Search Results - "Nisén, Harry"

Active surveillance versus initial surgery in the long-term management of Bosniak IIF–IV cystic renal masses by Luomala, Lassi, Rautiola, Juhana, Järvinen, Petrus, Mirtti, Tuomas, Nisén, Harry

“…There may be surgical overtreatment of complex cystic renal masses (CRM). Growing evidence supports active surveillance (AS) for the management for Bosniak…”
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Low nuclear expression of HIF‐hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence‐free survival in clear cell renal cell carcinoma by Luomala, Lassi, Mattila, Kalle, Vainio, Paula, Nisén, Harry, Pellinen, Teijo, Lohi, Jouni, Laajala, Teemu D., Järvinen, Petrus, Koskenniemi, Anna‐Riina, Jaakkola, Panu, Mirtti, Tuomas

“…Background Hypoxia inducible factors, HIF‐1α and HIF‐2α, and their main regulators, the prolyl hydroxylase domain proteins (PHDs), mediate cellular response to…”
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The tumor and plasma cytokine profiles of renal cell carcinoma patients by Lee, Moon Hee, Laajala, Essi, Kreutzman, Anna, Järvinen, Petrus, Nísen, Harry, Mirtti, Tuomas, Hollmén, Maija, Mustjoki, Satu

“…Renal cell carcinoma (RCC) accounts for 90% of all renal cancers and is considered highly immunogenic. Although many studies have reported the circulating…”
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T and NK cell abundance defines two distinct subgroups of renal cell carcinoma by Lee, Moon Hee, Järvinen, Petrus, Nísen, Harry, Brück, Oscar, Ilander, Mette, Uski, Ilona, Theodoropoulos, Jason, Kankainen, Matti, Mirtti, Tuomas, Mustjoki, Satu, Kreutzman, Anna

“…Renal cell carcinoma (RCC) is considered as an immunogenic cancer. Because not all patients respond to current immunotherapies, we aimed to investigate the…”
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Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo by Lindfors, Sonja, Polianskyte-Prause, Zydrune, Bouslama, Rim, Lehtonen, Eero, Mannerla, Miia, Nisen, Harry, Tienari, Jukka, Salmenkari, Hanne, Forsgård, Richard, Mirtti, Tuomas, Lehto, Markku, Groop, Per-Henrik, Lehtonen, Sanna

“…Aims/hypothesis Chronic low-grade inflammation with local upregulation of proinflammatory molecules plays a role in the progression of obesity-related renal…”
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Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity by Polianskyte-Prause, Zydrune, Tolvanen, Tuomas A., Lindfors, Sonja, Dumont, Vincent, Van, Mervi, Wang, Hong, Dash, Surjya N., Berg, Mika, Naams, Jette-Britt, Hautala, Laura C., Nisen, Harry, Mirtti, Tuomas, Groop, Per-Henrik, Wähälä, Kristiina, Tienari, Jukka, Lehtonen, Sanna

“…ABSTRACT Metformin, the first‐line drug to treat type 2 diabetes (T2D), inhibits mitochondrial glycerolphosphate dehydrogenase in the liver to suppress…”
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PACSIN2 accelerates nephrin trafficking and is up‐regulated in diabetic kidney disease by Dumont, Vincent, Tolvanen, Tuomas A., Kuusela, Sara, Wang, Hong, Nyman, Tuula A., Lindfors, Sonja, Tienari, Jukka, Nisen, Harry, Suetsugu, Shiro, Plomann, Markus, Kawachi, Hiroshi, Lehtonen, Sanna

“…ABSTRACT Nephrin is a core component of podocyte (glomerular epithelial cell) slit diaphragm and is required for kidney ultrafiltration. Down‐regulation or…”
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A three-feature prediction model for metastasis-free survival after surgery of localized clear cell renal cell carcinoma by Mattila, Kalle E., Laajala, Teemu D., Tornberg, Sara V., Kilpeläinen, Tuomas P., Vainio, Paula, Ettala, Otto, Boström, Peter J., Nisen, Harry, Elo, Laura L., Jaakkola, Panu M.

