Search Results - "Nirenberg, Marshall"

Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory by Xia, Menghang, Huang, Ruili, Guo, Vicky, Southall, Noel, Cho, Ming-Hsuang, Inglese, James, Austin, Christopher P, Nirenberg, Marshall

“…Many studies have implicated the cAMP Response Element Binding (CREB) protein signaling pathway in long-term memory. To identify small molecule enhancers of…”
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RNA interference screen to identify genes required for Drosophila embryonic nervous system development by Koizumi, Keita, Higashida, Haruhiro, Yoo, Siuk, Islam, Mohamad Saharul, Ivanov, Andrej I, Guo, Vicky, Pozzi, Paola, Yu, Shu-Hua, Rovescalli, Alessandra C, Tang, Derek, Nirenberg, Marshall

“…RNA interference (RNAi) has been shown to be a powerful method to study the function of genes in vivo by silencing endogenous mRNA with double-stranded (ds)…”
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A Functional Genomic Screen for Cardiogenic Genes Using RNA Interference in Developing Drosophila Embryos by Kim, Yong-Ou, Park, Sang-Joon, Balaban, Robert S., Nirenberg, Marshall, Kim, Yongsok

“…Identifying genetic components is an essential step toward understanding complex developmental processes. The primitive heart of the fruit fly, the dorsal…”
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Silencing of genes in cultured Drosophila neurons by RNA interference by Sharma, Shail K, Nirenberg, Marshall

“…Cultures of neuroblasts that generate abundant neurons were established from Drosophila embryos to study silencing of genes by RNA interference (RNAi)…”
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Mapping Activation and Repression Domains of the vnd/NK-2 Homeodomain Protein by Stepchenko, Alexander, Nirenberg, Marshall

“…A transient transfection assay using Drosophila S2 tissue culture cells and WT and mutant Drosophila vnd/NK-2 homeobox cDNAs was used to localize repression…”
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Identification of a potent new chemotype for the selective inhibition of PDE4 by Skoumbourdis, Amanda P., Huang, Ruili, Southall, Noel, Leister, William, Guo, Vicky, Cho, Ming-Hsuang, Inglese, James, Nirenberg, Marshall, Austin, Christopher P., Xia, Menghang, Thomas, Craig J.

“…A series of substituted 3,6-diphenyl-7 H-[1,2,4]triazolo[3,4- b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4)…”
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Genes required for Drosophila nervous system development identified by RNA interference by Ivanov, A.I, Rovescalli, A.C, Pozzi, P, Yoo, S, Mozer, B, Li, H.P, Yu, S.H, Higashida, H, Guo, V, Spencer, M

“…RNA interference was used to screen 3,314 Drosophila double-stranded RNAs, corresponding to approximately equal to 25% of Drosophila genes, for genes that…”
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Identification and analysis of vnd/NK-2 homeodomain binding sites in genomic DNA by Wang, L.H, Chmelik, R, Tang, D, Nirenberg, M

“…Vnd/NK-2 homeodomain affinity column chromatography was used to purify Drosophila DNA fragments bound by the vnd/NK-2 homeodomain. Sequencing the selected…”
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Sequence-Specific DNA Binding by the vnd/NK-2 Homeodomain of Drosophila by Wang, Lan-Hsiang, Chmelik, Rebecca, Nirenberg, Marshall

“…The ventral nervous system defective (vnd)/NK-2 homeodomain and some flanking amino acid residues were expressed in Escherichia coli, purified to homogeneity,…”
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Mutations That Affect the Ability of the vnd/NK-2 Homeoprotein to Regulate Gene Expression: Transgenic Alterations and Tertiary Structure by Koizumi, Keita, Lintas, Carla, Nirenberg, Marshall, Maeng, Jin-Soo, Ju, Jeong-Ho, Mack, James W., Gruschus, James M., Odenwald, Ward F., Ferretti, James A.

