Search Results - "Nisticò, Paola"

Polyphenols: Immunomodulatory and Therapeutic Implication in Colorectal Cancer by Mileo, Anna Maria, Nisticò, Paola, Miccadei, Stefania

“…Polyphenolic compounds, widely present in fruits, vegetables, and cereals, have potential benefits for human health and are protective agents against the…”
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Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy by Galli, Filippo, Aguilera, Jesus Vera, Palermo, Belinda, Markovic, Svetomir N, Nisticò, Paola, Signore, Alberto

“…Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex…”
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Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology by Spada, Sheila, Tocci, Annalisa, Di Modugno, Francesca, Nisticò, Paola

“…Deciphering extracellular matrix (ECM) composition and architecture may represent a novel approach to identify diagnostic and therapeutic targets in cancer…”
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Deciphering the loop of epithelial-mesenchymal transition, inflammatory cytokines and cancer immunoediting by Sistigu, Antonella, Di Modugno, Francesca, Manic, Gwenola, Nisticò, Paola

“…Graphical abstract…”
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Biological mechanisms linked to inflammation in cancer: Discovery of tumor microenvironment-related biomarkers and their clinical application in solid tumors by Nisticò, Paola, Ciliberto, Gennaro

“…Our view of cancer biology radically shifted from a “cancer-cell-centric” vision to a view of cancer as an organ disease. The concept that genetic and/or…”
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T-cell repertoire diversity: friend or foe for protective antitumor response? by Porciello, Nicla, Franzese, Ornella, D'Ambrosio, Lorenzo, Palermo, Belinda, Nisticò, Paola

“…Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach to investigate autologous and treatment-induced antitumor immune response…”
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3D models in the new era of immune oncology: focus on T cells, CAF and ECM by Di Modugno, Francesca, Colosi, Cristina, Trono, Paola, Antonacci, Giuseppe, Ruocco, Giancarlo, Nisticò, Paola

“…Immune checkpoint inhibitor therapy has changed clinical practice for patients with different cancers, since these agents have demonstrated a significant…”
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Transcription factors in fibroblast plasticity and CAF heterogeneity by Melchionna, Roberta, Trono, Paola, Di Carlo, Anna, Di Modugno, Francesca, Nisticò, Paola

“…In recent years, research focused on the multifaceted landscape and functions of cancer-associated fibroblasts (CAFs) aimed to reveal their heterogeneity and…”
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A Systematic Review on the Impact of Hypofractionated and Stereotactic Radiotherapy on Immune Cell Subpopulations in Cancer Patients by Takanen, Silvia, Bottero, Marta, Nisticò, Paola, Sanguineti, Giuseppe

“…We investigated how hypofractionated radiotherapy (HFRT) and stereotactic body radiotherapy (SBRT) may impact immune cells in different type of tumors. A…”
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Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases by Nisticò, Paola, Bissell, Mina J, Radisky, Derek C

“…Epithelial-mesenchymal transition (EMT) is a physiological process in which epithelial cells acquire the motile and invasive characteristics of mesenchymal…”
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Strategies for Efficient Targeting of Tumor Collagen for Cancer Therapy by Baldari, Silvia, Di Modugno, Francesca, Nisticò, Paola, Toietta, Gabriele

“…The tumor stroma, which comprises stromal cells and non-cellular elements, is a critical component of the tumor microenvironment (TME). The dynamic…”
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Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links by Melchionna, Roberta, Trono, Paola, Tocci, Annalisa, Nisticò, Paola

“…Human tissues, to maintain their architecture and function, respond to injuries by activating intricate biochemical and physical mechanisms that regulates…”
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Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis by Principe, Moitza, Borgoni, Simone, Cascione, Mariafrancesca, Chattaragada, Michelle Samuel, Ferri-Borgogno, Sammy, Capello, Michela, Bulfamante, Sara, Chapelle, Jennifer, Di Modugno, Francesca, Defilippi, Paola, Nisticò, Paola, Cappello, Paola, Riganti, Chiara, Leporatti, Stefano, Novelli, Francesco