“…After surgery of localized renal cell carcinoma, over 20% of the patients will develop distant metastases. Our aim was to develop an easy-to-use prognostic…”
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PD52-07 MANAGEMENT AND LONG-TERM OUTCOME OF COMPLICATED RENAL CYSTS by Luomala, Lassi, Rautiola, Juhana, Järvinen, Petrus, Mirtti, Tuomas, Nisén, Harry

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Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids by Hamdan, Firas, Ylösmäki, Erkko, Chiaro, Jacopo, Giannoula, Yvonne, Long, Maeve, Fusciello, Manlio, Feola, Sara, Martins, Beatriz, Feodoroff, Michaela, Antignani, Gabriella, Russo, Salvatore, Kari, Otto, Lee, Moon Hee, Järvinen, Petrus, Nisen, Harry, Kreutzman, Anna, Leusen, Jeanette, Mustjoki, Satu, McWilliams, Thomas G, Grönholm, Mikaela, Cerullo, Vincenzo

“…BackgroundDespite the success of immune checkpoint inhibitors against PD-L1 in the clinic, only a fraction of patients benefit from such therapy. A theoretical…”
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Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition by Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Santos, Joao Manuel, Havunen, Riikka, Zafar, Sadia, Hemminki, Otto, Heiniö, Camilla, Munaro, Eleonora, Siurala, Mikko, Sorsa, Suvi, Mirtti, Tuomas, Järvinen, Petrus, Mildh, Markus, Nisen, Harry, Rannikko, Antti, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli

“…Checkpoint inhibitors have revolutionized cancer therapy and validated immunotherapy as an approach. Unfortunately, responses are seen in a minority of…”
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Immunologic Characterization and T cell Receptor Repertoires of Expanded Tumor-infiltrating Lymphocytes in Patients with Renal Cell Carcinoma by Lee, Moon Hee, Theodoropoulos, Jason, Huuhtanen, Jani, Bhattacharya, Dipabarna, Järvinen, Petrus, Tornberg, Sara, Nísen, Harry, Mirtti, Tuomas, Uski, Ilona, Kumari, Anita, Peltonen, Karita, Draghi, Arianna, Donia, Marco, Kreutzman, Anna, Mustjoki, Satu

“…The successful use of expanded tumor-infiltrating lymphocytes (TIL) in adoptive TIL therapies has been reported, but the effects of the TIL expansion,…”
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Phosphorylation of PACSIN2 at S313 Regulates Podocyte Architecture in Coordination with N-WASP by Bouslama, Rim, Dumont, Vincent, Lindfors, Sonja, Paavolainen, Lassi, Tienari, Jukka, Nisen, Harry, Mirtti, Tuomas, Saleem, Moin A, Gordin, Daniel, Groop, Per-Henrik, Suetsugu, Shiro, Lehtonen, Sanna

“…Changes in the dynamic architecture of podocytes, the glomerular epithelial cells, lead to kidney dysfunction. Previous studies on protein kinase C and casein…”
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Abstract 3854: Precision medicine approach: analysis of renal cancer patient-derived cells with phenomics, genomics and drug sensitivity profiling by Pietiäinen, Vilja M., Mikkonen, Piia, Saeed, Khalid, Paavolainen, Lassi, Pellinen, Teijo, Potdar, Swapnil, Mpindi, John, Nisén, Harry, Rannikko, Antti, Mirtti, Tuomas, Horvath, Peter, Östling, Päivi, Kallioniemi, Olli

“…Abstract We have built up the precision medicine approach for solid tumors to understand biological heterogeneity and driver signalling pathways in cancer, to…”
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Abstract 1867: Characterization in patient derived tumor organoids of novel oncolytic adenoviruses expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitors by Hamdan, Firas, Ylösmäki, Erkko, Chiaro, Jacopo, Giannoula, Yvonne, Long, Maeve, Fusciello, Manlio, Feola, Sara, Martins, Beatriz, Feodoroff, Michaela, Antignani, Gabriella, Kari, Otto, Lee, Moon Hee, Järvinen, Petrus, Nisen, Harry, Kreutzman, Anna, Mustjoki, Satu, McWilliams, Thomas G, Grönholm, Mikaela, Cerullo, Vincenzo

