Engineering Functional Cardiac Tissues for Regenerative Medicine Applications

Purpose of Review Tissue engineering has expanded into a highly versatile manufacturing landscape that holds great promise for advancing cardiovascular regenerative medicine. In this review, we provide a summary of the current state-of-the-art bioengineering technologies used to create functional ca...

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Bibliographic Details
Published in:	Current cardiology reports Vol. 21; no. 9; p. 105
Main Authors:	Tomov, Martin L., Gil, Carmen J., Cetnar, Alexander, Theus, Andrea S., Lima, Bryanna J., Nish, Joy E., Bauser-Heaton, Holly D., Serpooshan, Vahid
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-08-2019
Subjects:	Biocompatible Materials - administration & dosage Bioprinting Cardiology Cell- and Tissue-Based Therapy - methods Heart - physiology Humans Medicine Medicine & Public Health Myocardium - cytology Myocytes, Cardiac - physiology Printing, Three-Dimensional Regenerative Medicine (SM Wu Regenerative Medicine - methods Regenerative Medicine - trends Section Editor Tissue Engineering - methods Tissue Engineering - trends Tissue Scaffolds Topical Collection on Regenerative Medicine Translational Research, Biomedical Vascular network Bioprinting 3D modeling Patient-specific precision medicine Cardiovascular regenerative medicine Cardiac tissue engineering
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Summary:	Purpose of Review Tissue engineering has expanded into a highly versatile manufacturing landscape that holds great promise for advancing cardiovascular regenerative medicine. In this review, we provide a summary of the current state-of-the-art bioengineering technologies used to create functional cardiac tissues for a variety of applications in vitro and in vivo. Recent Findings Studies over the past few years have made a strong case that tissue engineering is one of the major driving forces behind the accelerating fields of patient-specific regenerative medicine, precision medicine, compound screening, and disease modeling. To date, a variety of approaches have been used to bioengineer functional cardiac constructs, including biomaterial-based, cell-based, and hybrid (using cells and biomaterials) approaches. While some major progress has been made using cellular approaches, with multiple ongoing clinical trials, cell-free cardiac tissue engineering approaches have also accomplished multiple breakthroughs, although drawbacks remain. Summary This review summarizes the most promising methods that have been employed to generate cardiovascular tissue constructs for basic science or clinical applications. Further, we outline the strengths and challenges that are inherent to this field as a whole and for each highlighted technology.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1523-3782 1534-3170
DOI:	10.1007/s11886-019-1178-9