Search Results - "Nishikimi, Akihiko"

A senolytic immunotoxin eliminates p16INK4a-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse by Sugiyama, Yuma, Harada, Tanenobu, Kamei, Yuka, Yasuda, Tomoharu, Mashimo, Tomoji, Nishikimi, Akihiko, Maruyama, Mitsuo

“…Senescent cells were recently shown to play a role in aging-related malfunctions and pathologies. This consensus has been facilitated by evidence from…”
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Immune regulatory functions of DOCK family proteins in health and disease by Nishikimi, Akihiko, Kukimoto-Niino, Mutsuko, Yokoyama, Shigeyuki, Fukui, Yoshinori

“…DOCK proteins constitute a family of evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho family of GTPases. Although DOCK family…”
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Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking by Nishikimi, Akihiko, Ishihara, Sayaka, Ozawa, Madoka, Etoh, Kan, Fukuda, Mitsunori, Kinashi, Tatsuo, Katagiri, Koko

“…In lymphocytes, the kinase Mst1 is required for the proper organization of integrins in the plasma membrane at the leading edge of migrating cells, which is…”
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Use of heated tobacco products, moderate alcohol drinking, and anti-SARS-CoV-2 IgG antibody titers after BNT162b2 vaccination among Japanese healthcare workers by Yamamoto, Shohei, Tanaka, Akihito, Ohmagari, Norio, Yamaguchi, Koushi, Ishitsuka, Kazue, Morisaki, Naho, Kojima, Masayo, Nishikimi, Akihiko, Tokuda, Haruhiko, Inoue, Manami, Tanaka, Shiori, Umezawa, Jun, Okubo, Ryo, Nishimura, Kunihiro, Konishi, Maki, Miyo, Kengo, Mizoue, Tetsuya

“…The effect of heated tobacco products (HTPs) use and moderate alcohol drinking on immunogenicity to coronavirus disease (COVID-19) vaccines remain elusive…”
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Underlying medical conditions and anti-SARS-CoV-2 spike IgG antibody titers after two doses of BNT162b2 vaccination: A cross-sectional study by Li, Jiaqi, Nakagawa, Takeshi, Kojima, Masayo, Nishikimi, Akihiko, Tokuda, Haruhiko, Nishimura, Kunihiro, Umezawa, Jun, Tanaka, Shiori, Inoue, Manami, Ohmagari, Norio, Yamaguchi, Koushi, Takeda, Kazuyoshi, Yamamoto, Shohei, Konishi, Maki, Miyo, Kengo, Mizoue, Tetsuya

“…Patients with underlying medical conditions are at high risk of developing serious symptoms of the coronavirus disease 2019 than healthy individuals;…”
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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses by Harada, Yosuke, Tanaka, Yoshihiko, Terasawa, Masao, Pieczyk, Markus, Habiro, Katsuyoshi, Katakai, Tomoya, Hanawa-Suetsugu, Kyoko, Kukimoto-Niino, Mutsuko, Nishizaki, Tomoko, Shirouzu, Mikako, Duan, Xuefeng, Uruno, Takehito, Nishikimi, Akihiko, Sanematsu, Fumiyuki, Yokoyama, Shigeyuki, Stein, Jens V., Kinashi, Tatsuo, Fukui, Yoshinori

“…To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their shape to the given structure of the extracellular matrix and…”
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Underlying medical conditions and anti-SARS-CoV-2 spike IgG antibody titers after two doses of BNT162b2 vaccination: A cross-sectional study by Jiaqi Li, Takeshi Nakagawa, Masayo Kojima, Akihiko Nishikimi, Haruhiko Tokuda, Kunihiro Nishimura, Jun Umezawa, Shiori Tanaka, Manami Inoue, Norio Ohmagari, Koushi Yamaguchi, Kazuyoshi Takeda, Shohei Yamamoto, Maki Konishi, Kengo Miyo, Tetsuya Mizoue

“…Patients with underlying medical conditions are at high risk of developing serious symptoms of the coronavirus disease 2019 than healthy individuals;…”
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Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis by Nishikimi, Akihiko, Fukuhara, Hideo, Su, Wenjuan, Hongu, Tsunaki, Takasuga, Shunsuke, Mihara, Hisashi, Cao, Qinhong, Sanematsu, Fumiyuki, Kanai, Motomu, Hasegawa, Hiroshi, Tanaka, Yoshihiko, Shibasaki, Masakatsu, Kanaho, Yasunori, Sasaki, Takehiko, Frohman, Michael A, Fukui, Yoshinori

“…During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the…”
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The Cell Polarity Protein mInsc Regulates Neutrophil Chemotaxis via a Noncanonical G Protein Signaling Pathway by Kamakura, Sachiko, Nomura, Masatoshi, Hayase, Junya, Iwakiri, Yuko, Nishikimi, Akihiko, Takayanagi, Ryoichi, Fukui, Yoshinori, Sumimoto, Hideki

“…Successful chemotaxis requires not only increased motility but also sustained directionality. Here, we show that, during neutrophil chemotaxis via receptors…”
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DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation by Watanabe, Mayuki, Terasawa, Masao, Miyano, Kei, Yanagihara, Toyoshi, Uruno, Takehito, Sanematsu, Fumiyuki, Nishikimi, Akihiko, Côté, Jean-François, Sumimoto, Hideki, Fukui, Yoshinori

