúl, Pinto-Fraga, Jose, Valenzuela, Pedro L., Nisticò, Robert, Emanuele, Enzo, Lucia, Alejandro, Santos-Lozano, Alejandro

“…The World Health Organization has introduced the term ‘intrinsic capacity’ (IC) as a marker of healthy ageing. However, controversy exists on the definition…”
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Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence by Hampel, Harald, Nisticò, Robert, Seyfried, Nicholas T., Levey, Allan I., Modeste, Erica, Lemercier, Pablo, Baldacci, Filippo, Toschi, Nicola, Garaci, Francesco, Perry, George, Emanuele, Enzo, Valenzuela, Pedro L., Lucia, Alejandro, Urbani, Andrea, Sancesario, Giulia M., Mapstone, Mark, Corbo, Massimo, Vergallo, Andrea, Lista, Simone

“…[Display omitted] •A systems-level approach allows untangling AD upstream pathomechanistic alterations.•Multi-omics approaches hold the potential to generate…”
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Therapeutic potential of targeting hydrogen peroxide metabolism in the treatment of brain ischaemia by Armogida, Marta, Nisticò, Robert, Mercuri, Nicola Biagio

“…For many years after its discovery, hydrogen peroxide (H2O2) was viewed as a toxic molecule to human tissues; however, in light of recent findings, it is being…”
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Targeting Synaptic Dysfunction in Alzheimer’s Disease Therapy by Nisticò, Robert, Pignatelli, Marco, Piccinin, Sonia, Mercuri, Nicola B., Collingridge, Graham

“…In the past years, major efforts have been made to understand the genetics and molecular pathogenesis of Alzheimer’s disease (AD), which has been translated…”
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Effects of physical activity and exercise interventions on Alzheimer’s disease: an umbrella review of existing meta-analyses by López-Ortiz, Susana, Lista, Simone, Valenzuela, Pedro L., Pinto-Fraga, José, Carmona, Ricardo, Caraci, Filippo, Caruso, Giuseppe, Toschi, Nicola, Emanuele, Enzo, Gabelle, Audrey, Nisticò, Robert, Garaci, Francesco, Lucia, Alejandro, Santos-Lozano, Alejandro

“…Introduction During the last decade, physical activity (PA) (or “exercise”) has been identified as one of the main modifiable factors that influence the…”
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Are we close to using Alzheimer blood biomarkers in clinical practice? by Imbimbo, Bruno P, Lista, Simone, Imbimbo, Camillo, Nisticò, Robert

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Alzheimer’s disease: understanding homeostasis deregulation to foster development of effective therapies by Nisticò, Robert, Peineau, Stéphane

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