Search Results - "Nishi, Saki"

Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage by Malchow, Sven, Leventhal, Daniel S., Lee, Victoria, Nishi, Saki, Socci, Nicholas D., Savage, Peter A.

“…The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by autoimmune regulator (Aire), is critical for the protection of…”
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Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells by Malchow, Sven, Leventhal, Daniel S., Nishi, Saki, Fischer, Benjamin I., Shen, Lynn, Paner, Gladell P., Amit, Ayelet S., Kang, Chulho, Geddes, Jenna E., Allison, James P., Socci, Nicholas D., Savage, Peter A.

“…Despite considerable interest in the modulation of tumor-associated Foxp3 + regulatory T cells (T regs ) for therapeutic benefit, little is known about the…”
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PD‐1 regulates extrathymic regulatory T‐cell differentiation by Chen, Xiufen, Fosco, Dominick, Kline, Douglas E., Meng, Liping, Nishi, Saki, Savage, Peter A., Kline, Justin

“…Treg cells and the programed death‐1/programed death ligand‐1 (PD‐1/PD‐L1) pathway are both critical for maintaining peripheral tolerance to self‐Ags. A…”
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Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells by Leventhal, Daniel S., Gilmore, Dana C., Berger, Julian M., Nishi, Saki, Lee, Victoria, Malchow, Sven, Kline, Douglas E., Kline, Justin, Vander Griend, Donald J., Huang, Haochu, Socci, Nicholas D., Savage, Peter A.

“…Although antigen recognition mediated by the T cell receptor (TCR) influences many facets of Foxp3+ regulatory T (Treg) cell biology, including development and…”
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Identification and functional characterization of the antigen presenting cells recognized by tumor-associated regulatory T cells in genetically engineered mouse models of prostate cancer (P5065) by Shen, Lynn, Nishi, Saki, Savage, Peter

“…Abstract The enrichment of Foxp3+ regulatory T cells (Tregs) constitutes a central mechanism of immune regulation, but has also been associated with poor…”
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Dendritic cells coordinate the development and homeostasis of organ-specific regulatory T cells (LYM2P.730) by Leventhal, Daniel, Nishi, Saki, Gilmore, Dana, Malchow, Sven, Kline, Douglas, Kline, Justin, Savage, Peter

“…Abstract Foxp3+ regulatory T cells (Tregs) are critical for the maintenance of tolerance to self. However, the antigen presenting cells (APCs) controlling the…”
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Autoimmune Regulator (Aire) is critical for the thymic development of naturally occurring Treg specificities (P1185) by Leventhal, Daniel, Malchow, Sven, Nishi, Saki, Fischer, Benjamin, Paner, Gladell, Savage, Peter

“…Abstract While the transcription factor Autoimmune Regulator (AIRE) has been shown to play a critical role in establishing immune tolerance through the…”
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Murine prostate tumors recruit and expand thymic-derived regulatory T cell populations (P2191) by Malchow, Sven, Leventhal, Daniel, Nishi, Saki, Fischer, Benjamin, Socci, Nicholas, Savage, Peter

“…Abstract For some human cancers, elevated densities of Foxp3+ regulatory T cells (Tregs) in the tumor tissue correlate with poor prognosis, suggesting that…”
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