“…The importance in downstream target regulation of tertiary structure and DNA binding specificity of the protein encoded by the vnd/NK-2 homeobox gene is…”
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Regulatory DNA Required for vnd/NK-2 Homeobox Gene Expression Pattern in Neuroblasts by Shao, Xiaoping, Koizumi, Keita, Nosworthy, Neil, Tan, Dong-Ping, Odenwald, Ward, Nirenberg, Marshall

“…Vnd/NK-2 protein was detected in 11 neuroblasts per hemisegment in Drosophila embryos, 9 medial and 2 intermediate neuroblasts. Fragments of DNA from the…”
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Mouse Sebox Homeobox Gene Expression in Skin, Brain, Oocytes, and Two-Cell Embryos by Cinquanta, Mario, Rovescalli, Alessandra C., Kozak, Christine A., Nirenberg, Marshall

“…Sebox is a mouse paired-like homeobox gene, previously named OG-9. Sebox genomic DNA and cDNA were cloned and sequenced. In addition, rat and human Sebox…”
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Historical review: Deciphering the genetic code – a personal account by Nirenberg, Marshall

“…This is an autobiographical description of the events that led to the breaking of the genetic code and the subsequent race to decipher the code. The code was…”
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Structural Basis of an Embryonically Lethal Single Ala → Thr Mutation in the vnd/NK-2 Homeodomain by Xiang, Bosong, Weiler, Solly, Nirenberg, Marshall, Ferretti, James A.

“…The structural and DNA binding behavior is described for an analog of the vnd/NK-2 homeodomain, which contains a single amino acid residue alanine to threonine…”
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The Mouse Nkx-1.2 Homeobox Gene: Alternative RNA Splicing at Canonical and Noncanonical Splice Sites by Rovescalli, Alessandra Cecilia, Cinquanta, Mario, Ferrante, Jacqueline, Kozak, Christine A., Nirenberg, Marshall

“…A mouse homeobox gene, Nkx-1.2, (previously termed Sax-1) that is closely related to the Drosophila NK-1/S59 gene was cloned, and genomic DNA and cDNA were…”
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Kinesin-73 in the nervous system of Drosophila embryos by Li, H.P. (National Institutes of Health, Bethesda, MD.), Liu, Z.M, Nirenberg, M

“…Kinesin-73 cDNA was shown to encode a kinesin heavy chain protein that contains an N-terminal motor domain and a long central region that lacks extensive…”
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Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells by Lum, Lawrence, Yao, Shenqin, Mozer, Brian, Rovescalli, Alessandra, Von Kessler, Doris, Nirenberg, Marshall, Beachy, Philip A.

“…Classical genetic screens can be limited by the selectivity of mutational targeting, the complexities of anatomically based phenotypic analysis, or…”
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Homeobox Gene Prx3 Expression in Rodent Brain and Extraneural Tissues by Hermien S. A. Van Schaick, Smidt, Marten P., Rovescalli, Alessandra Cecilia, Luijten, Mirjam, Arno A. M. Van Der Kleij, Asoh, Sadamitsu, Kozak, Christine A., Nirenberg, Marshall, Burbach, Peter H.

“…Different cDNA clones encoding a rat homeobox gene and the mouse homologue OG-12 were cloned from adult rat brain and mouse embryo mRNA, respectively. The…”
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The Genetic Revolution: The Importance of Flies and Worms by Nirenberg, Marshall

“…The revolution in molecular genetics has created tremendous opportunities to do research that surely will lead to fundamental advances in knowledge of normal…”
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Site-directed Mutations in the vnd/NK-2 Homeodomain by Weiler, Solly, Gruschus, James M., Tsao, Désirée H.H., Yu, Lei, Wang, Lan-Hsiang, Nirenberg, Marshall, Ferretti, James A.

“…Secondary structures, DNA binding properties, and thermal denaturation behavior of six site-directed mutant homeodomains encoded by the vnd/NK-2 gene from…”
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