Search Results - "Ning, Changwen"

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates by O’Connor, Carrie, Wallace-Povirk, Adrianne, Ning, Changwen, Frühauf, Josephine, Tong, Nian, Gangjee, Aleem, Matherly, Larry H., Hou, Zhanjun

“…There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled…”
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Immune inhibitory receptor-mediated immune response, metabolic adaptation, and clinical characterization in patients with COVID-19 by An, Huaying, Yan, Congrui, Ma, Jun, Gong, Jiayuan, Gao, Fenghua, Ning, Changwen, Wang, Fei, Zhang, Meng, Li, Baoyi, Su, Yunqi, Liu, Pengyu, Wei, Hanqi, Jiang, Xingwei, Yu, Qun

“…Immune inhibitory receptors (IRs) play a critical role in the regulation of immune responses to various respiratory viral infections. However, in coronavirus…”
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Natural plant flavonoid apigenin directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration by He, Jing, Ning, Changwen, Wang, Yu, Ma, Tianfang, Huang, He, Ge, Yubin, Liu, Jingbo, Jiang, Yiqun

“…•Apigenin can be digested, released and absorbed into blood circulation to accumulate.•Apigenin directly inhibited Hsp90/Cdc37 interaction with structural…”
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Abstract 4791: Impact of folate transport redundancies on the therapy with tumor-targeted and untargeted antifolates by Hou, Zhanjun, O’Connor, Carrie, Ning, Changwen, Wallace-Povirk, Adrianne, Frühauf, Josephine, Nayeen, Md. Junayed, Gangjee, Aleem, Matherly, Larry H.

“…Abstract Folates participate in one-carbon (C1) transfer reactions in normal and cancer cells. Antifolate therapeutics disrupt cytosolic C1 metabolism, and…”
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Cellular Pharmacodynamics of a Novel Pyrrolo[3,2- d ]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism by Dekhne, Aamod S, Ning, Changwen, Nayeen, Md Junayed, Shah, Khushbu, Kalpage, Hasini, Frühauf, Josephine, Wallace-Povirk, Adrianne, O'Connor, Carrie, Hou, Zhanjun, Kim, Seongho, Hüttemann, Maik, Gangjee, Aleem, Matherly, Larry H

“…Folate-dependent one-carbon (C1) metabolism is compartmentalized in the mitochondria and cytosol and is a source of critical metabolites for proliferating…”
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Novel Pyrrolo[3,2- d ]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy by Dekhne, Aamod S, Shah, Khushbu, Ducker, Gregory S, Katinas, Jade M, Wong-Roushar, Jennifer, Nayeen, Md Junayed, Doshi, Arpit, Ning, Changwen, Bao, Xun, Frühauf, Josephine, Liu, Jenney, Wallace-Povirk, Adrianne, O'Connor, Carrie, Dzinic, Sijana H, White, Kathryn, Kushner, Juiwanna, Kim, Seongho, Hüttemann, Maik, Polin, Lisa, Rabinowitz, Joshua D, Li, Jing, Hou, Zhanjun, Dann, 3rd, Charles E, Gangjee, Aleem, Matherly, Larry H

“…Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid…”
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Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy by Dekhne, Aamod S, Shah, Khushbu, Ducker, Gregory S, Katinas, Jade M, Wong-Roushar, Jennifer, Nayeen, Md Junayed, Doshi, Arpit, Ning, Changwen, Bao, Xun, Frühauf, Josephine, Liu, Jenney, Wallace-Povirk, Adrianne, O'Connor, Carrie, Dzinic, Sijana H, White, Kathryn, Kushner, Juiwanna, Kim, Seongho, Hüttemann, Maik, Polin, Lisa, Rabinowitz, Joshua D, Li, Jing, Hou, Zhanjun, Dann, Charles E, Gangjee, Aleem, Matherly, Larry H

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Abstract 4794: Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2- d ]pyrimidine analogs by Ning, Changwen, Dekhne, Aamod, Nayeen, Md. Junayed, Katinas, Jade M., Wong, Jennifer, Frühauf, Josephine, Bao, Xun, O’Connor, Carrie, Wallace-Povirk, Adrianne, Li, Jing, Dann, Charles E., Gangjee, Aleem, Matherly, Larry H., Hou, Zhanjun

“…Abstract Pancreatic cancer (PaC) represents the 4th leading cause of cancer-related deaths in the US with a mortality rate of 99%. The 5-year overall survival…”
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Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer by Ning, Changwen, Liang, Min, Liu, Shuang, Wang, Guan, Edwards, Holly, Xia, Yang, Polin, Lisa, Dyson, Gregory, Taub, Jeffrey W, Mohammad, Ramzi M, Azmi, Asfar S, Zhao, Lijing, Ge, Yubin

“…Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease in urgent need of newer therapeutic modalities. Majority of patients with PDAC have mutations in…”
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Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2- d ]pyrimidine antifolates by Dekhne, Aamod, Shah, Khushbu, Ducker, Gregory S., Nayeen, Md. Junayed, Katinas, Jade M., Wong, Jennifer, Doshi, Arpit, Bao, Xun, Kalpage, Hasini, Liu, Jenney, Kim, Seongho, Wallace-Povirk, Adrianne, Ning, Changwen, O'Connor, Carrie, Hou, Zhanjun, Polin, Lisa, Li, Jing, Hüttemann, Maik, Rabinowitz, Joshua D., Dann, Charles E., Gangjee, Aleem, Matherly, Larry

“…Abstract Folate-dependent one-carbon metabolism (1CM) is compartmentalized in the mitochondria and cytosol and generates a number of metabolites critical to…”
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Novel Pyrrolo3,2-dpyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy by Dekhne, Aamod S, Shah, Khushbu, Ducker, Gregory S, Katinas, Jade M, Wong-Roushar, Jennifer, Nayeen, Md Junayed, Doshi, Arpit, Ning, Changwen, Bao, Xun, Frühauf, Josephine, Liu, Jenney, Wallace-Povirk, Adrianne, O'Connor, Carrie, Dzinic, Sijana H, White, Kathryn, Kushner, Juiwanna, Kim, Seongho, Hüttemann, Maik, Polin, Lisa, Rabinowitz, Joshua D, Li, Jing, Hou, Zhanjun, Dann, Charles E, Gangjee, Aleem, Matherly, Larry H

“…Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid…”
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