Search Results - "Nistala, K"

The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes by Rider, L. G., Nistala, K.

“…The aim of this review was to summarize recent advances in the understanding of the clinical and autoantibody phenotypes, their associated outcomes and the…”
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CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells by Oleinika, K., Rosser, E. C., Matei, D. E., Nistala, K., Bosma, A., Drozdov, I., Mauri, C.

“…Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg…”
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Clinical assessment and core outcome variables are poor predictors of hip arthritis diagnosed by MRI in juvenile idiopathic arthritis by Nistala, K., Babar, J., Johnson, K., Campbell-Stokes, P., Foster, K., Ryder, C., McDonagh, J. E.

“…Objectives. To compare the diagnostic performance of clinical assessment against magnetic resonance imaging (MRI) diagnosed hip arthritis in a juvenile…”
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Prevalence of SAP gene defects in male patients diagnosed with common variable immunodeficiency by EASTWOOD, D., GILMOUR, K. C., NISTALA, K., MEANEY, C., CHAPEL, H., SHERRELL, Z., WEBSTER, A. D., DAVIES, E. G., JONES, A., GASPAR, H. B.

“…SUMMARY The molecular basis of common variable immunodeficiency (CVID) is undefined, and diagnosis requires exclusion of other diseases including X‐linked…”
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Should preterm neonates with a central venous catheter and coagulase negative staphylococcal bacteraemia be treated without removal of the catheter? by Nistala, K, Nicholl, R

“…Table 4 Coagulase negative staphylococcal bacteraemia in preterm neonates with a central venous catheter Citation Study group Study type (level of evidence)…”
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Co-existent sickle cell disease and juvenile rheumatoid arthritis. Two cases with delayed diagnosis and severe destructive arthropathy by NISTALA, Kiran, MURRAY, Kevin J

“…We describe 2 pediatric patients with sickle cell disease (SCD) who developed seropositive juvenile rheumatoid arthritis (JRA). Both patients have severe joint…”
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Risks of treating infected neonatal lines by Nicholl, R, Nistala, K

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CD39: a regulatory role in childhood arthritis by Moncrieffe, H, Nistala, K, Hunter, P, Kamhieh, Y, Wedderburn, L

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7.2 Interleukin-17 (IL-17) secreting cells in synovial fluid express the "Th17" master transcription factor RORC and their numbers correlate with CCL20 levels within the joint by Nistala, K, Hunter, P, Sala-Soriano, E, Diss, J, Wedderburn, LR

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X‐Linked lymphoproliferative disease: three atypical cases by Nistala, K., Gilmour, K. C., Cranston, T., Davies, E. G., Goldblatt, D., Gaspar, H. B., Jones, A. M.

“…Common variable immunodeficiency (CVID) is the most frequently occurring primary immunodeficiency in both children and adults. The molecular basis of CVID has…”
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Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis by Nistala, Kiran, Wedderburn, Lucy R.

“…Inflammatory T cells are thought to be central to the pathology of autoimmune arthritis. Th17 cells, CD4 T cells that secrete the pro-inflammatory cytokine…”
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14.4 Oligoarticular Juvenile Idiopathic Arthritis (JIA): can extension be predicted? by Hunter, PJ, Jina, N, Nistala, K, Eddaoudi, A, Hubank, M, Wedderburn, LR

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Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis by Ruperto, Nicolino, Brunner, Hermine I, Quartier, Pierre, Constantin, Tamás, Wulffraat, Nico, Horneff, Gerd, Brik, Riva, McCann, Liza, Kasapcopur, Ozgur, Rutkowska-Sak, Lidia, Schneider, Rayfel, Berkun, Yackov, Calvo, Inmaculada, Erguven, Muferet, Goffin, Laurence, Hofer, Michael, Kallinich, Tilmann, Oliveira, Sheila K, Uziel, Yosef, Viola, Stefania, Nistala, Kiran, Wouters, Carine, Cimaz, Rolando, Ferrandiz, Manuel A, Flato, Berit, Gamir, Maria Luz, Kone-Paut, Isabelle, Grom, Alexei, Magnusson, Bo, Ozen, Seza, Sztajnbok, Flavio, Lheritier, Karine, Abrams, Ken, Kim, Dennis, Martini, Alberto, Lovell, Daniel J

“…In two placebo-controlled trials, canakinumab, an anti-interleukin-1β monoclonal antibody, achieved a response, prevented flares, and allowed glucocorticoid…”
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Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment by Nistala, Kiran, Adams, Stuart, Cambrook, Helen, Ursu, Simona, Olivito, Biagio, de Jager, Wilco, Evans, Jamie G., Cimaz, Rolando, Bajaj-Elliott, Mona, Wedderburn, Lucy R., Mitchison, N. Avrion

“…In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of inflammation. In human arthritis the majority of IL-17–secreting…”
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High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population by Moncrieffe, Halima, Nistala, Kiran, Kamhieh, Yasmine, Evans, Jamie, Eddaoudi, Ayad, Eaton, Simon, Wedderburn, Lucy R

“…The ectonucleotidase CD39 has recently been described as being highly expressed on regulatory Foxp3(+) CD4 T cells. Through hydrolysis of proinflammatory…”
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Th1 and Th17 cell subpopulations are enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis by OMOYINMI, Ebun, HAMAOUI, Raja, PESENACKER, Anne, NISTALA, Kiran, MONCRIEFFE, Halima, URSU, Simona, WEDDERBURN, Lucy R, WOO, Patricia

“…The role of the adaptive immune system has not been explored in detail compared with the innate immune system in systemic JIA (sJIA) pathogenesis. The aim of…”
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Effective induction therapy for anti-SRP associated myositis in childhood: A small case series and review of the literature by Binns, E L, Moraitis, E, Maillard, S, Tansley, S, McHugh, N, Jacques, T S, Wedderburn, L R, Pilkington, C, Yasin, S A, Nistala, K

“…Anti-Signal Recognition Particle associated myopathy is a clinically and histopathologically distinct subgroup of Juvenile Idiopathic Inflammatory Myositis,…”
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PReS-FINAL-1020: Dysregulation of the peripheral blood D cell compartment is associated with disease activity in juvenile dermatomyositis by Piper, C, Varsani, H, Arnold, K, Wedderburn, L, Mauri, C, Nistala, K

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PReS-FINAL-2069: T cells secreting granulocyte-macrophage colony stimulating factor (GM-CSF) within the inflammed joint originate from an "EX-Th17" population by Nistala, K, Piper, C, Pesenacker, A, Bending, D, Thirugnanabalan, B, Wedderburn, L

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The role of Th17 cells in juvenile idiopathic arthritis by Nistala, K

“…Autoimmune arthritis in childhood, know as juvenile idiopathic arthritis (JIA), has a heterogeneity, ranging from monoarthritis to recalcitrant polyarthritis,…”
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