Search Results - "Nirschl, Jeffrey"

LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes by Fu, Meng-meng, Nirschl, Jeffrey J., Holzbaur, Erika L.F.

“…Autophagy is essential for maintaining cellular homeostasis in neurons, where autophagosomes undergo robust unidirectional retrograde transport along axons. We…”
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Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons by Gopal, Pallavi P., Nirschl, Jeffrey J., Klinman, Eva, Holzbaur, Erika L. F.

“…Ribonucleoprotein (RNP) granules are enriched in specific RNAs and RNA-binding proteins (RBPs) and mediate critical cellular processes. Purified RBPs form…”
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α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons by Nirschl, Jeffrey J., Magiera, Maria M., Lazarus, Jacob E., Janke, Carsten, Holzbaur, Erika L.F.

“…Motor-cargo recruitment to microtubules is often the rate-limiting step of intracellular transport, and defects in this recruitment can cause neurodegenerative…”
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A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue by Nirschl, Jeffrey J, Janowczyk, Andrew, Peyster, Eliot G, Frank, Renee, Margulies, Kenneth B, Feldman, Michael D, Madabhushi, Anant

“…Over 26 million people worldwide suffer from heart failure annually. When the cause of heart failure cannot be identified, endomyocardial biopsy (EMB)…”
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Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse by Guedes-Dias, Pedro, Nirschl, Jeffrey J., Abreu, Nohely, Tokito, Mariko K., Janke, Carsten, Magiera, Maria M., Holzbaur, Erika L.F.

“…Neurons in the CNS establish thousands of en passant synapses along their axons. Robust neurotransmission depends on the replenishment of synaptic components…”
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The impact of cytoskeletal organization on the local regulation of neuronal transport by Nirschl, Jeffrey J., Ghiretti, Amy E., Holzbaur, Erika L. F.

“…Key Points The neuronal cytoskeleton is functionally specialized within distinct compartments; local differences in cytoskeletal organization regulate local…”
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Actin cables and comet tails organize mitochondrial networks in mitosis by Moore, Andrew S., Coscia, Stephen M., Simpson, Cory L., Ortega, Fabian E., Wait, Eric C., Heddleston, John M., Nirschl, Jeffrey J., Obara, Christopher J., Guedes-Dias, Pedro, Boecker, C. Alexander, Chew, Teng-Leong, Theriot, Julie A., Lippincott-Schwartz, Jennifer, Holzbaur, Erika L. F.

“…Symmetric cell division requires the even partitioning of genetic information and cytoplasmic contents between daughter cells. Whereas the mechanisms…”
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The development and convergence of co-pathologies in Alzheimer's disease by Robinson, John L, Richardson, Hayley, Xie, Sharon X, Suh, EunRan, Van Deerlin, Vivianna M, Alfaro, Brian, Loh, Nicholas, Porras-Paniagua, Matias, Nirschl, Jeffrey J, Wolk, David, Lee, Virginia M-Y, Lee, Edward B, Trojanowski, John Q

“…Cerebral amyloid angiopathy (CAA), limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) and Lewy bodies occur in the absence…”
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Orientation-invariant autoencoders learn robust representations for shape profiling of cells and organelles by Burgess, James, Nirschl, Jeffrey J., Zanellati, Maria-Clara, Lozano, Alejandro, Cohen, Sarah, Yeung-Levy, Serena

“…Cell and organelle shape are driven by diverse genetic and environmental factors and thus accurate quantification of cellular morphology is essential to…”
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Creatine transport and pathological changes in creatine transporter deficient mice by Wawro, Adam M., Gajera, Chandresh R., Baker, Steven A., Nirschl, Jeffrey J., Vogel, Hannes, Montine, Thomas J.

“…The severe impact on brain function and lack of effective therapy for patients with creatine (Cr) transporter deficiency motivated the generation of three…”
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A rare neuromyelitis optica mimic: Primary CNS histiocytic sarcoma by Rogawski, David S, Nirschl, Jeffrey J, McDonald, Jamie, Nie, Esther, Schwartz, Nicholas U, Vogel, Hannes, Scott, Brian J, Gold, Carl A, Kipp, Lucas B

