Search Results - "Nishigaya, Yosuke"

A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression by Takase, Shohei, Hiroyama, Takashi, Shirai, Fumiyuki, Maemoto, Yuki, Nakata, Akiko, Arata, Mayumi, Matsuoka, Seiji, Sonoda, Takeshi, Niwa, Hideaki, Sato, Shin, Umehara, Takashi, Shirouzu, Mikako, Nishigaya, Yosuke, Sumiya, Tatsunobu, Hashimoto, Noriaki, Namie, Ryosuke, Usui, Masaya, Ohishi, Tomokazu, Ohba, Shun-ichi, Kawada, Manabu, Hayashi, Yoshihiro, Harada, Hironori, Yamaguchi, Tokio, Shinkai, Yoichi, Nakamura, Yukio, Yoshida, Minoru, Ito, Akihiro

“…Sickle cell disease (SCD) is a heritable disorder caused by β-globin gene mutations. Induction of fetal γ-globin is an established therapeutic strategy…”
Get full text

Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents by Nishigaya, Yosuke, Takase, Shohei, Sumiya, Tatsunobu, Kikuzato, Ko, Sato, Tomohiro, Niwa, Hideaki, Sato, Shin, Nakata, Akiko, Sonoda, Takeshi, Hashimoto, Noriaki, Namie, Ryosuke, Honma, Teruki, Umehara, Takashi, Shirouzu, Mikako, Koyama, Hiroo, Yoshida, Minoru, Ito, Akihiro, Shirai, Fumiyuki

“…Identification of structurally novel inhibitors of lysine methyltransferase G9a has been a subject of intense research in cancer epigenetics. Starting with the…”
Get full text

Asymmetric Total Synthesis of (+)-Cytotrienin A, an Ansamycin-Type Anticancer Drug by Hayashi, Yujiro, Shoji, Mitsuru, Ishikawa, Hayato, Yamaguchi, Junichiro, Tamura, Tomohiro, Imai, Hiroki, Nishigaya, Yosuke, Takabe, Kenichi, Kakeya, Hideaki, Osada, Hiroyuki

“…A star‐studded lineup: (+)‐Cytotrienin A was the target of an asymmetric total synthesis featuring an enantioselective aldol reaction, α‐aminoxylation,…”
Get full text

Novel pyrazolo[1,5-a]pyridines as orally active EP1 receptor antagonists: Synthesis, structure-activity relationship studies, and biological evaluation by Umei, Kentaro, Nishigaya, Yosuke, Kondo, Atsushi, Tatani, Kazuya, Tanaka, Nobuyuki, Kohno, Yasushi, Seto, Shigeki

“…[Display omitted] Novel pyrazolo[1,5-a]pyridine derivatives were designed, synthesized and evaluated as orally active EP1 antagonists for the treatment of…”
Get full text

Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment by Nishigaya, Yosuke, Takase, Shohei, Sumiya, Tatsunobu, Sato, Tomohiro, Niwa, Hideaki, Sato, Shin, Nakata, Akiko, Matsuoka, Seiji, Maemoto, Yuki, Hashimoto, Noriaki, Namie, Ryosuke, Honma, Teruki, Umehara, Takashi, Shirouzu, Mikako, Koyama, Hiroo, Yoshida, Minoru, Ito, Akihiro, Shirai, Fumiyuki

“…[Display omitted] The discovery and development of structurally distinct lysine methyltransferase G9a inhibitors have been the subject of intense research in…”
Get full text

PBr3-mediated unexpected reductive deoxygenation of α-aryl-pyridinemethanols: synthesis of arylmethylpyridines by Nishigaya, Yosuke, Umei, Kentaro, Watanabe, Daisuke, Kohno, Yasushi, Seto, Shigeki

“…PBr3-mediated reductive deoxygenation of α-aryl-pyridinemethanols to provide arylmethylpyridines is described, the alcohol substrate scope is explored, free…”
Get full text

PBr sub(3)-mediated unexpected reductive deoxygenation of alpha -aryl-pyridinemethanols: synthesis of arylmethylpyridines by Nishigaya, Yosuke, Umei, Kentaro, Watanabe, Daisuke, Kohno, Yasushi, Seto, Shigeki

“…PBr sub(3)-mediated reductive deoxygenation of alpha -aryl-pyridinemethanols to provide arylmethylpyridines is described, the alcohol substrate scope is…”
Get full text

