Search Results - "Nishimoto, Yoshinori"

NEAT1 lncRNA and amyotrophic lateral sclerosis by Nishimoto, Yoshinori, Nakagawa, Shinichi, Okano, Hideyuki

“…Amyotrophic lateral sclerosis (ALS) is a representative neurological disease that is known to devastate entire motor neurons within a period of just a few…”
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Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study by Sasaki, Takashi, Nishimoto, Yoshinori, Hirata, Takumi, Abe, Yukiko, Hirose, Nobuyoshi, Takayama, Michiyo, Takebayashi, Toru, Okano, Hideyuki, Arai, Yasumichi

“…Background: High levels of circulating adiponectin are associated with increased insulin sensitivity, low prevalence of diabetes, and low body mass index…”
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Characterization of Alternative Isoforms and Inclusion Body of the TAR DNA-binding Protein-43 by Nishimoto, Yoshinori, Ito, Daisuke, Yagi, Takuya, Nihei, Yoshihiro, Tsunoda, Yoshiko, Suzuki, Norihiro

“…TAR DNA-binding protein-43 (TDP-43) has been recently identified as a major component of the ubiquitinated inclusions found in frontotemporal lobar…”
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The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis by Nishimoto, Yoshinori, Nakagawa, Shinichi, Hirose, Tetsuro, Okano, Hirotaka James, Takao, Masaki, Shibata, Shinsuke, Suyama, Satoshi, Kuwako, Ken-Ichiro, Imai, Takao, Murayama, Shigeo, Suzuki, Norihiro, Okano, Hideyuki

“…A long non-coding RNA (lncRNA), nuclear-enriched abundant transcript 1_2 (NEAT1_2), constitutes nuclear bodies known as "paraspeckles". Mutations of RNA…”
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New insight into cancer therapeutics： Induction of differentiation by regulating the Musashi/Numb/Notch pathway by Nishimoto, Yoshinori, Okano, Hideyuki

“…The Musashi （Msi） family is a group of RNA-binding proteins characterized by two RNA recognition motifs （RRMs） and is evolutionarily conserved [1, 2]. In…”
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Characteristic features and progression of abnormalities on MRI for CARASIL by Nozaki, Hiroaki, Sekine, Yumi, Fukutake, Toshio, Nishimoto, Yoshinori, Shimoe, Yutaka, Shirata, Akiko, Yanagawa, Sohei, Hirayama, Mikio, Tamura, Masato, Nishizawa, Masatoyo, Onodera, Osamu

“…OBJECTIVES:The objective of this study was to clarify the characteristic brain MRI findings for genetically diagnosed CARASIL (cerebral autosomal recessive…”
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Impact of Amyloid and Tau PET on Changes in Diagnosis and Patient Management by Shimohama, Sho, Tezuka, Toshiki, Takahata, Keisuke, Bun, Shogyoku, Tabuchi, Hajime, Seki, Morinobu, Momota, Yuki, Suzuki, Natsumi, Morimoto, Ayaka, Iwabuchi, Yu, Kubota, Masahito, Yamamoto, Yasuharu, Sano, Yasunori, Shikimoto, Ryo, Funaki, Kei, Mimura, Yu, Nishimoto, Yoshinori, Ueda, Ryo, Jinzaki, Masahiro, Nakahara, Jin, Mimura, Masaru, Ito, Daisuke

“…Previous studies have evaluated the diagnostic effect of amyloid PET in selected research cohorts. However, these studies did not assess the clinical impact of…”
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Association between multimorbidity, self-rated health and life satisfaction among independent, community-dwelling very old persons in Japan: longitudinal cohort analysis from the Kawasaki Ageing and Well-being Project by Ando, Takayuki, Nishimoto, Yoshinori, Hirata, Takumi, Abe, Yukiko, Takayama, Midori, Maeno, Takashi, Fujishima, Seitaro, Takebayashi, Toru, Arai, Yasumichi

“…ObjectiveThis study aimed to identify associations between multimorbidity and subjective health outcomes among the very old persons, after adjusting for…”
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HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature by Uemura, Masahiro, Nozaki, Hiroaki, Kato, Taisuke, Koyama, Akihide, Sakai, Naoko, Ando, Shoichiro, Kanazawa, Masato, Hishikawa, Nozomi, Nishimoto, Yoshinori, Polavarapu, Kiran, Nalini, Atchayaram, Hanazono, Akira, Kuzume, Daisuke, Shindo, Akihiro, El-Ghanem, Mohammad, Abe, Arata, Sato, Aki, Yoshida, Mari, Ikeuchi, Takeshi, Mizuta, Ikuko, Mizuno, Toshiki, Onodera, Osamu

“…Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is clinically characterized by early-onset dementia,…”
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Determinants of polydoctoring among multimorbid older adults; a cross‐sectional study in an urban area of Japan by Ando, Takayuki, Sasaki, Takashi, Abe, Yukiko, Nishimoto, Yoshinori, Hirata, Takumi, Haruta, Junji, Arai, Yasumichi

