Search Results - "Nissan, Yassin M."

New proapoptotic chemotherapeutic agents based on the quinolone-3-carboxamide scaffold acting by VEGFR-2 inhibition by El-Fakharany, Zeinab S., Nissan, Yassin M., Sedky, Nada K., Arafa, Reem K., Abou-Seri, Sahar M.

“…In the current study, we designed and synthesized a series of new quinoline derivatives 10a-p as antiproliferative agents targeting cancer through inhibition…”
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Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers by El Newahie, Aliya M S, Nissan, Yassin M, Ismail, Nasser S M, Abou El Ella, Dalal A, Khojah, Sohair M, Abouzid, Khaled A M

“…The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents. Three series of quinoxaline derivatives were synthesized…”
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Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking by Ghorab, Mostafa M., Alsaid, Mansour S., El-Gaby, Mohamed S. A., Elaasser, Mahmoud M., Nissan, Yassin M.

“…Background Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are used…”
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Synthesis and anticancer activity of some novel trifluoromethylquinolines carrying a biologically active benzenesulfonamide moiety by Al-Dosari, Mohammed S., Ghorab, Mostafa M., AlSaid, Mansour S., Nissan, Yassin M., Ahmed, Abdulkareem B.

“…Several trifluoromethylquinoline derivatives containing a biologically active benzenesulfonamide moiety 2–14, 16, urea derivatives 15, 17, 4-isothiocyanate 18…”
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Dapson in heterocyclic chemistry, part VIII: synthesis, molecular docking and anticancer activity of some novel sulfonylbiscompounds carrying biologically active 1,3-dihydropyridine, chromene and chromenopyridine moieties by Al-Said, Mansour S, Ghorab, Mostafa M, Nissan, Yassin M

“…Several new sulfonebiscompounds having a biologically active 1,2-dihydropyridine-2-one 3–19, acrylamide 20, chromene 21, 22 and chromenopyridine 23, 24…”
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Novel brominated quinoline and pyrimidoquinoline derivatives as potential cytotoxic agents with synergistic effects of γ-radiation by Ghorab, Mostafa M., Ragab, Fatma A., Heiba, Helmi I., Nissan, Yassin M., Ghorab, Walid M.

“…New quinoline derivatives 6 , 7 and 19 , pyrimidoquinoline derivatives 8–16 and triazolopyrimidoquinoline derivatives 17 and 18 bearing a bromo-substituent…”
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New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES by Hassan, Ghaneya S., Abdel Rahman, Doaa E., Abdelmajeed, Esraa A., Refaey, Rana H., Alaraby Salem, M., Nissan, Yassin M.

“…New pyrazole derivatives 2–5 were synthesized and evaluated for their COX-1 and COX-2 inhibitory activity in vitro. All compounds showed good inhibitory…”
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Repurposing of renin inhibitors as SARS-COV-2 main protease inhibitors: A computational study by Refaey, Rana H., El-Ashrey, Mohamed K., Nissan, Yassin M.

“…The COVID-19 pandemic has urged for the repurposing of existing drugs for rapid management and treatment. Renin inhibitors down regulation of ACE2, which is an…”
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Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases by Khalil, Omneya M., Kamal, Aliaa M., Bua, Silvia, El Sayed Teba, Heba, Nissan, Yassin M., Supuran, Claudiu T.

“…A series of novel sulfonamide derivatives bearing pyrrole and pyrrolopyrimidine scaffolds were synthesized and screened as carbonic anhydrase inhibitors. The…”
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Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties by Ghorab, Mostafa M., Alsaid, Mansour S., Ceruso, Mariangela, Nissan, Yassin M., Supuran, Claudiu T.

“…A series of novel pyrroles, pyrrolopyrimidines, pyrazolopyrrolopyrimidine, triazolopyrrolopyrimidines, tetrazolopyrrolopyrimidine, triazinopyrrolopyrimidines…”
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Pharmacophore based virtual screening for natural product database revealed possible inhibitors for SARS-COV-2 main protease by El-Ashrey, Mohamed K., Bakr, Riham O., Fayed, Marwa A.A., Refaey, Rana H., Nissan, Yassin M.

