Search Results - "Nishikawa, Yuji"

Management of tumor growth and angiogenesis in triple-negative breast cancer by using redox nanoparticles by Shashni, Babita, Nishikawa, Yuji, Nagasaki, Yukio

“…In cancer, angiogenesis is a critical phenomenon of nascent blood vessel development to facilitate the oxygen and nutrient supply prerequisite for tumor…”
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Self-assembling polymer-based short chain fatty acid prodrugs ameliorate non-alcoholic steatohepatitis and liver fibrosis by Shashni, Babita, Tajika, Yuya, Ikeda, Yutaka, Nishikawa, Yuji, Nagasaki, Yukio

“…With the preponderance of a high-calorie diet and sedentary lifestyle, the prevalence of non-alcoholic steatohepatitis (NASH), a state of abnormally elevated…”
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Sorafenib-loaded silica-containing redox nanoparticles for oral anti-liver fibrosis therapy by Tran, Hao Thi, Vong, Long Binh, Nishikawa, Yuji, Nagasaki, Yukio

“…Liver fibrosis is a chronic disease resulting from repetitive or prolonged liver injury with limited treatment options. Sorafenib has been reported to be a…”
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Sry HMG Box Protein 9-positive (Sox9+) Epithelial Cell Adhesion Molecule-negative (EpCAM−) Biphenotypic Cells Derived from Hepatocytes Are Involved in Mouse Liver Regeneration by Tanimizu, Naoki, Nishikawa, Yuji, Ichinohe, Norihisa, Akiyama, Haruhiko, Mitaka, Toshihiro

“…It has been shown that mature hepatocytes compensate tissue damages not only by proliferation and/or hypertrophy but also by conversion into cholangiocyte-like…”
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Generation of combined hepatocellular‐cholangiocarcinoma through transdifferentiation and dedifferentiation in p53‐knockout mice by Liu, Yang, Xin, Bing, Yamamoto, Masahiro, Goto, Masanori, Ooshio, Takako, Kamikokura, Yuki, Tanaka, Hiroki, Meng, Lingtong, Okada, Yoko, Mizukami, Yusuke, Nishikawa, Yuji

“…The two principal histological types of primary liver cancers, hepatocellular carcinoma (HCC) and cholangiocarcinoma, can coexist within a tumor, comprising…”
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Targeting and Treatment of Tumor Hypoxia by Newly Designed Prodrug Possessing High Permeability in Solid Tumors by Ikeda, Yutaka, Hisano, Hikaru, Nishikawa, Yuji, Nagasaki, Yukio

“…Tumor hypoxia, which is associated with poor prognosis in cancer, is known to lead to resistance to radiotherapy and anticancer chemotherapy. Impaired drug…”
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Beneficial effects of end-ischemic oxygenated machine perfusion preservation for split-liver transplantation in recovering graft function and reducing ischemia–reperfusion injury by Ishii, Daisuke, Matsuno, Naoto, Gochi, Mikako, Iwata, Hiroyoshi, Shonaka, Tatsuya, Nishikawa, Yuji, Obara, Hiromichi, Yokoo, Hideki, Furukawa, Hiroyuki

“…This study examined the efficacy of end-ischemic hypothermic oxygenated machine perfusion preservation (HOPE) using an originally developed machine perfusion…”
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Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice by Chikada, Hiromi, Ida, Kinuyo, Nishikawa, Yuji, Inagaki, Yutaka, Kamiya, Akihide

“…The prevalence of non-alcoholic steatohepatitis (NASH) rapidly increases with metabolic disorders such as dyslipidaemia, high blood pressure, and…”
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Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice by Nishio, Miki, Sugimachi, Keishi, Goto, Hiroki, Wang, Jia, Morikawa, Takumi, Miyachi, Yosuke, Takano, Yusuke, Hikasa, Hiroki, Itoh, Tohru, Suzuki, Satoshi O., Kurihara, Hiroki, Aishima, Shinichi, Leask, Andrew, Sasaki, Takehiko, Nakano, Toru, Nishina, Hiroshi, Nishikawa, Yuji, Sekido, Yoshitaka, Nakao, Kazuwa, Shin-ya, Kazuo, Mimori, Koshi, Suzuki, Akira

“…Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b…”
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Poly(ornithine)-based self-assembling drug for recovery of hyperammonemia and damage in acute liver injury by Vong, Long B., Ibayashi, Yota, Lee, Yaroslav, Ngo, Dai-Nghiep, Nishikawa, Yuji, Nagasaki, Yukio

“…Oligo-peptides, including monomeric amino acids, have received much attention as bioactive molecules and drugs. One of the biggest problems of these compounds,…”
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Decreased Portal Circulation Augments Fibrosis and Ductular Reaction in Nonalcoholic Fatty Liver Disease in Mice by Meng, Lingtong, Goto, Masanori, Tanaka, Hiroki, Kamikokura, Yuki, Fujii, Yumiko, Okada, Yoko, Furukawa, Hiroyuki, Nishikawa, Yuji

