Search Results - "Nishihara, Reiko"

Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy by Nishihara, Reiko, Wu, Kana, Lochhead, Paul, Morikawa, Teppei, Liao, Xiaoyun, Qian, Zhi Rong, Inamura, Kentaro, Kim, Sun A, Kuchiba, Aya, Yamauchi, Mai, Imamura, Yu, Willett, Walter C, Rosner, Bernard A, Fuchs, Charles S, Giovannucci, Edward, Ogino, Shuji, Chan, Andrew T

“…Among 88,902 participants followed over a period of 22 years in the Nurses' Health Study and the Health Professionals Follow-up Study, colon cancer mortality…”
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Molecular pathological epidemiology: new developing frontiers of big data science to study etiologies and pathogenesis by Hamada, Tsuyoshi, Keum, NaNa, Nishihara, Reiko, Ogino, Shuji

“…Molecular pathological epidemiology (MPE) is an integrative field that utilizes molecular pathology to incorporate interpersonal heterogeneity of a disease…”
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Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication by LOCHHEAD, Paul, KUCHIBA, Aya, FUCHS, Charles S, OGINO, Shuji, IMAMURA, Yu, XIAOYUN LIAO, YAMAUCHI, Mai, NISHIHARA, Reiko, ZHI RONG QIAN, MORIKAWA, Teppei, SHEN, Jeanne, MEYERHARDT, Jeffrey A

“…BRAF mutation in colorectal cancer is associated with microsatellite instability (MSI) through its relationship with high-level CpG island methylator phenotype…”
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Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival by Liao, Xiaoyun, Lochhead, Paul, Nishihara, Reiko, Morikawa, Teppei, Kuchiba, Aya, Yamauchi, Mai, Imamura, Yu, Qian, Zhi Rong, Baba, Yoshifumi, Shima, Kaori, Sun, Ruifang, Nosho, Katsuhiko, Meyerhardt, Jeffrey A, Giovannucci, Edward, Fuchs, Charles S, Chan, Andrew T, Ogino, Shuji

“…In this study, mortality from colorectal cancer was reduced by about 80% in a subgroup of patients with tumors that expressed a mutated, activated form of…”
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Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum by Yamauchi, Mai, Morikawa, Teppei, Kuchiba, Aya, Imamura, Yu, Qian, Zhi Rong, Nishihara, Reiko, Liao, Xiaoyun, Waldron, Levi, Hoshida, Yujin, Huttenhower, Curtis, Chan, Andrew T, Giovannucci, Edward, Fuchs, Charles, Ogino, Shuji

“…Colorectal cancer is typically classified into proximal colon, distal colon and rectal cancer. Tumour genetic and epigenetic features differ by tumour…”
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Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma by Ning, Jian-Fang, Stanciu, Monica, Humphrey, Melissa R., Gorham, Joshua, Wakimoto, Hiroko, Nishihara, Reiko, Lees, Jacqueline, Zou, Lee, Martuza, Robert L., Wakimoto, Hiroaki, Rabkin, Samuel D.

“…PARP inhibitors (PARPis) have clinical efficacy in BRCA-deficient cancers, but not BRCA-intact tumors, including glioblastoma (GBM). We show that MYC or MYCN…”
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Genetic Mechanisms of Immune Evasion in Colorectal Cancer by Grasso, Catherine S, Giannakis, Marios, Wells, Daniel K, Hamada, Tsuyoshi, Mu, Xinmeng Jasmine, Quist, Michael, Nowak, Jonathan A, Nishihara, Reiko, Qian, Zhi Rong, Inamura, Kentaro, Morikawa, Teppei, Nosho, Katsuhiko, Abril-Rodriguez, Gabriel, Connolly, Charles, Escuin-Ordinas, Helena, Geybels, Milan S, Grady, William M, Hsu, Li, Hu-Lieskovan, Siwen, Huyghe, Jeroen R, Kim, Yeon Joo, Krystofinski, Paige, Leiserson, Mark D M, Montoya, Dennis J, Nadel, Brian B, Pellegrini, Matteo, Pritchard, Colin C, Puig-Saus, Cristina, Quist, Elleanor H, Raphael, Ben J, Salipante, Stephen J, Shin, Daniel Sanghoon, Shinbrot, Eve, Shirts, Brian, Shukla, Sachet, Stanford, Janet L, Sun, Wei, Tsoi, Jennifer, Upfill-Brown, Alexander, Wheeler, David A, Wu, Catherine J, Yu, Ming, Zaidi, Syed H, Zaretsky, Jesse M, Gabriel, Stacey B, Lander, Eric S, Garraway, Levi A, Hudson, Thomas J, Fuchs, Charles S, Ribas, Antoni, Ogino, Shuji, Peters, Ulrike

