Search Results - "Nishida, Eisuke"

Dual role of YAP and TAZ in renewal of the intestinal epithelium by Imajo, Masamichi, Ebisuya, Miki, Nishida, Eisuke

“…The rapidly self-renewing intestinal epithelium represents an exquisite model for stem cell biology. So far, genetic studies in mice have uncovered crucial…”
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HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer by Ordóñez-Morán, Paloma, Dafflon, Caroline, Imajo, Masamichi, Nishida, Eisuke, Huelsken, Joerg

“…Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation…”
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Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone by Miyata, Yoshihiko, Nishida, Eisuke

“…The DYRK (Dual-specificity tYrosine-phosphorylation Regulated protein Kinase) family consists of five related protein kinases (DYRK1A, DYRK1B, DYRK2, DYRK3,…”
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Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner by Toyoshima, Fumiko, Nishida, Eisuke

“…The orientation of mitotic spindles is tightly regulated in polarized cells, but it has been unclear whether there is a mechanism regulating spindle…”
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Regulation of MAP kinases by MAP kinase phosphatases by Kondoh, Kunio, Nishida, Eisuke

“…MAP kinase phosphatases (MKPs) catalyze dephosphorylation of activated MAP kinase (MAPK) molecules and deactivate them. Therefore, MKPs play an important role…”
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Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans by Kishimoto, Saya, Uno, Masaharu, Okabe, Emiko, Nono, Masanori, Nishida, Eisuke

“…Hormesis is a biological phenomenon, whereby exposure to low levels of toxic agents or conditions increases organismal viability. It thus represents a…”
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The microRNA machinery regulates fasting-induced changes in gene expression and longevity in Caenorhabditis elegans by Kogure, Akiko, Uno, Masaharu, Ikeda, Takako, Nishida, Eisuke

“…Intermittent fasting (IF) is a dietary restriction regimen that extends the lifespans of Caenorhabditis elegans and mammals by inducing changes in gene…”
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Lactobacillus paracasei subsp. paracasei 2004 improves health and lifespan in Caenorhabditis elegans by Kishimoto, Saya, Nono, Masanori, Makizaki, Yutaka, Tanaka, Yoshiki, Ohno, Hiroshi, Nishida, Eisuke, Uno, Masaharu

“…Recent research has highlighted the importance of the gut microbiome in regulating aging, and probiotics are interventions that can promote gut health. In this…”
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ERK MAP kinase in G1 cell cycle progression and cancer by Torii, Satoru, Yamamoto, Takuya, Tsuchiya, Yoshiki, Nishida, Eisuke

“…The extracellular‐signal‐regulated kinase (ERK) mitogen‐activated protein (MAP) kinase signaling pathway plays an important role in various cellular responses,…”
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The Sexual Dimorphism of Dietary Restriction Responsiveness in Caenorhabditis elegans by Honjoh, Sakiko, Ihara, Akiko, Kajiwara, Yukiko, Yamamoto, Takuya, Nishida, Eisuke

“…Organismal lifespan is highly plastic in response to environmental cues, and dietary restriction (DR) is the most robust way to extend lifespan in various…”
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The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity by Ebisuya, Miki, Kondoh, Kunio, Nishida, Eisuke

“…ERK MAP kinase signaling plays a pivotal role in diverse cellular functions, including cell proliferation, differentiation, migration and survival. One of the…”
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The Molecular Chaperone TRiC/CCT Binds to the Trp-Asp 40 (WD40) Repeat Protein WDR68 and Promotes Its Folding, Protein Kinase DYRK1A Binding, and Nuclear Accumulation by Miyata, Yoshihiko, Shibata, Takeshi, Aoshima, Masato, Tsubata, Takuichi, Nishida, Eisuke

“…Trp-Asp (WD) repeat protein 68 (WDR68) is an evolutionarily conserved WD40 repeat protein that binds to several proteins, including dual specificity tyrosine…”
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Foxd1 is a mediator and indicator of the cell reprogramming process by Koga, Makito, Matsuda, Mitsuhiro, Kawamura, Teruhisa, Sogo, Takahiro, Shigeno, Asako, Nishida, Eisuke, Ebisuya, Miki

“…It remains unclear how changes in gene expression profiles that establish a pluripotent state are induced during cell reprogramming. Here we identify two…”
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The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture by Takahashi, Chika, Miyatake, Koichi, Kusakabe, Morioh, Nishida, Eisuke

“…Epithelia contribute to physical barriers that protect internal tissues from the external environment and also support organ structure. Accordingly,…”
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Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans by Nono, Masanori, Kishimoto, Saya, Sato-Carlton, Aya, Carlton, Peter Mark, Nishida, Eisuke, Uno, Masaharu

“…Changes in epigenetic states affect organismal homeostasis, including stress resistance. However, the mechanisms coordinating epigenetic states and systemic…”
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Continuous ERK Activation Downregulates Antiproliferative Genes throughout G1 Phase to Allow Cell-Cycle Progression by Yamamoto, Takuya, Ebisuya, Miki, Ashida, Fumito, Okamoto, Kazuo, Yonehara, Shin, Nishida, Eisuke

“…The ERK family of MAP kinase plays a critical role in growth factor-stimulated cell-cycle progression from G0/G1 to S phase. It has been suggested that…”
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Octopamine enhances oxidative stress resistance through the fasting‐responsive transcription factor DAF‐16/FOXO in C. elegans by Hoshikawa, Haruka, Uno, Masaharu, Honjoh, Sakiko, Nishida, Eisuke

“…Dietary restriction regimens lead to enhanced stress resistance and extended life span in many species through the regulation of fasting and/or diet‐responsive…”
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Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis by Adachi, Makoto, Kawasaki, Asami, Nojima, Hisashi, Nishida, Eisuke, Tsukita, Sachiko

“…IQGAP family proteins, comprising IQGAP1, ‐2, and ‐3 in mammals, are involved in diverse ranges of cellular processes such as adhesion and migration. IQGAP…”
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Noninvasive method for assessing the human circadian clock using hair follicle cells by Akashi, Makoto, Soma, Haruhiko, Yamamoto, Takuro, Tsugitomi, Asuka, Yamashita, Shiko, Yamamoto, Takuya, Nishida, Eisuke, Yasuda, Akio, Liao, James K., Node, Koichi, Takahashi, Joseph S.

“…A thorough understanding of the circadian clock requires qualitative evaluation of circadian clock gene expression. Thus far, no simple and effective method…”
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FGF induces oscillations of Hes1 expression and Ras/ERK activation by Nakayama, Kei, Satoh, Takayuki, Igari, Aiko, Kageyama, Ryoichiro, Nishida, Eisuke

“…Many biological processes, such as circadian rhythms and somite segmentation [1], are regulated by molecular clocks. During somitogenesis, mRNAs for Notch…”
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