“…We have previously shown that in pancreatic ductal adenocarcinoma (PDA) cells, the glycolytic enzyme alpha-enolase (ENO1) also acts as a plasminogen receptor…”
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Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors by Di Modugno, Francesca, Iapicca, Pierluigi, Boudreau, Aaron, Mottolese, Marcella, Terrenato, Irene, Perracchio, Letizia, Carstens, Russ P, Santoni, Angela, Bissell, Mina J, Nisticò, Paola

“…Human mena (hMENA), a member of the actin cytoskeleton regulators Ena/VASP, is overexpressed in high-risk preneoplastic lesions and in primary breast tumors…”
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CD28/PD1 co-expression: dual impact on CD8 + T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response by Palermo, Belinda, Franzese, Ornella, Frisullo, Giuseppe, D'Ambrosio, Lorenzo, Panetta, Mariangela, Campo, Giulia, D'Andrea, Daniel, Sperduti, Isabella, De Nicola, Francesca, Goeman, Frauke, Gallina, Filippo, Visca, Paolo, Facciolo, Francesco, Nisticò, Paola

“…Immune checkpoint blockade (ICB) has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients, although most patients develop mechanisms…”
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Cancer immunity and immunotherapy beyond COVID-19 by Bellone, Matteo, Brevi, Arianna, Bronte, Vincenzo, Dusi, Silvia, Ferrucci, Pier Francesco, Nisticò, Paola, Rosato, Antonio, Russo, Vincenzo, Sica, Antonio, Toietta, Gabriele, Colombo, Mario Paolo

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Stereotactic Ablative Radiation Therapy in 3 Fractions Induces a Favorable Systemic Immune Cell Profiling in Prostate Cancer Patients by Palermo, Belinda, Bottero, Marta, Panetta, Mariangela, Faiella, Adriana, Sperduti, Isabella, Masi, Serena, Frisullo, Giuseppe, Foddai, Maria Laura, Cordone, Iole, Nisticò, Paola, Sanguineti, Giuseppe

“…The impact of radiotherapy (RT) on immune cell status in prostate cancer (PCa) is only partially determined. The aim of this study was to assess the effect of…”
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ADA/CD26 axis increases intra-tumor PD-1 + CD28 + CD8 + T-cell fitness and affects NSCLC prognosis and response to ICB by Franzese, Ornella, Palermo, Belinda, Frisullo, Giuseppe, Panetta, Mariangela, Campo, Giulia, D'Andrea, Daniel, Sperduti, Isabella, Taje, Riccardo, Visca, Paolo, Nisticò, Paola

“…Improving cancer immunotherapy efficacy hinges on identifying key T-cell populations critical for tumor control and response to Immune Checkpoint Blockade…”
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Trajectory of PD-L1 expression in a patient underwent neoadjuvant chemo-immunotherapy for resectable NSCLC by Gallina, Filippo Tommaso, Balzano, Vittoria, Porciello, Nicla, Tajè, Riccardo, Forcella, Daniele, Melis, Enrico, Letizia Cecere, Fabiana, Fusco, Francesca, Buglioni, Simonetta, Visca, Paolo, Nisticò, Paola, Cappuzzo, Federico, Spicer, Jonathan

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Integrating AI-Powered Digital Pathology and Imaging Mass Cytometry Identifies Key Classifiers of Tumor Cells, Stroma, and Immune Cells in Non-Small Cell Lung Cancer by Rigamonti, Alessandra, Viatore, Marika, Polidori, Rebecca, Rahal, Daoud, Erreni, Marco, Fumagalli, Maria Rita, Zanini, Damiano, Doni, Andrea, Putignano, Anna Rita, Bossi, Paola, Voulaz, Emanuele, Alloisio, Marco, Rossi, Sabrina, Zucali, Paolo Andrea, Santoro, Armando, Balzano, Vittoria, Nisticò, Paola, Feuerhake, Friedrich, Mantovani, Alberto, Locati, Massimo, Marchesi, Federica

“…Artificial intelligence (AI)-powered approaches are becoming increasingly used as histopathologic tools to extract subvisual features and improve diagnostic…”
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