“…To understand the genetic drivers of immune recognition and evasion in colorectal cancer, we analyzed 1,211 colorectal cancer primary tumor samples, including…”
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Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors by Jeon, Jihyoun, Du, Mengmeng, Schoen, Robert E., Hoffmeister, Michael, Newcomb, Polly A., Berndt, Sonja I., Caan, Bette, Campbell, Peter T., Chan, Andrew T., Chang-Claude, Jenny, Giles, Graham G., Gong, Jian, Harrison, Tabitha A., Huyghe, Jeroen R., Jacobs, Eric J., Li, Li, Lin, Yi, Le Marchand, Loïc, Potter, John D., Qu, Conghui, Bien, Stephanie A., Zubair, Niha, Macinnis, Robert J., Buchanan, Daniel D., Hopper, John L., Cao, Yin, Nishihara, Reiko, Rennert, Gad, Slattery, Martha L., Thomas, Duncan C., Woods, Michael O., Prentice, Ross L., Gruber, Stephen B., Zheng, Yingye, Brenner, Hermann, Hayes, Richard B., White, Emily, Peters, Ulrike, Hsu, Li

“…Guidelines for initiating colorectal cancer (CRC) screening are based on family history but do not consider lifestyle, environmental, or genetic risk factors…”
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Dietary Patterns and Risk of Colorectal Cancer: Analysis by Tumor Location and Molecular Subtypes by Mehta, Raaj S, Song, Mingyang, Nishihara, Reiko, Drew, David A, Wu, Kana, Qian, Zhi Rong, Fung, Teresa T, Hamada, Tsuyoshi, Masugi, Yohei, da Silva, Annacarolina, Shi, Yan, Li, Wanwan, Gu, Mancang, Willett, Walter C, Fuchs, Charles S, Giovannucci, Edward L, Ogino, Shuji, Chan, Andrew T

“…Background & Aims Western and prudent dietary patterns have been associated with higher and lower risks of colorectal cancer (CRC), respectively. However,…”
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Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression by Lochhead, Paul, Chan, Andrew T, Nishihara, Reiko, Fuchs, Charles S, Beck, Andrew H, Giovannucci, Edward, Ogino, Shuji

“…The term ‘field effect' (also known as field defect, field cancerization, or field carcinogenesis) has been used to describe a field of cellular and molecular…”
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Population-wide Impact of Long-term Use of Aspirin and the Risk for Cancer by Cao, Yin, Nishihara, Reiko, Wu, Kana, Wang, Molin, Ogino, Shuji, Willett, Walter C, Spiegelman, Donna, Fuchs, Charles S, Giovannucci, Edward L, Chan, Andrew T

“…The US Preventive Services Task Force recently recommended the use of aspirin to prevent colorectal cancer and cardiovascular disease among many US adults…”
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Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review by XIAOYUN LIAO, MORIKAWA, Teppei, FUCHS, Charles S, OGINO, Shuji, LOCHHEAD, Paul, IMAMURA, Yu, KUCHIBA, Aya, YAMAUCHI, Mai, NOSHO, Katsuhiko, ZHI RONG QIAN, NISHIHARA, Reiko, MEYERHARDT, Jeffrey A

“…Mutations in PIK3CA [the gene encoding the p110α catalytic subunit of phosphatidylinositide-3-kinase (PI3K)] play an important role in colorectal…”
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Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma by Nakashima, Hiroshi, Nguyen, Tran, Kasai, Kazue, Passaro, Carmela, Ito, Hirotaka, Goins, William F, Shaikh, Imran, Erdelyi, Ronald, Nishihara, Reiko, Nakano, Ichiro, Reardon, David A, Anderson, Ana C, Kuchroo, Vijay, Chiocca, E Antonio

