Search Results - "Nishikawa, Tomoko"
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Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size
Published in Biological & pharmaceutical bulletin (2017)“…Multicellular spheroids are useful as three-dimensional cell culture systems and for cell-based therapies. Their successful application requires an…”
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Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture
Published in Journal of bioscience and bioengineering (01-06-2015)“…During the production of therapeutic monoclonal antibodies (mAbs), not only enhancement of mAb productivity but also control of quality attributes is critical…”
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The effects of a life goal-setting technique in a preventive care program for frail community-dwelling older people: a cluster nonrandomized controlled trial
Published in BMC geriatrics (12-05-2016)“…Frailty among older people is associated with an increased risk of needing care. There have been many reports on preventive care programs for frail older…”
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Bacterial neuraminidase rescues influenza virus replication from inhibition by a neuraminidase inhibitor
Published in PloS one (18-09-2012)“…Influenza virus neuraminidase (NA) cleaves terminal sialic acid residues on oligosaccharide chains that are receptors for virus binding, thus playing an…”
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Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice
Published in Journal of controlled release (10-01-2014)“…The efficacy of cell-based therapy depends on the function and survival of transplanted cells, which have been suggested to be enhanced by spheroid formation…”
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Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids
Published in Pharmaceutical research (01-01-2016)“…Purpose We previously have shown that multicellular spheroids containing insulin-secreting cells are an effective therapy for diabetic mice. Here we attempted…”
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Using size‐controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice
Published in Biotechnology journal (01-08-2017)“…Previous studies demonstrated that multicellular spheroids developed using polydimethylsiloxane‐based microwells exhibited superior functions, such as insulin…”
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Dynamic Aspect of Reactive Oxygen and Nitric Oxide in Oral Cavity
Published in Journal of Clinical Biochemistry and Nutrition (01-01-2008)“…Oral mucosa is a critical protective interface between external and internal environments. Therefore, it must serve as a barrier to a huge number of microbial…”
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Effect of Nitric Oxide on the Oxygen Metabolism and Growth of E. faecalis
Published in Journal of Clinical Biochemistry and Nutrition (2009)“…Gastro-intestinal mucosal cells have a potent mechanism to eliminate a variety of pathogens using enzymes that generate reactive oxygen species and/or nitric…”
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Effect of Obstructive Jaundice and Nitric Oxide on the Profiles of Intestinal Bacterial Flora in Wild and iNOS−/− Mice
Published in Journal of Clinical Biochemistry and Nutrition (01-03-2009)“…We previously reported that the plasma level of endotoxin and colonic expression of IgA in the mouse increased with obstructive jaundice induced by bile duct…”
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Aplasia Cutis Congenita and Skull Defects after Exposure to Methimazole in Utero
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Potent primary leptomeningeal lymphoma masquerading as tuberculous meningitis - a case report
Published in Rinsho shinkeigaku = Clinical neurology (2012)“…A 45-year-old man presented with fever, progressive mutism and memory loss, was admitted to our hospital. MR imaging and angiography suggested multiple foci of…”
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Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids
Published in Journal of bioscience and bioengineering (01-06-2013)“…Microwell arrays that have many micro-sized cavities on the device have been employed to form multicellular spheroids. However, methods to efficiently harvest…”
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Improvement of Hypothyroidism after Glucocorticoid Replacement in Isolated Adrenocorticotropin Deficiency
Published in Internal Medicine (1995)“…We report a 50-year-old female who suffered from reversible hypothyroidism accompanied by isolated ACTH deficiency. There were no findings indicating a…”
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Prenatal Management of the Fetus with Lethal Malformation: From a Study of Oligohydramnios Sequence
Published in Fetal and pediatric pathology (01-03-2011)“…47 cases of oligohydramnios sequence (OS) diagnosed at Kanagawa Children's Medical Center from 1992 to 2008 were studied retrospectively. Early termination of…”
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An observer controller design method for 2-D discrete control systems
Published in 2015 IEEE International Conference on Information and Automation (01-08-2015)“…This work is concerned with the design of observer controllers for 2-d (2-dimensional) discrete control systems. The 2-d systems considered here correspond to…”
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Conference Proceeding -
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Design of asymptotically stabilizing state feedback controllers for 2-D discrete control systems
Published in 2015 IEEE International Conference on Information and Automation (01-08-2015)“…The paper is aimed to establish a feedback controller design procedure for a relatively general type of 2-D (2-dimensional) discrete control systems be…”
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Conference Proceeding -
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Living situation of the in-home patients suffering from amyotrophic lateral sclerosis in Aichi prefecture, Japan
Published in Rinsho shinkeigaku = Clinical neurology (2012)“…It is essential that we know the real situation of at-home patients with amyotrophic lateral sclerosis (ALS) in order to improve their medical support system…”
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