Search Results - "Nishimura, Emi K."

Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation by Nishimura, Emi K.

“…Summary Most mammals are coated with pigmented hair. Melanocytes in each hair follicle produce melanin pigments for the hair during each hair cycle. The key to…”
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Label‐free quality control and identification of human keratinocyte stem cells by deep learning‐based automated cell tracking by Hirose, Takuya, Kotoku, Jun'ichi, Toki, Fujio, Nishimura, Emi K., Nanba, Daisuke

“…Stem cell‐based products have clinical and industrial applications. Thus, there is a need to develop quality control methods to standardize stem cell…”
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Obesity accelerates hair thinning by stem cell-centric converging mechanisms by Morinaga, Hironobu, Mohri, Yasuaki, Grachtchouk, Marina, Asakawa, Kyosuke, Matsumura, Hiroyuki, Oshima, Motohiko, Takayama, Naoya, Kato, Tomoki, Nishimori, Yuriko, Sorimachi, Yuriko, Takubo, Keiyo, Suganami, Takayoshi, Iwama, Atsushi, Iwakura, Yoichiro, Dlugosz, Andrzej A., Nishimura, Emi K.

“…Obesity is a worldwide epidemic that predisposes individuals to many age-associated diseases, but its exact effects on organ dysfunction are largely unknown 1…”
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EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis by Nanba, Daisuke, Toki, Fujio, Asakawa, Kyosuke, Matsumura, Hiroyuki, Shiraishi, Ken, Sayama, Koji, Matsuzaki, Kyoichi, Toki, Hiroshi, Nishimura, Emi K

“…Skin regenerative capacity declines with age, but the underlying mechanisms are largely unknown. Here we demonstrate a functional link between epidermal growth…”
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p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress by Karigane, Daiki, Kobayashi, Hiroshi, Morikawa, Takayuki, Ootomo, Yukako, Sakai, Mashito, Nagamatsu, Go, Kubota, Yoshiaki, Goda, Nobuhito, Matsumoto, Michihiro, Nishimura, Emi K., Soga, Tomoyoshi, Otsu, Kinya, Suematsu, Makoto, Okamoto, Shinichiro, Suda, Toshio, Takubo, Keiyo

“…Hematopoietic stem cells (HSCs) maintain quiescence by activating specific metabolic pathways, including glycolysis. We do not yet have a clear understanding…”
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Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway by Fujino, Takeshi, Goyama, Susumu, Sugiura, Yuki, Inoue, Daichi, Asada, Shuhei, Yamasaki, Satoshi, Matsumoto, Akiko, Yamaguchi, Kiyoshi, Isobe, Yumiko, Tsuchiya, Akiho, Shikata, Shiori, Sato, Naru, Morinaga, Hironobu, Fukuyama, Tomofusa, Tanaka, Yosuke, Fukushima, Tsuyoshi, Takeda, Reina, Yamamoto, Keita, Honda, Hiroaki, Nishimura, Emi K., Furukawa, Yoichi, Shibata, Tatsuhiro, Abdel-Wahab, Omar, Suematsu, Makoto, Kitamura, Toshio

“…Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using…”
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A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease by Sun, Qi, Lee, Wendy, Mohri, Yasuaki, Takeo, Makoto, Lim, Chae Ho, Xu, Xiaowei, Myung, Peggy, Atit, Radhika P., Taketo, M. Mark, Moubarak, Rana S., Schober, Markus, Osman, Iman, Gay, Denise L., Saur, Dieter, Nishimura, Emi K., Ito, Mayumi

“…Melanoma, the deadliest skin cancer, remains largely incurable at advanced stages. Currently, there is a lack of animal models that resemble human melanoma…”
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Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche by Nishimura, Emi K., Cranter, Scott R., Fisher, David E.

“…Hair graying is the most obvious sign of aging in humans, yet its mechanism is largely unknown. Here, we used melanocyte-tagged transgenic mice and aging human…”
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Dynamic stem cell selection safeguards the genomic integrity of the epidermis by Kato, Tomoki, Liu, Nan, Morinaga, Hironobu, Asakawa, Kyosuke, Muraguchi, Taichi, Muroyama, Yuko, Shimokawa, Mariko, Matsumura, Hiroyuki, Nishimori, Yuriko, Tan, Li Jing, Hayano, Motoshi, Sinclair, David A., Mohri, Yasuaki, Nishimura, Emi K.