Direct access to 2-aminopyrazolo[1,5-a]pyridines via N-amination/cyclization reactions of 2-pyridineacetonitriles by Nishigaya, Yosuke, Umei, Kentaro, Yamamoto, Eri, Kohno, Yasushi, Seto, Shigeki

“…We describe the straightforward synthesis of 6-substituted-2-aminopyrazolo[1,5-a]pyridines from 2-pyridineacetonitriles by N-amination with…”
Get full text

Identification of novel 1,2,3,6-tetrahydropyridyl-substituted benzo[d]thiazoles: Lead generation and optimization toward potent and orally active EP1 receptor antagonists by Umei, Kentaro, Nishigaya, Yosuke, Tatani, Kazuya, Kohno, Yasushi, Tanaka, Nobuyuki, Seto, Shigeki

“…[Display omitted] Herein we described the design, synthesis and evaluation of a novel series of benzo[d]thiazole derivatives toward an orally active EP1…”
Get full text

Discovery of novel pyrazolo[1,5-a]pyridine-based EP1 receptor antagonists by scaffold hopping: Design, synthesis, and structure-activity relationships by Nishigaya, Yosuke, Umei, Kentaro, Saito, Yoshifumi, Watanabe, Hiroyuki, Kondo, Tatsuhiro, Kondo, Atsushi, Kawamura, Naohiro, Tatani, Kazuya, Kohno, Yasushi, Tanaka, Nobuyuki, Seto, Shigeki

“…[Display omitted] A scaffold-hopping strategy towards a new pyrazolo[1,5-a]pyridine based core using molecular hybridization of two structurally distinct EP1…”
Get full text

Identification of novel 1,2,3,6-tetrahydropyridyl-substituted benzo[d]thiazoles: Lead generation and optimization toward potent and orally active EP 1 receptor antagonists by Umei, Kentaro, Nishigaya, Yosuke, Tatani, Kazuya, Kohno, Yasushi, Tanaka, Nobuyuki, Seto, Shigeki

“…Herein we described the design, synthesis and evaluation of a novel series of benzo[d]thiazole derivatives toward an orally active EP antagonist. Lead…”
Get full text

Novel pyrazolo[1,5-a]pyridines as orally active EP 1 receptor antagonists: Synthesis, structure-activity relationship studies, and biological evaluation by Umei, Kentaro, Nishigaya, Yosuke, Kondo, Atsushi, Tatani, Kazuya, Tanaka, Nobuyuki, Kohno, Yasushi, Seto, Shigeki

“…Novel pyrazolo[1,5-a]pyridine derivatives were designed, synthesized and evaluated as orally active EP antagonists for the treatment of overactive bladder…”
Get full text

Discovery of novel pyrazolo[1,5-a]pyridine-based EP 1 receptor antagonists by scaffold hopping: Design, synthesis, and structure-activity relationships by Nishigaya, Yosuke, Umei, Kentaro, Saito, Yoshifumi, Watanabe, Hiroyuki, Kondo, Tatsuhiro, Kondo, Atsushi, Kawamura, Naohiro, Tatani, Kazuya, Kohno, Yasushi, Tanaka, Nobuyuki, Seto, Shigeki

“…A scaffold-hopping strategy towards a new pyrazolo[1,5-a]pyridine based core using molecular hybridization of two structurally distinct EP antagonists,…”
Get full text

The Asymmetric Total Synthesis of (+)-Cytotrienin A, an Ansamycin-Type Anticancer Drug by Hayashi, Yujiro, Shoji, Mitsuru, Ishikawa, Hayato, Yamaguchi, Junichiro, Tamura, Tomohiro, Imai, Hiroki, Nishigaya, Yosuke, Takabe, Kenichi, Kakeya, Hideaki, Osada, Hiroyuki

“…Alle Stereozentren korrekt: (+)‐Cytotrienin A wurde durch enantioselektive Aldolreaktion, α‐Aminoxylierung, Desoxygenierung und Ringschlussmetathese erhalten…”
Get full text

The Asymmetric Total Synthesis of (+)‐Cytotrienin A, an Ansamycin‐Type Anticancer Drug by Hayashi, Yujiro, Shoji, Mitsuru, Ishikawa, Hayato, Yamaguchi, Junichiro, Tamura, Tomohiro, Imai, Hiroki, Nishigaya, Yosuke, Takabe, Kenichi, Kakeya, Hideaki, Osada, Hiroyuki

Get full text