Search Results - "Nishitani, Yasuhiro"

Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship by Aoki, Toshiaki, Yoshizawa, Hidenori, Yamawaki, Kenji, Yokoo, Katsuki, Sato, Jun, Hisakawa, Shinya, Hasegawa, Yasushi, Kusano, Hiroki, Sano, Masayuki, Sugimoto, Hideki, Nishitani, Yasuhiro, Sato, Takafumi, Tsuji, Masakatsu, Nakamura, Rio, Nishikawa, Toru, Yamano, Yoshinori

“…The structure-activity relationship (SAR) for a novel series of catechol conjugated siderophore cephalosporins is described with their in vitro activities…”
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Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B by Yoshida, Osamu, Yasukata, Tatsuro, Sumino, Yukihito, Munekage, Tadashi, Narukawa, Yukitoshi, Nishitani, Yasuhiro

“…A series of N-alkylated and aminomethylated derivatives of chloroorienticin B, a vancomycin-related glycopeptide antibiotic, were synthesized. Doubly-modified…”
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S-3578, a new broad spectrum parenteral cephalosporin exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Synthesis and structure-activity relationships by Yoshizawa, Hidenori, Itani, Hikaru, Ishikura, Koji, Irie, Tadashi, Yokoo, Katsuki, Kubota, Tadatoshi, Minami, Kyoji, Iwaki, Tsutomu, Miwa, Hideaki, Nishitani, Yasuhiro

“…A series of 7-aminothiadiazolylcephalosporins having a 1-(substituted)-1H-imidazo[4,5-b]pyridinium group at the C-3' position of the cephem nucleus were…”
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Synthesis and structure–activity relationships of a new class of 1-oxacephem-based human chymase inhibitors by Aoyama, Yasunori, Uenaka, Masaaki, Konoike, Toshiro, Iso, Yasuyoshi, Nishitani, Yasuhiro, Kanda, Akiko, Naya, Noriyuki, Nakajima, Masatoshi

“…1-Oxacephem derivatives were synthesized and evaluated as a novel series of chymase inhibitors. Structure–activity relationship studies of 1-oxacephems led to…”
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1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma by Aoyama, Yasunori, Uenaka, Masaaki, Konoike, Toshiro, Iso, Yasuyoshi, Nishitani, Yasuhiro, Kanda, Akiko, Naya, Noriyuki, Nakajima, Masatoshi

“…1-Oxacephem derivatives were evaluated as a novel series of chymase inhibitors. The structure–activity relationship studies of 1-oxacephems led to compounds…”
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Synthesis and modification of a novel 1 beta-methyl carbapenem antibiotic, S-4661 by Iso, Y, Irie, T, Iwaki, T, Kii, M, Sendo, Y, Motokawa, K, Nishitani, Y

“…We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl…”
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A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: Synthesis and structure–activity relationships by Yamawaki, Kenji, Nomura, Takashi, Yasukata, Tatsuro, Uotani, Koichi, Miwa, Hideaki, Takeda, Kei, Nishitani, Yasuhiro

“…A novel series of cephalosporins bearing a chlorominothiazole and a carboxymethoxyimino moiety at the C-7 side chain was prepared, and their antibacterial…”
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A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other Gram-negative pathogens. Part 2: Synthesis and structure–activity relationships by Yamawaki, Kenji, Nomura, Takashi, Yasukata, Tatsuro, Tanimoto, Norihiko, Uotani, Koichi, Miwa, Hideaki, Yamano, Yoshinori, Takeda, Kei, Nishitani, Yasuhiro

“…A novel series of 7β-[2-(2-amino-5-chloro-thiazol-4-yl)-2( Z)-(( S)-1-carboxyethoxyimino)acetamido]cephalosporins bearing various pyridinium groups at the C-3′…”
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New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 3: 7β-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3 by Yoshizawa, Hidenori, Kubota, Tadatoshi, Itani, Hikaru, Minami, Kyoji, Miwa, Hideaki, Nishitani, Yasuhiro

