Search Results - "Ninniri, Maria Stefania S"

Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe by Tamayo, Nuria A, Bourbeau, Matthew P, Allen, Jennifer R, Ashton, Kate S, Chen, Jian Jeffrey, Kaller, Matthew R, Nguyen, Thomas T, Nishimura, Nobuko, Pettus, Liping H, Walton, Mary, Belmontes, Brian, Moriguchi, Jodi, Chen, Kui, McCarter, John D, Hanestad, Kelly, Chung, Grace, Ninniri, Maria Stefania S, Sun, Jan, Poppe, Leszek, Spahr, Chris, Hui, John, Jia, Lei, Wu, Tian, Dahal, Upendra P, Edson, Katheryne Z, Payton, Marc

“…Chromosomal instability (CIN) is a hallmark of cancer that results from errors in chromosome segregation during mitosis. Targeting of CIN-associated…”
Get full text

Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes by Payton, Marc, Cheung, Hung-Kam, Ninniri, Maria Stefania S, Marinaccio, Christian, Wayne, William C, Hanestad, Kelly, Crispino, John D, Juan, Gloria, Coxon, Angela

“…Aurora kinase A and B have essential and non-overlapping roles in mitosis, with elevated expression in a subset of human cancers, including acute myeloid…”
Get full text

Abstract 516: Discovery and preclinical characterization of AMG 650, a first-in-class inhibitor of kinesin KIF18A motor protein with potent activity against chromosomally unstable cancers by Belmontes, Brian, Moriguchi, Jodi, Chung, Grace, Sun, Jan, Ninniri, Maria Stefania S., Hanestad, Kelly, Chen, Kui, McCarter, John D., Dahal, Upendra P., Ghimire-Rijal, Sudipa, Hao, Yue, Mohr, Christopher P., Yu, Xinchao, Rees, Matthew G., Ronan, Melissa, Roth, Jennifer, Minocherhomji, Sheroy, Allen, Jennifer R., Bourbeau, Matthew P., Hughes, Paul E., Tamayo, Nuria A, Payton, Marc N.

“…Abstract Chromosomal instability (CIN) is a hallmark of human cancers and is caused by persistent errors in chromosome segregation during mitosis. Aggressive…”
Get full text