Search Results - "Nishanth, J."

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes by Skinnider, Michael A, Merwin, Nishanth J, Johnston, Chad W, Magarvey, Nathan A

“…Microbial natural products represent a rich resource of pharmaceutically and industrially important compounds. Genome sequencing has revealed that the majority…”
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Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences by Skinnider, Michael A., Johnston, Chad W., Gunabalasingam, Mathusan, Merwin, Nishanth J., Kieliszek, Agata M., MacLellan, Robyn J., Li, Haoxin, Ranieri, Michael R. M., Webster, Andrew L. H., Cao, My P. T., Pfeifle, Annabelle, Spencer, Norman, To, Q. Huy, Wallace, Dan Peter, Dejong, Chris A., Magarvey, Nathan A.

“…Novel antibiotics are urgently needed to address the looming global crisis of antibiotic resistance. Historically, the primary source of clinically used…”
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DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products by Merwin, Nishanth J., Mousa, Walaa K., Dejong, Chris A., Skinnider, Michael A., Cannon, Michael J., Li, Haoxin, Dial, Keshav, Gunabalasingam, Mathusan, Johnston, Chad, Magarvey, Nathan A.

“…Microbial natural products represent a rich resource of evolved chemistry that forms the basis for the majority of pharmacotherapeutics. Ribosomally…”
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Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining by Skinnider, Michael A., Johnston, Chad W., Edgar, Robyn E., Dejong, Chris A., Merwin, Nishanth J., Rees, Philip N., Magarvey, Nathan A.

“…Microbial natural products are an evolved resource of bioactive small molecules, which form the foundation of many modern therapeutic regimes. Ribosomally…”
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Antibiotics and specialized metabolites from the human microbiota by Mousa, Walaa K, Athar, Bilal, Merwin, Nishanth J, Magarvey, Nathan A

“…Covering: 2000 to 2017Decades of research on human microbiota have revealed much of their taxonomic diversity and established their direct link to health and…”
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Understanding the neural basis of survival instinct vs. suicidal behavior: a key to decode the biological enigma of human suicidal behavior by Nishanth, M. J., Jha, Shanker

“…Suicidal behavior is a globally widespread psychiatric disorder with a high rate of mortality. Suicide causes psychological and economic hardships for the…”
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Computational analysis of crosstalk between transcriptional regulators and RNA-binding proteins suggests mutual regulation of polycomb proteins and SRSF1 influencing adult hippocampal neurogenesis by Nishanth, M. J., Jha, Shanker

“…Background Adult hippocampal neurogenesis (AHN) is a clinically significant neural phenomenon. Understanding its molecular regulation would be important. In…”
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Genome-wide landscape of RNA-binding protein networks as potential molecular regulators of psychiatric co-morbidities: a computational analysis by Nishanth, M. J, Jha, Shanker

“…Background Psychiatric disorders are a major burden on global health. These illnesses manifest as co-morbid conditions, further complicating the treatment…”
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Global Exploration of RNA-Binding Proteins in Exercise-Induced Adult Hippocampal Neurogenesis: A Transcriptome Meta-analysis and Computational Study by Nishanth, M. J., Jha, Shanker

“…Voluntary physical exercise is a robust enhancer of adult hippocampal neurogenesis (AHN). A complete understanding of the molecular regulation of AHN is…”
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Hybrid energy harvesting by reverse di-electric on a piezo-electric generator with thermo-couple and monitoring in WSN by Nishanth, J.R., Senthilkumar, B.

“…Smart renewable energy harvesting has been implemented from hybrid sources such as solar and wind. The wireless sensor node is created for monitoring surface…”
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Computational analysis of the divergent neurotranscriptomic signatures of major depression and suicidality by Nishanth, M. J, Karthick, S. Sai, Jha, Shanker

“…Background Suicide is a leading cause of death globally. Identifying individuals at higher suicidal risk is a key to suicide prevention. Patients with comorbid…”
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Stress-Mediated cis -Element Transcription Factor Interactions Interconnecting Primary and Specialized Metabolism in planta by Sheshadri, S A, Nishanth, M J, Simon, Bindu

“…Plant specialized metabolites are being used worldwide as therapeutic agents against several diseases. Since the precursors for specialized metabolites come…”
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Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis by Skinnider, Michael A, Johnston, Chad W, Merwin, Nishanth J, Dejong, Chris A, Magarvey, Nathan A

“…Among naturally occurring small molecules, tRNA-derived cyclodipeptides are a class that have attracted attention for their diverse and desirable biological…”
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Diagnostic Prevalence of Common Psychiatric Comorbidities of Alcohol Use Disorders in India: a Systematic Review by Hendrickson, Rebecca, Nishanth, J. H., Michael, Scott

“…The diagnostic prevalence of mood and anxiety disorders in Indian individuals with alcohol use disorders (AUDs) has important implications for clinical…”
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Expression analysis of Cell wall invertase under abiotic stress conditions influencing specialized metabolism in Catharanthus roseus by Nishanth, M. J., Sheshadri, S. A., Rathore, Sudarshan Singh, Srinidhi, S., Simon, Bindu

“…Catharanthus roseus is a commercial source for anti-cancer terpenoid indole alkaloids (TIAs: vincristine and vinblastine). Inherent levels of these TIAs are…”
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Productive and reproductive performance of cattle in the tropical part of India by C, SUMI PRINCESS, KUMAR, DINESH, SARAN, SANDEEP, KUMAR, SANJAY, SHARMA, RUCHI, JUNIWAL, CHITRA, P, THAMIZHAN, NISHANTH J, MARIA ANTO DANI, D, DINESH

“…The assessment of productive and reproductive traits helps in identifying animals with superior germplasm in comparison to their population mean which helps in…”
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Analysis of the Functional Outcome of Arthroscopic Anterior Cruciate Ligament Reconstruction Using the Central Quadriceps Tendon Graft by Parameshwar, Ambareesh, Kumar, Lanka Bhupati, Donthi, Supreeth R, Gurucharan, S, Reddy, Nishanth J, Gbs, Varun, M S, Vishwanath, Gurudatta, Amruta, Shahid, Mohammed

“…Anterior cruciate ligament (ACL) injuries are common, particularly among athletes, and often result in knee instability and decreased functionality…”
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Transcriptome meta-analysis-based identification of hub transcription factors and RNA-binding proteins potentially orchestrating gene regulatory cascades and crosstalk in response to abiotic stresses in Arabidopsis thaliana by Nishanth, M. J.

“…Deteriorating climatic conditions and increasing human population necessitate the development of robust plant varieties resistant to harsh environments…”
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Functions, mechanisms and regulation of Pumilio/Puf family RNA binding proteins: a comprehensive review by Nishanth, M. J., Simon, Bindu

“…The Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes, including yeast, plants and humans. They generally bind to the 3′…”
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Evolutionary Analysis of the hnRNP Interactomes and Their Functions in Eukaryotes by Nishanth, M. J., Jha, Shanker

“…The heterogeneous nuclear ribonucleoproteins (hnRNPs) are central regulators of several fundamental biological processes across eukaryotes. hnRNPs have been…”
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