“…Abstract Despite the success of immune checkpoint inhibitors in the clinic, they only benefit a fraction of patients. A theoretical strategy to increase…”
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Clonal heterogeneity influences drug responsiveness in renal cancer assessed by ex vivo drug testing of multiple patient‐derived cancer cells by Saeed, Khalid, Ojamies, Poojitha, Pellinen, Teijo, Eldfors, Samuli, Turkki, Riku, Lundin, Johan, Järvinen, Petrus, Nisen, Harry, Taari, Kimmo, af Hällström, Taija M., Rannikko, Antti, Mirtti, Tuomas, Kallioniemi, Olli, Östling, Päivi

“…Renal cell cancer (RCC) has become a prototype example of the extensive intratumor heterogeneity and clonal evolution of human cancers. However, there is…”
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MP49-10 IMPACT OF SURGICAL APPROACH (OPEN VS. MINIMALLY INVASIVE) ON ONCOLOGICAL OUTCOMES AFTER NEPHRECTOMY FOR LOCALISED RENAL CELL CARCINOMA: A RECUR DATABASE PROJECT by Fallara, Giuseppe, Larcher, Alessandro, Dabestani, Saeed, Fossati, Nicola, Järvinen, Petrus, Nisen, Harry, Gudmundsson, Eirikur, Lam, Thomas B., Marconi, Lorenzo, Fernandéz-Pello, Sergio, Meijer, Richard P., Volpe, Alessandro, Beisland, Christian, Klatte, Tobias, Stewart, Grant D., Ljungberg, Börje, Montorsi, Francesco, Bex, Axel, Capitanio, Umberto

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Should patients with low‐risk renal cell carcinoma be followed differently after nephron‐sparing surgery vs radical nephrectomy? by Abu‐Ghanem, Yasmin, Powles, Thomas, Capitanio, Umberto, Beisland, Christian, Järvinen, Petrus, Stewart, Grant D., Gudmundsson, Eirikur, Lam, Thomas B.L., Marconi, Lorenzo, Fernandéz‐Pello, Sergio, Nisen, Harry, Meijer, Richard P., Volpe, Alessandro, Ljungberg, Börje, Klatte, Tobias, Bensalah, Karim, Dabestani, Saeed, Bex, Axel

“…Objective To investigate whether pT1 renal cell carcinoma (RCC) should be followed differently after partial (PN) or radical nephrectomy (RN) based on a…”
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The Impact of Histological Subtype on the Incidence, Timing, and Patterns of Recurrence in Patients with Renal Cell Carcinoma After Surgery—Results from RECUR Consortium by Abu-Ghanem, Yasmin, Powles, Thomas, Capitanio, Umberto, Beisland, Christian, Järvinen, Petrus, Stewart, Grant D., Gudmundsson, Eiríkur Orri, Lam, Thomas B., Marconi, Lorenzo, Fernandéz-Pello, Sergio, Nisen, Harry, Meijer, Richard P., Volpe, Alessandro, Ljungberg, Börje, Klatte, Tobias, Dabestani, Saeed, Bex, Axel

“…Current follow-up strategies for patients with renal cell carcinoma (RCC) after curative surgery rely mainly on risk models and the treatment delivered,…”
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Recurrence pattern in localized RCC: results from a European multicenter database (RECUR) by Fallara, Giuseppe, Larcher, Alessandro, Dabestani, Saeed, Fossati, Nicola, Järvinen, Petrus, Nisen, Harry, Gudmundsson, Eirikur, Lam, Thomas B., Marconi, Lorenzo, Fernandéz-Pello, Sergio, Meijer, Richard P., Volpe, Alessandro, Beisland, Christian, Klatte, Tobias, Stewart, Grant D., Bensalah, Karim, Ljungberg, Börje, Bertini, Roberto, Montorsi, Francesco, Bex, Axel, Capitanio, Umberto

“…•Metastatic pattern after surgery for renal cancer can be affected by the choice of surgical technique.•There were no statistically significant differences…”
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