“…Primary central nervous system (CNS) histiocytic sarcoma is a rare hematolymphoid malignancy with features of mature histiocytes and carries a poor prognosis…”
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Rapid Deployment of Whole Slide Imaging for Primary Diagnosis in Surgical Pathology at Stanford Medicine: Responding to Challenges of the COVID-19 Pandemic by Rojansky, Rebecca, Jhun, Iny, Dussaq, Alex M, Chirieleison, Steven M, Nirschl, Jeffrey J, Born, Don, Fralick, Jennifer, Hetherington, William, Kerr, Alison M, Lavezo, Jonathan, Lawrence, Daniel B, Lummus, Seth, Macasaet, Ronald, Montine, Thomas J, Ryan, Emily, Shen, Jeanne, Shoemaker, Jonathan, Tan, Brent, Vogel, Hannes, Waraich, Puneet Singh, Yang, Eric, Young, April, Folkins, Ann

“…Stanford Pathology began stepwise subspecialty implementation of whole slide imaging (WSI) in 2018 soon after the first US Food and Drug Administration…”
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A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H E tissue by Jeffrey J Nirschl, Andrew Janowczyk, Eliot G Peyster, Renee Frank, Kenneth B Margulies, Michael D Feldman, Anant Madabhushi

“…Over 26 million people worldwide suffer from heart failure annually. When the cause of heart failure cannot be identified, endomyocardial biopsy (EMB)…”
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TDP43 pathology in chronic traumatic encephalopathy retinas by Phansalkar, Ragini, Goodwill, Vanessa S, Nirschl, Jeffrey J, De Lillo, Chiara, Choi, Jihee, Spurlock, Elizabeth, Coughlin, David G, Pizzo, Donald, Sigurdson, Christina J, Hiniker, Annie, Alvarez, Victor E, Mckee, Ann C, Lin, Jonathan H

“…Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by…”
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Lipid Rafts Assemble Dynein Ensembles by Nirschl, Jeffrey J., Ghiretti, Amy E., Holzbaur, Erika L.F.

“…New work by Rai et al. identifies a novel mechanism regulating phagosome transport in cells: the clustering of dynein motors into lipid microdomains, leading…”
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CDC42BPA::BRAF represents a novel fusion in desmoplastic infantile ganglioglioma/desmoplastic infantile astrocytoma by Barros Guinle, Maria Isabel, Nirschl, Jeffrey J, Xing, Yao Lulu, Nettnin, Ella A, Arana, Sophia, Feng, Zhi-Ping, Nasajpour, Emon, Pronina, Anna, Garcia, Cesar A, Grant, Gerald A, Vogel, Hannes, Yeom, Kristen W, Prolo, Laura M, Petritsch, Claudia K

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Live-cell imaging of retrograde transport initiation in primary neurons by Nirschl, Jeffrey J, Holzbaur, Erika L F

“…Axonal transport is an essential function in neurons, as mutations in either motor proteins or their adaptors cause neurodegeneration. While some mutations…”
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A Rare Neuromyelitis Optica Mimic: Primary CNS Histiocytic Sarcoma by Rogawski, David, Nirschl, Jeffrey, McDonald, Jamie, Nie, Esther, Schwartz, Nicholas, Vogel, Hannes, Scott, Brian, Gold, Carl, Kipp, Lucas

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PATH-54. CDC42BPA::BRAF REPRESENTS A NOVEL FUSION IN DESMOPLASTIC INFANTILE GLIOMA by Guinle, Maria Isabel Barros, Nettnin, Ella A, Nasajpour, Emon, Nirschl, Jeffrey, Garcia, Cesar A, Vogel, Hannes, Yeom, Kristen, Prolo, Laura, Petritsch, Claudia

“…Abstract Desmoplastic infantile ganglioglioma/desmoplastic infantile astrocytomas (DIG/DIA), although rare, are low-grade glioneuronal tumors that typically…”
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CNSC-25. CONCURRENT IMMUNE CHECKPOINT BLOCKADE ENHANCES THE SURVIVAL BENEFIT OF CLINICALLY RELEVANT MAPK PATHWAY INHIBITORS IN A T CELL-DEPENDENT MANNER by Xing, Yao Lulu, Park, Jong-Whi, Grossauer, Stefan, Panovska, Dena, Bui, Brandon, Morales, Daniella, Nirschl, Jeffrey, Feng, Zhi-Ping, Anderson, Wes, Levy, Jean Mulcahy, Schreck, Karisa, Prolo, Laura, Hambardzymyan, Dolores, Petritsch, Claudia

“…Abstract BACKGROUND Despite the availability of targeted therapies, gliomas carrying the BRAFV600E mutation remain challenging to treat. Combined pharmacologic…”
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