“…Graphic Among the prepared C-3′ substituted-pyridinium cephalosporins, a series of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins…”
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New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 2: Synthesis and structure–activity relationships in the S-3578 series by Yoshizawa, Hidenori, Kubota, Tadatoshi, Itani, Hikaru, Ishitobi, Hiroyuki, Miwa, Hideaki, Nishitani, Yasuhiro

“…Graphic Among the prepared novel cephalosporin derivatives related to S-3578, a series of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(…”
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New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 3: 7beta-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3 by Yoshizawa, Hidenori, Kubota, Tadatoshi, Itani, Hikaru, Minami, Kyoji, Miwa, Hideaki, Nishitani, Yasuhiro

“…Among the prepared C-3' substituted-pyridinium cephalosporins, a series of 7beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins…”
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A novel 1 beta-methylcarbapenem antibiotic, S-4661. Synthesis and structure-activity relationships of 2-(5-substituted pyrrolidin-3-ylthio)-1 beta-methylcarbapenems by Iso, Y, Irie, T, Nishino, Y, Motokawa, K, Nishitani, Y

“…The synthesis and biological activity of (1R,5S,6S)-2-[(3S,5S)-5-substituted pyrrolidin-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1- methylcarbapen-2-em-3-carboxylic…”
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An efficient and practical method for solid-phase synthesis of tripeptide-bearing glycopeptide antibiotics: combinatorial parallel synthesis of carboxamide derivatives of chloroorienticin B by Yasukata, Tatsuro, Shindo, Hirohisa, Yoshida, Osamu, Sumino, Yukihito, Munekage, Tadashi, Narukawa, Yukitoshi, Nishitani, Yasuhiro

“…An efficient and practical method was established for solid-phase parallel synthesis of the peptide-bearing carboxamide derivatives of chloroorienticin B, and…”
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Stereocontrolled Synthesis of 1b-Aminoalkylcarbapenems and Tricyclic Carbapenems (Trinems) by Iso, Yasuyoshi, Nishitani, Yasuhiro

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Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant s taphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B by Yoshida, Osamu, Yasukata, Tatsuro, Sumino, Yukihito, Munekage, Tadashi, Narukawa, Yukitoshi, Nishitani, Yasuhiro

“…A series of N-alkylated and aminomethylated derivatives of chloroorienticin B, a vancomycin-related glycopeptide antibiotic, were synthesized. Doubly-modified…”
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A New Method for Regioselective Synthesis of a Broad-Spectrum Parenteral S-3578-Related Cephalosporin Bearing an Imidazo[4,5-b]pyridinium Derivative at C-3 by Yoshizawa, Hidenori, Yokoo, Katsuki, Nomura, Takashi, Ohara, Takafumi, Ishikura, Koji, Nishitani, Yasuhiro

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Corrigendum to “synthesis and structure–activity relationships of a new class of 1-oxacephem-based human chymase inhibitors” [Bioorg. Med. Chem. Lett. 11 (2001) 2397] by Aoyama, Yasunori, Uenaka, Masaaki, Konoike, Toshiro, Iso, Yasuyoshi, Nishitani, Yasuhiro, Kanda, Akiko, Naya, Noriyuki, Nakajima, Masatoshi

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Synthesis of dihydrolycorine by Irie, H, Nishitani, Y, Sugita, M, Uyeo, S

“…Dihydrolycorine, which is the sole product from the hydrogenation of the alkaloid lycorine of the Amaryllidaceae, has now been synthesized by the following…”
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1,2,3,6-Tetrahydro-6-(3,4-dimethoxyphenyl)-phthalic Acidおよび関連化合物のFriedel-Crafts反応について by 入江, 寛, 西谷, 康宏, 杉田, 稔, 上尾, 庄次郎

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ジヒドロリコリンの合成 by 入江, 寛, 西谷, 康宏, 杉田, 稔, 上尾, 庄次郎

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