“…Maintaining genomic integrity and stability is crucial for life; yet, no tissue-driven mechanism that robustly safeguards the epithelial genome has been…”
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IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance by Muraguchi, Taichi, Nanba, Daisuke, Nishimura, Emi K., Tashiro, Tomoko

“…Epidermal stem cells (ESCs) are keratinocytes that reside in the basal layer of the epidermis and mediate epidermal homeostasis. Insulin-like growth factor 1…”
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Automated collective motion analysis validates human keratinocyte stem cell cultures by Kinoshita, Koji, Munesue, Takuya, Toki, Fujio, Isshiki, Masaharu, Higashiyama, Shigeki, Barrandon, Yann, Nishimura, Emi K., Yanagihara, Yoshio, Nanba, Daisuke

“…Identification and quality assurance of stem cells cultured in heterogeneous cell populations are indispensable for successful stem cell therapy. Here we…”
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Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning by Fisher, David E, D'Orazio, John A, Nobuhisa, Tetsuji, Cui, Rutao, Arya, Michelle, Spry, Malinda, Wakamatsu, Kazumasa, Igras, Vivien, Kunisada, Takahiro, Granter, Scott R, Nishimura, Emi K, Ito, Shosuke

“…Ultraviolet-light (UV)-induced tanning is defective in numerous 'fair-skinned' individuals, many of whom contain functional disruption of the melanocortin 1…”
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A melanocyte-melanoma precursor niche in sweat glands of volar skin by Okamoto, Natsuko, Aoto, Takahiro, Uhara, Hisashi, Yamazaki, Satoshi, Akutsu, Hidenori, Umezawa, Akihiro, Nakauchi, Hiromitsu, Miyachi, Yoshiki, Saida, Toshiaki, Nishimura, Emi K.

“…Summary Determination of the niche for early‐stage cancer remains a challenging issue. Melanoma is an aggressive cancer of the melanocyte lineage. Early…”
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Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability by Hiraoka, Chihiro, Toki, Fujio, Shiraishi, Ken, Sayama, Koji, Nishimura, Emi K, Miura, Hiromasa, Higashiyama, Shigeki, Nanba, Daisuke

“…Highlights • Human dermal fibroblasts were clonally expanded with hypoxic culture without chromosomal aberration. • Comprehensive phenotypic and gene…”
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Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF by Du, Jinyan, Widlund, Hans R., Horstmann, Martin A., Ramaswamy, Sridhar, Ross, Ken, Huber, Wade E., Nishimura, Emi K., Golub, Todd R., Fisher, David E.

“…The genomic organization of the CDK2 gene, which overlaps the melanocyte-specific gene SILV/PMEL17, poses an interesting regulatory challenge. We show that,…”
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NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP by Al-Busani, Hind, Al-Sobaihi, Saber, Nojima, Kohei, Tanemura, Atsushi, Yaguchi, Tomonori, Kawakami, Yutaka, Matsumura, Hiroyuki, Nishimura, Emi K., Yokozeki, Hiroo, Namiki, Takeshi

“…•A novel specific monoclonal antibody has been developed.•The distribution of NUAK2 expression in normal skin was characterized.•NUAK2 is expressed in various…”
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Dominant role of the niche in melanocyte stem-cell fate determination by Nishikawa, Shin-Ichi, Nishimura, Emi K, Jordan, Siobhán A, Oshima, Hideo, Yoshida, Hisahiro, Osawa, Masatake, Moriyama, Mariko, Jackson, Ian J, Barrandon, Yann, Miyachi, Yoshiki

“…Stem cells-which have the capacity to self-renew and generate differentiated progeny-are thought to be maintained in a specific environment known as a niche…”
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c-Met Expression Is Regulated by Mitf in the Melanocyte Lineage by McGill, Gaël G., Haq, Rizwan, Nishimura, Emi K., Fisher, David E.

“…Hepatocyte growth factor (HGF)/c-Met signaling is thought to be a key pathway in both melanocyte development and melanoma metastasis. Here, HGF stimulation of…”
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Evaluation of the proliferative potential of skin keratinocytes and fibroblasts isolated from critical limb ischemia patients by Toki, Fujio, Nanba, Daisuke, Nishimura, Emi K., Matsuzaki, Kyoichi

“…Impaired wound healing in critical limb ischemia (CLI) results from multiple factors that affect many cell types and their behavior. Epidermal keratinocytes…”
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Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles by Matsumura, Hiroyuki, Liu, Nan, Nanba, Daisuke, Ichinose, Shizuko, Takada, Aki, Kurata, Sotaro, Morinaga, Hironobu, Mohri, Yasuaki, De Arcangelis, Adèle, Ohno, Shigeo, Nishimura, Emi K

“…Hair follicles, mammalian mini-organs that grow hair, miniaturize during aging, leading to hair thinning and loss. Here we report that hair follicle stem cells…”
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