Search Results - "Nishiyama, Kuniyuki"

Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study by Kyohara, Mayu, Miyashita, Daisuke, Inoue, Ryota, Nishiyama, Kuniyuki, Tsuno, Takahiro, Okuyama, Tomoko, Togashi, Yu, Terauchi, Yasuo, Shirakawa, Jun

“…Plasma and liver SerpinB1 levels are elevated in mice with insulin resistance and promote β-cell proliferation in human islets. We measured serum SerpinB1…”
Get full text

Abdominal aortic calcification is associated with Fibrosis‐4 index and low body mass index in type 2 diabetes patients: A retrospective cross‐sectional study by Togashi, Yu, Miyashita, Daisuke, Tsuno, Takahiro, Inoue, Ryota, Okuyama, Tomoko, Kyohara, Mayu, Nishiyama, Kuniyuki, Arai, Masanori, Kanematsu, Kenta, Kanataki, Soichiro, Terauchi, Yasuo, Shirakawa, Jun

“…Aims/Introduction This study aimed to clarify the nature of the relationship between the abdominal aortic calcification (AAC) grade and the presence of…”
Get full text

LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand by Kurihara, Yuji, Iketani, Masumi, Ito, Hiromu, Nishiyama, Kuniyuki, Sakakibara, Yusuke, Goshima, Yoshio, Takei, Kohtaro

“…Axon growth inhibitors such as Nogo proteins, myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp), and B lymphocyte stimulator…”
Get full text

The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes by Inoue, Ryota, Nishiyama, Kuniyuki, Li, Jinghe, Miyashita, Daisuke, Ono, Masato, Terauchi, Yasuo, Shirakawa, Jun

“…Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes…”
Get full text

Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes by Miyashita, Daisuke, Inoue, Ryota, Tsuno, Takahiro, Okuyama, Tomoko, Kyohara, Mayu, Nakahashi-Oda, Chigusa, Nishiyama, Kuniyuki, Fukushima, Setsuko, Inada, Yutaro, Togashi, Yu, Shibuya, Akira, Terauchi, Yasuo, Shirakawa, Jun

“…Obesity and diabetes are independent risk factors for death during sepsis. S100A8, an alarmin, is related to inflammation, obesity, and diabetes. Here, we…”
Get full text

Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER by Inoue, Ryota, Tsuno, Takahiro, Togashi, Yu, Okuyama, Tomoko, Sato, Aoi, Nishiyama, Kuniyuki, Kyohara, Mayu, Li, Jinghe, Fukushima, Setsuko, Kin, Tatsuya, Miyashita, Daisuke, Shiba, Yusuke, Atobe, Yoshitoshi, Kiyonari, Hiroshi, Bando, Kana, Shapiro, A.M. James, Funakoshi, Kengo, Kulkarni, Rohit N., Terauchi, Yasuo, Shirakawa, Jun

“…Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type 2 diabetes (T2DM); however, the…”
Get full text

The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1 by Kurihara, Yuji, Arie, Yuko, Iketani, Masumi, Ito, Hiromu, Nishiyama, Kuniyuki, Sato, Yasufumi, Nakamura, Fumio, Mizuki, Nobuhisa, Goshima, Yoshio, Takei, Kohtaro

“…► Two carboxyl-terminal regions of LOTUS bind to NgR1. ► The carboxyl-terminal regions of LOTUS block the binding of Nogo66 to NgR1. ► The carboxyl-terminal…”
Get full text

A Disproportionality Analysis of the Adverse Effect Profiles of Methimazole and Propylthiouracil in Patients with Hyperthyroidism Using the Japanese Adverse Drug Event Report Database by Arai, Masanori, Tsuno, Takahiro, Konishi, Hiromi, Nishiyama, Kuniyuki, Terauchi, Yasuo, Inoue, Ryota, Shirakawa, Jun

“…Antithyroid drugs (ATDs) are frequently used to achieve euthyroidism in patients with hyperthyroidism. ATDs cause characteristic common and rare adverse…”
Get more information

Vgll2 as an integrative regulator of mitochondrial function and contractility specific to skeletal muscle by Honda, Masahiko, Inoue, Ryota, Nishiyama, Kuniyuki, Ueda, Takeshi, Komuro, Akiyoshi, Amano, Hisayuki, Sugisawa, Ryoichi, Dash, Suman, Shirakawa, Jun, Okada, Hitoshi

