Search Results - "Nioi, P"

In Vitro Detection of Drug-Induced Phospholipidosis Using Gene Expression and Fluorescent Phospholipid–Based Methodologies by Nioi, Paul, Perry, Brad K., Wang, Er-Jia, Gu, Yi-Zhong, Snyder, Ronald D.

“…Phospholipidosis (PLD) is characterized by the excessive intracellular accumulation of phospholipids. It is well established that a large number of cationic…”
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P-48 Neurofilament light chain as a biomarker in hereditary transthyretin-mediated amyloidosis: 36-month data from the patisiran global open-label extension by Gilling, K., Aldinc, E., Ticau, S., Polydefkis, M., Adams, D., Reilly, M., Nioi, P.

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A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity by Nioi, Paul, Nguyen, Truyen

“…Keap1 is the substrate recognition module of a Cullin 3-based E3 ubiquitin ligase. Its primary role is to catalyze the ubiquitylation of the Nrf2 transcription…”
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The V122I mutation in hereditary transthyretin-mediated amyloidosis is significantly associated with an increased incidence of polyneuropathy by Parker, M.M, Damrauer, S.M, Erbe, D, Aldinc, E, Ticau, S, Flynn-Carroll, A, Deaton, A.M, Ward, L.D, Rader, D.J, Fitzgerald, K, Vaishnaw, A.K, Hinkle, G, Nioi, P

“…Abstract Background Hereditary transthyretin-mediated (hATTR) amyloidosis is a progressive, life-threatening disease caused by mutations in the transthyretin…”
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The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation by Nioi, Paul, Nguyen, Truyen, Sherratt, Philip J., Pickett, Cecil B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence by Nioi, Paul, McMahon, Michael, Itoh, Ken, Yamamoto, Masayuki, Hayes, John D

“…NQO1 [NAD(P)H:quinone oxidoreductase 1] has an integral role in cellular responses to oxidative stress. The expression of NQO1 is up-regulated in the mouse…”
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Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1 by Nguyen, Truyen, Sherratt, Philip J., Nioi, Paul, Yang, Chung S., Pickett, Cecil B.

“…Nrf2 regulates the expression of genes encoding antioxidant proteins involved in cellular redox homeostasis. Previous studies have suggested that activation of…”
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Comment on “Using Human ‘Experiments of Nature’ to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors” by Ward, Lucas D., Moffat, Graeme J., Yuan, Jing, Nioi, Paul

“…We read with interest the recent work by Jerome et al. using a phenome-wide association study (PheWAS) approach to predict potentially deleterious effects of…”
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Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors by Nioi, Paul, Hayes, John D

“…NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against reactive forms of oxygen and inhibition of neoplasia. Under conditions of…”
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