Search Results - "Nishizuka, Y."

Discovery and Prospect of Protein Kinase C Research: Epilogue by Nishizuka, Yasutomi

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The Protein Kinase C Family and Lipid Mediators for Transmembrane Signaling and Cell Regulation by Nishizuka, Yasutomi

“…This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan…”
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Taxonomy and function of C1 protein kinase C homology domains by Hurley, James H., Newton, Alexandra C., Parker, Peter J., Blumberg, Peter M., Nishizuka, Yasutomi

“…C1 domains are compact α/β structural units of about 50 amino acids which tightly bind two zinc ions. These domains were first discovered as the loci of…”
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Perspectives on the role of protein kinase C in stimulus-response coupling by Nishizuka, Y

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Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties by Ono, Y, Fujii, T, Ogita, K, Kikkawa, U, Igarashi, K, Nishizuka, Y

“…The primary structure of the zeta subspecies of rat brain protein kinase C was deduced from its overlapping cDNAs. The zeta subspecies of protein kinase C…”
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The structure, expression, and properties of additional members of the protein kinase C family by Ono, Y, Fujii, T, Ogita, K, Kikkawa, U, Igarashi, K, Nishizuka, Y

“…In rat brain three members of the protein kinase C family encoded by cDNAs termed delta, epsilon, and zeta were newly identified by molecular cloning and…”
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Modulation of ion channel activity: a key function of the protein kinase C enzyme family by Shearman, M S, Sekiguchi, K, Nishizuka, Y

“…The considerable volume of data now available strongly implicates the modulation of ion channel activity as a key function of the PKC enzyme family. In some…”
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Phorbol Ester Binding to Protein Kinase C Requires a Cysteine-Rich Zinc-Finger-Like Sequence by Ono, Yoshitaka, Fujii, Tomoko, Igarashi, Koichi, Kuno, Takayoshi, Tanaka, Chikako, Kikkawa, Ushio, Nishizuka, Yasutomi

“…Protein kinase C normally has a tandem repeat of a characteristic cysteine-rich sequence in C1, the conserved region of the regulatory domain. These sequences…”
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Limited Proteolysis of Protein Kinase C Subspecies by Calcium-dependent Neutral Protease (Calpain) by Kishimoto, A, Mikawa, K, Hashimoto, K, Yasuda, I, Tanaka, S, Tominaga, M, Kuroda, T, Nishizuka, Y

“…Limited proteolysis of three distinct subspecies of protein kinase C (Ca2+/phospholipid-dependent enzyme, PKC), types I (γ), II (βI and βII), and III (α), with…”
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Cell Division Arrest Induced by Phorbol Ester in CHO Cells Overexpressing Protein Kinase C-δ Subspecies by Watanabe, Tatsuya, Ono, Yoshitaka, Taniyama, Yoshio, Hazama, Kumiko, Igarashi, Koichi, Ogita, Kouji, Kikkawa, Ushio, Nishizuka, Yasutomi

“…Several lines of CHO cells stably overexpressing protein kinase C (PKC) subspecies to various extents were established by the DNA-mediated transfer. Upon…”
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Synergistic Action of Diacylglycerol and Unsaturated Fatty Acid for Protein Kinase C Activation: Its Possible Implications by Shinomura, Tetsutaro, Asaoka, Yoshinori, Oka, Masahiro, Yoshida, Kimishisa, Nishizuka, Yasutomi

“…Kinetic properties of the purified α, β, and γ subspecies of protein kinase C (PKC) to respond to diacylglycerol, phosphatidylserine (PtdSer), and Ca2+were…”
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Isolation and Characterization of the ε Subspecies of Protein Kinase C from Rat Brain by Koide, Hiroshi, Ogita, Kouji, Kikkawa, Ushio, Nishizuka, Yasutomi

“…The ε subspecies of protein kinase C (ε PKC) was purified to near homogeneity from the soluble fraction of rat brain by successive chromatographies on…”
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Distribution of protein kinase C-like immunoreactive neurons in rat brain by Saito, N, Kikkawa, U, Nishizuka, Y, Tanaka, C

“…Distribution of protein kinase C in the CNS of rat is presented based on immunohistochemical analysis with monoclonal antibodies against this protein kinase…”
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters by Castagna, M, Takai, Y, Kaibuchi, K, Sano, K, Kikkawa, U, Nishizuka, Y

“…Tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) directly activate in vitro Ca2+-activated, phospholipid-dependent protein…”
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Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters by Kikkawa, U, Takai, Y, Tanaka, Y, Miyake, R, Nishizuka, Y

“…A tumor-promoting phorbol ester, [3H]phorbol-12,13-dibutyrate, may bind to a homogeneous preparation of Ca2+-activated, phospholipid-dependent protein kinase…”
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Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease by Kishimoto, A, Kajikawa, N, Shiota, M, Nishizuka, Y

“…A Ca2+-dependent protease I), which hydrolyzes casein at Ca2+ concentrations lower than the 10(-5) M range, is purified roughly 4000-fold from the soluble…”
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Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover by Kishimoto, A, Takai, Y, Mori, T, Kikkawa, U, Nishizuka, Y

“…Ca2+-activated, phospholipid-dependent protein kinase from various mammalian tissues (Takai, Y., Kishimoto, A., Iwasa, Y., Kawahara, Y., Mori, T., and…”
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The Protein Kinase C Isoforms Leading to MAP-Kinase Activation in CHO Cells by Yamaguchi, K., Ogita, K., Nakamura, S., Nishizuka, Y.

“…Stimulation of CHO cells with phorbol ester caused transient activation of mitogen-activated protein kinase (MAP-kinases with 42 and 44 kDa). A similar…”
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Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation by Kaibuchi, K, Takai, Y, Sawamura, M, Hoshijima, M, Fujikura, T, Nishizuka, Y

“…When human platelets were stimulated by synthetic diacylglycerol such as 1-oleoyl-2-acetyl-glycerol, which was a potent activator in vitro of Ca2+-activated,…”
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The Protein Kinase C Family: Heterogeneity and its Implications by Kikkawa, U, Kishimoto, A, Nishizuka, Y

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