“…Neutrophils are highly motile leukocytes that play important roles in the innate immune response to invading pathogens. Neutrophils rapidly migrate to the site…”
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ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation by Uematsu, Keiji, Okumura, Fumihiko, Tonogai, Syunsuke, Joo-Okumura, Akiko, Alemayehu, Dawit Hailu, Nishikimi, Akihiko, Fukui, Yoshinori, Nakatsukasa, Kunio, Kamura, Takumi

“…Proper dynamic regulation of the spindle is essential for successful cell division. However, the molecular mechanisms that regulate spindle dynamics in mitosis…”
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The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells by Sugiyama, Yuma, Fujiwara, Mitsuhiro, Sakamoto, Akihiko, Tsushima, Hiromichi, Nishikimi, Akihiko, Maruyama, Mitsuo

“…Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses. We…”
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DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis by Kunisaki, Yuya, Nishikimi, Akihiko, Tanaka, Yoshihiko, Takii, Ryosuke, Noda, Mayuko, Inayoshi, Ayumi, Watanabe, Ken-ichi, Sanematsu, Fumiyuki, Sasazuki, Takehiko, Sasaki, Takehiko, Fukui, Yoshinori

“…Neutrophils are highly motile leukocytes, and they play important roles in the innate immune response to invading pathogens. Neutrophil chemotaxis requires Rac…”
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Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2 by Okumura, Fumihiko, Joo-Okumura, Akiko, Obara, Keisuke, Petersen, Alexander, Nishikimi, Akihiko, Fukui, Yoshinori, Nakatsukasa, Kunio, Kamura, Takumi

“…Eph receptor tyrosine kinases and their ephrin ligands are overexpressed in various human cancers, including colorectal malignancies, suggesting important…”
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The Rac Activator DOCK2 Mediates Plasma Cell Differentiation and IgG Antibody Production by Ushijima, Miho, Uruno, Takehito, Nishikimi, Akihiko, Sanematsu, Fumiyuki, Kamikaseda, Yasuhisa, Kunimura, Kazufumi, Sakata, Daiji, Okada, Takaharu, Fukui, Yoshinori

“…A hallmark of humoral immune responses is the production of antibodies. This process involves a complex cascade of molecular and cellular interactions,…”
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The Rac activator DOCK2 regulates natural killer cell–mediated cytotoxicity in mice through the lytic synapse formation by Sakai, Yusuke, Tanaka, Yoshihiko, Yanagihara, Toyoshi, Watanabe, Mayuki, Duan, Xuefeng, Terasawa, Masao, Nishikimi, Akihiko, Sanematsu, Fumiyuki, Fukui, Yoshinori

“…Natural killer (NK) cells play an important role in protective immunity against viral infection and tumor progression, but they also contribute to rejection of…”
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Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation by Gotoh, Kazuhito, Tanaka, Yoshihiko, Nishikimi, Akihiko, Nakamura, Risa, Yamada, Hisakata, Maeda, Naoyoshi, Ishikawa, Takahiro, Hoshino, Katsuaki, Uruno, Takehito, Cao, Qinhong, Higashi, Sadayuki, Kawaguchi, Yasushi, Enjoji, Munechika, Takayanagi, Ryoichi, Kaisho, Tsuneyasu, Yoshikai, Yasunobu, Fukui, Yoshinori

“…Plasmacytoid dendritic cells (pDCs) play a key role in antiviral immunity, but also contribute to the pathogenesis of certain autoimmune diseases, by producing…”
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Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms by Hanawa-Suetsugu, Kyoko, Kukimoto-Niino, Mutsuko, Mishima-Tsumagari, Chiemi, Akasaka, Ryogo, Ohsawa, Noboru, Sekine, Shun-ichi, Ito, Takuhiro, Tochio, Naoya, Koshiba, Seizo, Kigawa, Takanori, Terada, Takaho, Shirouzu, Mikako, Nishikimi, Akihiko, Uruno, Takehito, Katakai, Tomoya, Kinashi, Tatsuo, Kohda, Daisuke, Fukui, Yoshinori, Yokoyama, Shigeyuki

“…DOCK2, a hematopoietic cell-specific, atypical guanine nucleotide exchange factor, controls lymphocyte migration through ras-related C3 botulinum toxin…”
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Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration by Terasawa, Masao, Uruno, Takehito, Mori, Sayako, Kukimoto-Niino, Mutsuko, Nishikimi, Akihiko, Sanematsu, Fumiyuki, Tanaka, Yoshihiko, Yokoyama, Shigeyuki, Fukui, Yoshinori

“…The migratory properties of lymphocytes depend on DOCK2, an atypical Rac activator predominantly expressed in hematopoietic cells. Although DOCK2 does not…”
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Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding by Okumura, Fumihiko, Fujiki, Yuha, Oki, Nodoka, Osaki, Kana, Nishikimi, Akihiko, Fukui, Yoshinori, Nakatsukasa, Kunio, Kamura, Takumi

“…The UGA codon signals protein translation termination, but it can also be translated into selenocysteine (Sec, U) to produce selenocysteine-containing proteins…”
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