Search Results - "Nishtala, Prasad S."

Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review by Salahudeen, Mohammed Saji, Duffull, Stephen B, Nishtala, Prasad S

“…The cumulative effect of taking multiple medicines with anticholinergic properties termed as anticholinergic burden can adversely impact cognition, physical…”
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Challenges and enablers of deprescribing : a general practitioner perspective by Ailabouni, Nagham J

“…Explores challenges faced by general practitioners (GP) to deprescribing in the residential care setting, the enablers that facilitate deprescribing in the…”
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Safety outcomes associated with the moderna COVID-19 vaccine (mRNA-1273): a literature review by Shabu, Angel, Nishtala, Prasad S.

“…Current safety data from Phase 3 clinical trials have concluded that apart from transient local and systemic reactions, no safety concerns were identified for…”
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Analysis of the adverse events following the mRNA-1273 COVID-19 vaccine by Shabu, Angel, Nishtala, Prasad S.

“…OBJECTIVEThis study aims to characterize the adverse events (AEs) following the administration of the mRNA-1273 COVID-19 vaccine from the Vaccine Adverse Event…”
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Temporal Trends in Polypharmacy and Hyperpolypharmacy in Older New Zealanders over a 9-Year Period: 2005–2013 by Nishtala, Prasad S, Salahudeen, Mohammed Saji

“…Polypharmacy and hyperpolypharmacy are proxy indicators for inappropriate medicine use. Inappropriate medicine use in older people leads to adverse clinical…”
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Anticholinergics: theoretical and clinical overview by Nishtala, Prasad S, Salahudeen, Mohammed Saji, Hilmer, Sarah N

“…Anticholinergics are a class of medicines that block the neurotransmitter, acetylcholine, in the brain and peripheral tissues. Medicines with anticholinergic…”
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Serum Anticholinergic Activity and Cognitive and Functional Adverse Outcomes in Older People: A Systematic Review and Meta-Analysis of the Literature by Salahudeen, Mohammed Saji, Chyou, Te-Yuan, Nishtala, Prasad S

“…Studies have reported associations between serum anticholinergic activity (SAA) and decline in cognitive performance, delirium, and functional impairment. The…”
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Deprescribing Anticholinergic and Sedative Drugs to Reduce Polypharmacy in Frail Older Adults Living in the Community: A Randomized Controlled Trial by Jamieson, Hamish, Nishtala, Prasad S, Bergler, Hans Ulrich, Weaver, Susan K, Pickering, John W, Ailabouni, Nagham J, Abey-Nesbit, Rebecca, Gullery, Carolyn, Deely, Joanne, Gee, Susan B, Hilmer, Sarah N, Mangin, Dee

“…Abstract Background Polypharmacy is associated with poor outcomes in older adults. Targeted deprescribing of anticholinergic and sedative medications may…”
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Risk of antimicrobial-associated organ injury among the older adults: a systematic review and meta-analysis by Chinzowu, Tichawona, Roy, Sandipan, Nishtala, Prasad S

“…Abstract Background Older adults (aged 65 years and above) constitute the fastest growing population cohort in the western world. There is increasing evidence…”
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Application of machine learning approaches in predicting clinical outcomes in older adults – a systematic review and meta-analysis by Olender, Robert T, Roy, Sandipan, Nishtala, Prasad S

“…Abstract Background Machine learning-based prediction models have the potential to have a considerable positive impact on geriatric care. Design Systematic…”
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Antimicrobial-associated organ injury among the elderly: a systematic review and meta-analysis protocol by Chinzowu, Tichawona, Roy, Sandipan, Nishtala, Prasad S

“…IntroductionOlder adults (aged 65 years and above) constitute the fastest growing population cohort in the western world. There is increasing evidence that the…”
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The association between anticholinergic burden and mobility: a systematic review and meta-analyses by Phutietsile, Geofrey O, Fotaki, Nikoletta, Jamieson, Hamish A, Nishtala, Prasad S

“…As people age, they accumulate several health conditions, requiring the use of multiple medications (polypharmacy) to treat them. One of the challenges with…”
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Safety of fluoxetine use in children and adolescents: a disproportionality analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) database by Christodoulos, Iole N., Chyou, Te-yuan, Nishtala, Prasad S.

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Zopiclone Use and Risk of Fractures in Older People: Population-Based Study by Nishtala, Prasad S., PhD, Chyou, Te-yuan, PhD

“…Abstract Objectives The primary objective was to evaluate the risk of fractures associated with use of zopiclone, a new Z-hypnotic, in a population-based…”
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Population‐based study examining the utilization of preventive medicines by older people in the last year of life by Narayan, Sujita W, Nishtala, Prasad S

“…Aim To examine the patterns of preventive medicines (PM) use in the last year of life of older adults. Methods This study cohort included individuals (n = 99…”
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Deprescribing to reduce polypharmacy: study protocol for a randomised controlled trial assessing deprescribing of anticholinergic and sedative drugs in a cohort of frail older people living in the community by Bergler, Ulrich, Ailabouni, Nagham J, Pickering, John W, Hilmer, Sarah N, Mangin, Dee, Nishtala, Prasad S, Jamieson, Hamish

“…Targeted deprescribing of anticholinergic and sedative medications in older people may improve their health outcomes. This trial will determine if…”
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Potentially inappropriate medicines in a cohort of community-dwelling older people in New Zealand by Nishtala, Prasad S, Bagge, Michael L, Campbell, A John, Tordoff, June M

“…Aim To examine independent factors associated with potentially inappropriate medicines (PIM) among 316 community‐dwelling people aged ≥75 years living in…”
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DEFEAT-polypharmacy: deprescribing anticholinergic and sedative medicines feasibility trial in residential aged care facilities by Ailabouni, Nagham, Mangin, Dee, Nishtala, Prasad S.

“…Background Prolonged use of anticholinergic and sedative medicines is correlated with worsening cognition and physical function decline. Deprescribing is a…”
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Psychotropic Prescribing in Long-Term Care Facilities: Impact of Medication Reviews and Educational Interventions by Nishtala, Prasad S., M.Pharm, McLachlan, Andrew J., Ph.D, Bell, J Simon, Ph.D, Chen, Timothy F., Ph.D

“…The objective of this literature review was to evaluate the evidence pertaining to the impact of medication reviews and/or educational interventions on…”
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Antihypertensive medicines utilization: A decade‐long nationwide study of octogenarians, nonagenarians and centenarians by Narayan, Sujita W, Nishtala, Prasad S

“…Aim Gaining an insight into the utilization of antihypertensive medicines against a background of evolving hypertension treatment guidelines that might not be…”
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