Search Results - "Nisar, Muhammad Imran"
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Identification of potential therapeutic intervening targets by in-silico analysis of nsSNPs in preterm birth-related genes
Published in PloS one (07-03-2023)“…Prematurity is the foremost cause of death in children under 5 years of age. Genetics contributes to 25-40% of all preterm births (PTB) yet we still need to…”
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Substitution spectra of SARS-CoV-2 genome from Pakistan reveals insights into the evolution of variants across the pandemic
Published in Scientific reports (28-11-2023)“…Changing morbidity and mortality due to COVID-19 across the pandemic has been linked with factors such as the emergence of SARS-CoV-2 variants and vaccination…”
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Differential coverage for vaccines in the expanded program on immunization (EPI) among children in rural Pakistan
Published in Vaccine (17-04-2023)“…•Vaccine coverage and timeliness were low among children in Matiari, Pakistan.•48.4 % of the children were fully vaccinated with all EPI antigens.•Majority of…”
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Predictors of Respiratory Syncytial Virus, Influenza Virus, and Human Metapneumovirus Carriage in Children Under 5 Years With WHO‐Defined Fast‐Breathing Pneumonia in Pakistan
Published in Influenza and other respiratory viruses (01-04-2024)“…ABSTRACT Background Pneumonia is a leading cause of morbidity and mortality in children < 5 years. We describe nasopharyngeal carriage of respiratory syncytial…”
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Unveiling and addressing implementation barriers to routine immunization in the peri-urban slums of Karachi, Pakistan: a mixed-methods study
Published in Health research policy and systems (11-08-2021)“…Abstract Background Great disparities in immunization coverage exist in Pakistan between urban and rural areas. However, coverage estimates for large…”
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Disparities in age and gender-specific SARS-CoV-2 diagnostic testing trends: a retrospective study from Pakistan
Published in BMC public health (27-09-2024)“…Pakistan reported 1.57 million COVID-19 cases between 2020 and 2022, based on approximately 30.6 million SARS-CoV-2 RT-PCR (reverse-transcription polymerase…”
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Newborn weight nomograms in selected low and middle-income countries
Published in Scientific reports (29-08-2023)“…Growth impairment is common in low- and middle-income countries (LMIC) and may begin during early infancy, increasing morbidity and mortality. To ensure…”
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Sequential viral introductions and spread of BA.1 across Pakistan provinces during the Omicron wave
Published in BMC genomics (03-08-2023)“…COVID-19 waves caused by specific SARS-CoV-2 variants have occurred globally at different times. We focused on Omicron variants to understand the genomic…”
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Direct maternal morbidity and the risk of pregnancy-related deaths, stillbirths, and neonatal deaths in South Asia and sub-Saharan Africa: A population-based prospective cohort study in 8 countries
Published in PLoS medicine (28-06-2021)“…Maternal morbidity occurs several times more frequently than mortality, yet data on morbidity burden and its effect on maternal, foetal, and newborn outcomes…”
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Serial population-based serosurveys for COVID-19 in two neighbourhoods of Karachi, Pakistan
Published in International journal of infectious diseases (01-05-2021)“…•The prevalence of coronavirus disease 2019 is high in Karachi.•Most seropositive cases are reported to be asymptomatic.•Contact within households is linked…”
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Serotype-specific effectiveness against pneumococcal carriage and serotype replacement after ten-valent Pneumococcal Conjugate Vaccine (PCV10) introduction in Pakistan
Published in PloS one (01-01-2022)“…Pakistan was one of the first South-Asian countries to introduce the ten-valent pneumococcal conjugate vaccine (PCV10) at the national level, using a 3+0…”
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Neurodevelopmental outcomes following possible serious bacterial infection in early infancy in Karachi, Pakistan: a prospective cohort study
Published in BMC pediatrics (15-05-2024)“…Pakistan reports a significant burden of neonatal mortality, with infections as one of the major causes. We aim to assess the long-term impact of early infancy…”
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Cohort profile: the Pregnancy Risk Infant Surveillance and Measurement Alliance (PRISMA) – Pakistan
Published in BMJ open (10-12-2023)“…PurposePakistan has disproportionately high maternal and neonatal morbidity and mortality. There is a lack of detailed, population-representative data to…”
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Protocol for validation of the Global Scales for Early Development (GSED) for children under 3 years of age in seven countries
Published in BMJ open (24-01-2023)“…IntroductionChildren’s early development is affected by caregiving experiences, with lifelong health and well-being implications. Governments and civil…”
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Nutritional support for lactating women with or without azithromycin for infants compared to breastfeeding counseling alone in improving the 6-month growth outcomes among infants of peri-urban slums in Karachi, Pakistan—the protocol for a multiarm assessor-blinded randomized controlled trial (Mumta LW trial)
Published in Current controlled trials in cardiovascular medicine (01-09-2020)“…Abstract Background Globally, 45% of under-five deaths are either directly or indirectly attributable to malnutrition, and most of these deaths are in low- and…”
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Secondary attack rates and determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) household transmission in Pakistan: A case-ascertained prospective, longitudinal study
Published in Journal of infection and public health (01-05-2024)“…Households are considered ideal settings for studying the transmission dynamics of an infectious disease. A prospective study was conducted, based on the World…”
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Does the implementation of revised American College of Cardiology and American Heart Association (ACC/AHA) guidelines improve the identification of stillbirths and preterm births in hypertensive pregnancies: a population-based cohort study from South Asia and sub-Saharan Africa
Published in BMC pregnancy and childbirth (29-06-2024)“…Hypertensive disorders of pregnancy (HDP) are a significant cause of maternal mortality worldwide. The classification and treatment of hypertension in…”
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Knowledge, attitudes, and practices toward seasonal influenza vaccination among healthcare workers and pregnant women in Pakistan: A mixed methods approach
Published in Human vaccines & immunotherapeutics (01-08-2023)“…Vaccine hesitancy is a significant public health issue globally. We aim to document the barriers toward seasonal influenza vaccine uptake among healthcare…”
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Opportunities and challenges to non-communicable disease (NCD) research and training in Pakistan: a qualitative study from Pakistan
Published in BMJ open (19-12-2022)“…IntroductionMost of the global non-communicable disease (NCD)-related death burden is borne by low and middle-income countries (LMICs). In LMICs like Pakistan,…”
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Feasibility, usability and acceptability of paediatric lung ultrasound among healthcare providers and caregivers for the diagnosis of childhood pneumonia in resource-constrained settings: a qualitative study
Published in BMJ open (11-03-2021)“…ObjectivesPaediatric pneumonia burden and mortality are highest in low-income and middle-income countries (LMIC). Paediatric lung ultrasound (LUS) has emerged…”
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