“…Nonalcoholic fatty liver disease often progresses to cirrhosis and causes liver cancer, but mechanisms of its progression are yet to be elucidated. Although…”
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Generation of human iPSC-derived 3D bile duct within liver organoid by incorporating human iPSC-derived blood vessel by Carolina, Erica, Kuse, Yoshiki, Okumura, Ayumu, Aoshima, Kenji, Tadokoro, Tomomi, Matsumoto, Shinya, Kanai, Eriko, Okumura, Takashi, Kasai, Toshiharu, Yamabe, Souichiro, Nishikawa, Yuji, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Tanimizu, Naoki, Taniguchi, Hideki

“…In fetal development, tissue interaction such as the interplay between blood vessel (BV) and epithelial tissue is crucial for organogenesis. Here we…”
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Applicability of the histidine–tryptophan–ketoglutarate solution as a machine perfusion solution for marginal liver grafts by Iwata, Hiroyoshi, Matsuno, Naoto, Ishii, Daisuke, Toriumi, Asuka, Otani, Masahide, Ohara, Mizuho, Obara, Hiromichi, Nishikawa, Yuji, Yokoo, Hideki

“…Background and Aim There are very few reports comparing the use of the University of Wisconsin solution and histidine–tryptophan–ketoglutarate solution as…”
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Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands by Nakagawa, Hayato, Suzuki, Nobumi, Hirata, Yoshihiro, Hikiba, Yohko, Hayakawa, Yoku, Kinoshita, Hiroto, Ihara, Sozaburo, Uchino, Koji, Nishikawa, Yuji, Ijichi, Hideaki, Otsuka, Motoyuki, Arita, Junichi, Sakamoto, Yoshihiro, Hasegawa, Kiyoshi, Kokudo, Norihiro, Tateishi, Keisuke, Koike, Kazuhiko

“…The carcinogenic mechanism of extrahepatic cholangiocarcinoma (ECC) is unclear, due at least in part to the lack of an appropriate mouse model. Because human…”
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Successful Treatment of Nivolumab-related Cholangitis with Prednisolone: A Case Report and Review of the Literature by Sawada, Koji, Shonaka, Tatsuya, Nishikawa, Yuji, Hasegawa, Kimiharu, Hayashi, Hidemi, Hasebe, Takumu, Nakajima, Shunsuke, Ikuta, Katsuya, Fujiya, Mikihiro, Furukawa, Hiroyuki, Okumura, Toshikatsu

“…The patient was a 76-year-old man who was treated with nivolumab due to recurrent gastric cancer. A blood examination revealed grade 3 alkaline phosphatase…”
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Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non‐cirrhotic conditions by Chen, Xi, Yamamoto, Masahiro, Fujii, Kiyonaga, Nagahama, Yasuharu, Ooshio, Takako, Xin, Bing, Okada, Yoko, Furukawa, Hiroyuki, Nishikawa, Yuji

“…Hepatocellular carcinoma develops in either chronically injured or seemingly intact livers. To explore the tumorigenic mechanisms underlying these different…”
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Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis by Nakagawa, Hayato, Hikiba, Yohko, Hirata, Yoshihiro, Font-Burgada, Joan, Sakamoto, Kei, Hayakawa, Yoku, Taniguchi, Koji, Umemura, Atsushi, Kinoshita, Hiroto, Sakitani, Kosuke, Nishikawa, Yuji, Hirano, Kenji, Ikenoue, Tsuneo, Ijichi, Hideaki, Dhar, Debanjan, Shibata, Wataru, Akanuma, Masao, Koike, Kazuhiko, Karin, Michael, Maeda, Shin

“…E-cadherin is an important adhesion molecule whose loss is associated with progression and poor prognosis of liver cancer. However, it is unclear whether the…”
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Analysis of molecular interaction using a pulse-induced ring-down compression ATR-DIRLD step-scan time resolved spectroscopy/2D-IR by Nishikawa, Yuji, Ito, Hiroto, Noda, Isao

“…A rheo-optical method, based on pulsed compression ATR dynamic infrared linear dichroism (DIRLD) step scan time-resolved-FT-IR/2D-IR spectroscopy, is further…”
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Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors by Yamamoto, Masahiro, Xin, Bing, Watanabe, Kenji, Ooshio, Takako, Fujii, Kiyonaga, Chen, Xi, Okada, Yoko, Abe, Hiroaki, Taguchi, Yoshimitsu, Miyokawa, Naoyuki, Furukawa, Hiroyuki, Nishikawa, Yuji

“…Activation of the phosphoinositide 3-kinase–AKT, Yes-associated protein (YAP), and MYC pathways is involved in human liver cancers, including hepatocellular…”
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Progressive induction of hepatocyte progenitor cells in chronically injured liver by Tanimizu, Naoki, Ichinohe, Norihisa, Yamamoto, Masahiro, Akiyama, Haruhiko, Nishikawa, Yuji, Mitaka, Toshihiro

“…Differentiated epithelial cells show substantial lineage plasticity upon severe tissue injuries. In chronically injured mouse livers, part of hepatocytes…”
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