“…The challenge continues globally triggered by the absence of an approved antiviral drug against COVID-19 virus infection necessitating global concerted efforts…”
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Design, synthesis, and biological evaluation with molecular dynamics study of novel pyrazolo[3,4-]pyrimidine derivatives as anti-cancer agents by Shaban, Rania M, Samir, Nermin, Nissan, Yassin M, Abouzid, Khaled A. M

“…In continuation of our efforts to discover new structural chemotypes with significant chemotherapeutic activities, a novel series of pyrazolo[3,4- d…”
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Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives by Mahmoud, Walaa R., Nissan, Yassin M., Elsawah, Menna M., Refaey, Rana H., Ragab, Mai F., Amin, Kamilia M.

“…Twenty four 6-aminocoumarin based derivatives were synthesized according to two schemes. All the compounds were screened for their acetylcholinesterase…”
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Synthesis, Molecular Docking, and Biological Evaluation of Some Novel Hydrazones and Pyrazole Derivatives as Anti-inflammatory Agents by Mohammed, Khaled O., Nissan, Yassin M.

“…2‐Hydrazinyl‐N‐(4‐sulfamoylphenyl)acetamide 3 was the key intermediate for the synthesis of novel hydrazones 4–10 and pyrazole derivatives 11–17. All compounds…”
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Synthesis and in vitro investigation of novel cytotoxic pyrimidine and pyrazolopyrimidne derivatives showing apoptotic effect by Ragab, Fatma A., Nissan, Yassin M., Seif, Emad M., Maher, Ahmed, Arafa, Reem K.

“…[Display omitted] •A series of novel pyrimidines have been synthesized and tested for their in vitro cytotoxic activity against 60 tumor cell lines by NCI.•5d…”
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Synthesis and biological evaluation of new coumarin derivatives as cytotoxic agents by Ragab, Fatma A., Eissa, Amal A. M., Fahim, Samar H., Salem, Mohammad A., Gamal, Mona A., Nissan, Yassin M.

“…New coumarin derivatives 9a–f, 10a–e, and 11a–f were synthesized and evaluated for their cytotoxic activity against a human breast cancer cell line (MCF‐7)…”
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Design, synthesis and biological evaluation of some novel sulfonamide derivatives as apoptosis inducers by Mohamed, Khaled O., Nissan, Yassin M., El-Malah, Afaf A., Ahmed, Wafaa A., Ibrahim, Dina M., Sakr, Tamer M., Motaleb, Mohamed A.

“…Several novel thiazolidinone and fused thiazolidinone derivatives bearing benzenesulfonamide moiety were synthesized and confirmed via spectral and elemental…”
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Novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl)-benzenesulfonamides as cytotoxic and radiosensitizing agents by Ghorab, Mostafa M., Ragab, Fatma A., Heiba, Helmy I., Agha, Hebaallah M., Nissan, Yassin M.

“…A series of novel 4-(4-substituted-thiazol-2-ylamino)-N-(pyridin-2-yl) benzene-sulfonamides were synthesized and screened for their cytotoxic activity against…”
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Novel pyrazolopyrimidines: Synthesis, in vitro cytotoxic activity and mechanistic investigation by Hassan, Ghaneya S., Abdel Rahman, Doaa E., Nissan, Yassin M., Abdelmajeed, Esraa A., Abdelghany, Tamer M.

“…A series of novel pyrazolo[3,4-d]pyrimidines bearing benzenesulfonamide moiety 5a-f, 6 and 7 were synthesized. Cytotoxic screening was conducted against MCF-7…”
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New benzenesulfonamide scaffold-based cytotoxic agents: Design, synthesis, cell viability, apoptotic activity and radioactive tracing studies by Nissan, Yassin M., Mohamed, Khaled O., Ahmed, Wafaa A., Ibrahim, Dina M., Sharaky, Marwa M., Sakr, Tamer M., Motaleb, Mohamed A., Maher, Ahmed, Arafa, Reem K.

“…[Display omitted] •New thiazolidinone, thiazinone and dithiazepinone-benzenesulfonamides as cytotoxic agents.•Effect of 5a-d on MCF-7 and HepG2 cell cycle…”
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