“…During skeletal muscle adaptation to physiological or pathophysiological signals, contractile apparatus and mitochondrial function are coordinated to alter…”
Get full text

Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice by Nishiyama, Kuniyuki, Ono, Masato, Tsuno, Takahiro, Inoue, Ryota, Fukunaka, Ayako, Okuyama, Tomoko, Kyohara, Mayu, Togashi, Yu, Fukushima, Setsuko, Atsumi, Takuto, Sato, Aoi, Tsurumoto, Asuka, Sakai, Chisato, Fujitani, Yoshio, Terauchi, Yasuo, Ito, Shuichi, Shirakawa, Jun

“…Abstract Imeglimin and metformin act in metabolic organs, including β-cells, via different mechanisms. In the present study, we investigated the impacts of…”
Get full text

Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway by Li, Jinghe, Inoue, Ryota, Togashi, Yu, Okuyama, Tomoko, Satoh, Aoi, Kyohara, Mayu, Nishiyama, Kuniyuki, Tsuno, Takahiro, Miyashita, Daisuke, Kin, Tatsuya, Shapiro, A M James, Chew, Resilind Su Ern, Teo, Adrian Kee Keong, Oyadomari, Seiichi, Terauchi, Yasuo, Shirakawa, Jun

“…The effects of imeglimin, a novel antidiabetes agent, on β-cell function remain unclear. Here, we unveiled the impact of imeglimin on β-cell survival…”
Get full text

Protective Effects of Imeglimin and Metformin Combination Therapy on [beta]-Cells in db/db Male Mice by Nishiyama, Kuniyuki, Ono, Masato, Tsuno, Takahiro, Inoue, Ryota, Fukunaka, Ayako, Okuyama, Tomoko, Kyohara, Mayu, Togashi, Yu, Fukushima, Setsuko, Atsumi, Takuto, Sato, Aoi, Tsurumoto, Asuka, Sakai, Chisato, Fujitani, Yoshio, Terauchi, Yasuo, Ito, Shuichi, Shirakawa, Jun

“…Imeglimin and metformin act in metabolic organs, including [beta]-cells, via different mechanisms. In the present study, we investigated the impacts of…”
Get full text

Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca 2+ release from the ER by Inoue, Ryota, Tsuno, Takahiro, Togashi, Yu, Okuyama, Tomoko, Sato, Aoi, Nishiyama, Kuniyuki, Kyohara, Mayu, Li, Jinghe, Fukushima, Setsuko, Kin, Tatsuya, Miyashita, Daisuke, Shiba, Yusuke, Atobe, Yoshitoshi, Kiyonari, Hiroshi, Bando, Kana, Shapiro, A M James, Funakoshi, Kengo, Kulkarni, Rohit N, Terauchi, Yasuo, Shirakawa, Jun

“…Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type 2 diabetes (T2DM); however, the…”
Get full text

Antagonistic action of LOTUS, an endogenous antagonist of Nogo receptor, to B lymphocyte stimulator-induced axon growth inhibition by Nishiyama, Kuniyuki, Kurihara, Yuji, Iketani, Masumi, Itoh, Hiromu, Goshima, Yoshio, Takei, Kohtaro

Get full text

Physiological roles of LOTUS, an endogenous Nogo receptor antagonist, in lateral olfactory tract formation by Iketani, Masumi, Kurihara, Yuji, Sato, Yasufumi, Ito, Hiromu, Nishiyama, Kuniyuki, Goshima, Yoshio, Takei, Kohtaro

Get full text

Promotion of neurite outgrowth by an endogenous Nogo66 receptor antagonist LOTUS by Ito, Hiromu, Kurihara, Yuji, Iketani, Masumi, Nishiyama, Kuniyuki, Nakamura, Fumio, Goshima, Yoshio, Takei, Kohtaro

Get full text

Identification of a functional domain in endogenous Nogo66 receptor antagonist LOTUS by Kurihara, Yuji, Iketani, Masumi, Itoh, Hiromu, Nishiyama, Kuniyuki, Nakamura, Fumio, Mizuki, Nobuhisa, Goshima, Yoshio, Takei, Kohtaro

Get full text