“…Background Multimorbidity increases with age, leading to various adverse outcomes, including higher mortality, care dependency, hospitalizations, and…”
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Measurement of polydoctoring as a crucial component of fragmentation of care among patients with multimorbidity: Cross‐sectional study in Japan by Ando, Takayuki, Sasaki, Takashi, Abe, Yukiko, Nishimoto, Yoshinori, Hirata, Takumi, Haruta, Junji, Arai, Yasumichi

“…Background Care fragmentation, characterized by the uncoordinated involvement of multiple healthcare providers, leads to inefficient and ineffective…”
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RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways by Muto, Jun, Imai, Takao, Ogawa, Daisuke, Nishimoto, Yoshinori, Okada, Yohei, Mabuchi, Yo, Kawase, Takeshi, Iwanami, Akio, Mischel, Paul S, Saya, Hideyuki, Yoshida, Kazunari, Matsuzaki, Yumi, Okano, Hideyuki

“…Musashi1 (MSI1) is an RNA-binding protein that plays critical roles in nervous-system development and stem-cell self-renewal. Here, we examined its role in the…”
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Author reply to the definition and evaluation of uncoordinated involvement of multiple healthcare providers; “Polydoctoring” as a component of care fragmentation among patients with multimorbidity by Ando, Takayuki, Sasaki, Takashi, Abe, Yukiko, Nishimoto, Yoshinori, Hirata, Takumi, Haruta, Junji, Arai, Yasumichi

“…[...]objectively assessing the quality of coordination among various healthcare professionals remains a significant challenge in the current landscape. 3…”
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Association of polydoctoring and mortality among persons over 85 years with multimorbidity: a prospective cohort study in Japan by Ando, Takayuki, Sasaki, Takashi, Abe, Yukiko, Nishimoto, Yoshinori, Hirata, Takumi, Tajima, Takayuki, Oguma, Yuko, Haruta, Junji, Arai, Yasumichi

“…Polydoctoring can increase the risk of care fragmentation among patients with multimorbidity, but its impact on health outcomes remains unclear. To determine…”
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Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells by Ichiyanagi, Naoki, Fujimori, Koki, Yano, Masato, Ishihara-Fujisaki, Chikako, Sone, Takefumi, Akiyama, Tetsuya, Okada, Yohei, Akamatsu, Wado, Matsumoto, Takuya, Ishikawa, Mitsuru, Nishimoto, Yoshinori, Ishihara, Yasuharu, Sakuma, Tetsushi, Yamamoto, Takashi, Tsuiji, Hitomi, Suzuki, Naoki, Warita, Hitoshi, Aoki, Masashi, Okano, Hideyuki

“…Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disorder. Although its neuropathology is well understood, the cellular and molecular…”
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Cadherin-7 regulates mossy fiber connectivity in the cerebellum by Kuwako, Ken-Ichiro, Nishimoto, Yoshinori, Kawase, Satoshi, Okano, Hirotaka James, Okano, Hideyuki

“…To establish highly precise patterns of neural connectivity, developing axons must stop growing at their appropriate destinations and specifically synapse with…”
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Aging-related frailty and sarcopenia. Frailty and sarcopenia in the centenarians. by Nishimoto, Yoshinori, Arai, Yasumichi

“…The aging of society is coming up in Japan and it is one of the most important issues for us to prevent or reduce frailty and sarcopenia, two major causes of…”
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Determination of editors at the novel A-to-I editing positions by Nishimoto, Yoshinori, Yamashita, Takenari, Hideyama, Takuto, Tsuji, Shoji, Suzuki, Norihiro, Kwak, Shin

“…A-to-I RNA editing modifies a variety of biologically important mRNAs, and is specifically catalyzed by either adenosine deaminase acting on RNA type 1 (ADAR1)…”
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Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals by Matsuzawa, Yukimasa, Iwatsuki-Horimoto, Kiyoko, Nishimoto, Yoshinori, Abe, Yukiko, Fukuyama, Satoshi, Hamabata, Taiki, Okuda, Moe, Go, Yui, Watanabe, Tokiko, Imai, Masaki, Arai, Yasumichi, Fouchier, Ron A M, Yamayoshi, Seiya, Kawaoka, Yoshihiro

“…Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using…”
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RNA editing of the Q/R site of GluA2 in different cultured cell lines that constitutively express different levels of RNA editing enzyme ADAR2 by Yamashita, Takenari, Tadami, Chieko, Nishimoto, Yoshinori, Hideyama, Takuto, Kimura, Daisuke, Suzuki, Takeshi, Kwak, Shin

“…► ADAR2 catalyzes RNA editing at the Q/R site in the GluA2 pre-mRNA. ► The edited GluA2 pre-mRNA was more efficiently spliced than the unedited pre-mRNA. ► The…”
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