“…Glioblastoma (GBM) is the most common primary central nervous system cancer in adults. Oncolytic HSV-1 (oHSV) is the first FDA-approved gene therapy approach…”
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Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status by Hamada, Tsuyoshi, Cao, Yin, Qian, Zhi Rong, Masugi, Yohei, Nowak, Jonathan A, Yang, Juhong, Song, Mingyang, Mima, Kosuke, Kosumi, Keisuke, Liu, Li, Shi, Yan, da Silva, Annacarolina, Gu, Mancang, Li, Wanwan, Keum, NaNa, Zhang, Xuehong, Wu, Kana, Meyerhardt, Jeffrey A, Giovannucci, Edward L, Giannakis, Marios, Rodig, Scott J, Freeman, Gordon J, Nevo, Daniel, Wang, Molin, Chan, Andrew T, Fuchs, Charles S, Nishihara, Reiko, Ogino, Shuji

“…Purpose Blockade of the programmed cell death 1 (PDCD1, PD-1) immune checkpoint pathway can improve clinical outcomes in various malignancies. Evidence…”
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Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC by Keegan, Alissa, Ricciuti, Biagio, Garden, Padric, Cohen, Limor, Nishihara, Reiko, Adeni, Anika, Paweletz, Cloud, Supplee, Julianna, Jänne, Pasi A, Severgnini, Mariano, Awad, Mark M, Walt, David R

“…BackgroundBlood-based biomarkers of anti-solid tumor immune checkpoint blockade (ICB) response are lacking. We hypothesized that changes in systemic cytokine…”
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Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease by Ogino, Shuji, Lochhead, Paul, Chan, Andrew T, Nishihara, Reiko, Cho, Eunyoung, Wolpin, Brian M, Meyerhardt, Jeffrey A, Meissner, Alexander, Schernhammer, Eva S, Fuchs, Charles S, Giovannucci, Edward

“…Epigenetics acts as an interface between environmental/exogenous factors, cellular responses, and pathological processes. Aberrant epigenetic signatures are a…”
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Utility of inverse probability weighting in molecular pathological epidemiology by Liu, Li, Nevo, Daniel, Nishihara, Reiko, Cao, Yin, Song, Mingyang, Twombly, Tyler S., Chan, Andrew T., Giovannucci, Edward L., VanderWeele, Tyler J., Wang, Molin, Ogino, Shuji

“…As one of causal inference methodologies, the inverse probability weighting (IPW) method has been utilized to address confounding and account for missing data…”
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Aspirin Use and Risk of Colorectal Cancer According to BRAF Mutation Status by Nishihara, Reiko, Lochhead, Paul, Kuchiba, Aya, Jung, Seungyoun, Yamauchi, Mai, Liao, Xiaoyun, Imamura, Yu, Qian, Zhi Rong, Morikawa, Teppei, Wang, Molin, Spiegelman, Donna, Cho, Eunyoung, Giovannucci, Edward, Fuchs, Charles S, Chan, Andrew T, Ogino, Shuji

“…IMPORTANCE Aspirin use reduces the risk of colorectal carcinoma. Experimental evidence implicates a role of RAF kinases in up-regulation of…”
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Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin-Stained Sections by Väyrynen, Juha P, Lau, Mai Chan, Haruki, Koichiro, Väyrynen, Sara A, Dias Costa, Andressa, Borowsky, Jennifer, Zhao, Melissa, Fujiyoshi, Kenji, Arima, Kota, Twombly, Tyler S, Kishikawa, Junko, Gu, Simeng, Aminmozaffari, Saina, Shi, Shanshan, Baba, Yoshifumi, Akimoto, Naohiko, Ugai, Tomotaka, Da Silva, Annacarolina, Song, Mingyang, Wu, Kana, Chan, Andrew T, Nishihara, Reiko, Fuchs, Charles S, Meyerhardt, Jeffrey A, Giannakis, Marios, Ogino, Shuji, Nowak, Jonathan A

“…Although high T-cell density is a well-established favorable prognostic factor in colorectal cancer, the prognostic significance of tumor-associated plasma…”
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Prognostic Significance and Molecular Features of Signet-Ring Cell and Mucinous Components in Colorectal Carcinoma by Inamura, Kentaro, Yamauchi, Mai, Nishihara, Reiko, Kim, Sun A, Mima, Kosuke, Sukawa, Yasutaka, Li, Tingting, Yasunari, Mika, Zhang, Xuehong, Wu, Kana, Meyerhardt, Jeffrey A., Fuchs, Charles S., Harris, Curtis C., Qian, Zhi Rong, Ogino, Shuji

“…Background Colorectal carcinoma (CRC) represents a group of histopathologically and molecularly heterogeneous diseases, which may contain signet-ring cell…”
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