Ocular complications in survivors of the Ebola outbreak in Guinea

Abstract Purpose The Ebola outbreak of 2013-2016 severely affected West Africa and resulted in 2544 deaths and 1270 survivors in Guinea, the country where it began. This Ebola virus was the Zaire strain of the virus family Filoviridae. In this outbreak the case fatality rate was about 67%. The survi...

Full description

Saved in:

Bibliographic Details
Published in:	American journal of ophthalmology Vol. 175; pp. 114 - 121
Main Authors:	Hereth He'bert, Esther, Oury Bah, Mamadou, E'tard, Jean François, Sow, Mamadou Saliou, Resnikoff, Serge, Fardeau, Christine, Toure', Abdoulaye, Niouma Ouendeno, Alexis, Sagno, Isaac Ceougna, March, Laura, Izard, Suzanne, Lama, Pierre Louis, Barry, Moumié, Delaporte, Eric
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2017 Elsevier Limited Elsevier Masson
Subjects:	Adolescent Adult Age Cataracts Child Child, Preschool Diagnostic Techniques, Ophthalmological Disease Outbreaks DNA, Viral - analysis Ebola virus Ebolavirus Ebolavirus - genetics Epidemics Eye Infections, Viral - diagnosis Eye Infections, Viral - epidemiology Eye Infections, Viral - etiology Female Filoviridae Follow-Up Studies Guinea - epidemiology Hemorrhagic Fever, Ebola - complications Hemorrhagic Fever, Ebola - epidemiology Human health and pathology Humans Incidence Inflammation Keratitis - diagnosis Keratitis - epidemiology Keratitis - etiology Life Sciences Male Mens health Middle Aged Ophthalmology Patients Prospective Studies Scleritis - diagnosis Scleritis - epidemiology Scleritis - etiology Sensory Organs Survivors Uveitis - diagnosis Uveitis - epidemiology Uveitis - etiology Young Adult
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Purpose The Ebola outbreak of 2013-2016 severely affected West Africa and resulted in 2544 deaths and 1270 survivors in Guinea, the country where it began. This Ebola virus was the Zaire strain of the virus family Filoviridae. In this outbreak the case fatality rate was about 67%. The survivors, declared cured after two negative blood PCR results, face psychosocial disorders, rheumatic, ear-nose-throat, neurocognitive, and ophthalmological complications. The goal of this study was to detect and describe ocular complications afflicting these survivors and to observe their occurrence and recurrences. Design prospective observational cohort study. Methods This prospective observational multicenter cohort study was initiated in March 2015. The cohort study included 341 survivors followed up in the infectious disease ward of Conakry, Forecariah and Nzérékoré as of May 2016. The patients received multidisciplinary medical follow-up expected to last at least one year that included an eye examination as part of complete free treatment. Results Systematic examination of 341 patients revealed 46 cases of uveitis (13.5%), six cases of episcleritis (1.8%), and three cases of interstitial keratitis (0.9%). Uveitis was most frequently unilateral (78.3%) and anterior (47.8%) and occurred within the 2 months following discharge from the Ebola treatment center. Moreover, uveitis relapses were found up to 13 months after the negative PCR result for Ebola in the blood. Conclusion Nearly 1 out of 6 survivors presented ocular disorders after discharge from the Ebola treatment center. An ophthalmological follow-up for Ebola-infected patients should start if possible during the acute phase of the disease and last more than one year. Treatment guidelines need to be urgently developed and implemented.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Undefined-2 ObjectType-Feature-2
ISSN:	0002-9394 1879-1891
DOI:	10.1016/j.ajo.2016.12.005