Search Results - "Nims, R.W."

Hand hygiene: virucidal efficacy of a liquid hand wash product against Ebola virus by Cutts, T.A., Nims, R.W., Theriault, S.S., Bruning, E., Rubino, J.R., Ijaz, M.K.

“…Hand washing is an important targeted hygiene intervention for limiting the spread of infectious agents, including the Ebola virus, which continues to…”
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Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent by Wink, D A, Osawa, Y, Darbyshire, J F, Jones, C R, Eshenaur, S C, Nims, R W

“…The effect of nitric oxide (NO) on cytochrome P450-mediated benzyloxyresorufin and ethoxyresorufin O-dealkylase activity of rat hepatic postmitochondrial (S-9)…”
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SARS-CoV-2 mutational variants may represent a new challenge to society, but not to the virucidal armamentarium by Ijaz, M.K., Nims, R.W., McKinney, J.

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Relative Potencies of Induction of Hepatic Drug-Metabolizing Enzyme Genes by Individual PCB Congeners by Dragnev, K.H., Nims, R.W., Fox, S.D., Lindahl, R., Lubet, R.A.

“…The induction of a variety of drug-metabolizing enzymes by polychlorinated biphenyl (PCB) congeners that elicit a 2,3,7,8,-tetrachlorodibenzo- p-dioxin…”
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Sensitivity of Isoenzyme Analysis for the Detection of Interspecies Cell Line Cross-Contamination by Nims, Raymond W., Adam P. Shoemaker, Marcie A. Bauernschub, Laura J. Rec, Harbell, John W.

“…The analysis of the gel electrophoresis banding patterns and relative migration distances for the individual isoforms of intracellular enzymes, such as lactate…”
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Direct measurement of the accumulation and mitochondrial conversion of nitric oxide within Chinese hamster ovary cells using an intracellular electron paramagnetic resonance technique by Clarkson, R.B., Norby, S.W., Smirnov, A., Boyer, S., Vahidi, N., Nims, R.W., Wink, D.A.

“…We have developed an electron paramagnetic resonance (EPR) method for the nondestructive detection and quantification of intracellular NO in real time. Based…”
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Metabolic conversion of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in the male F344/NCr rat by Fox, S.D, Roman, J.M, Issaq, H.J, Nims, R.W

“…1,1-Dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) and 1,1-dichloro-2, 2-bis(p-chlorophenyl)ethylene (DDE) levels were measured by capillary gas chromatography…”
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The induction of alkoxyresorufin metabolism: a potential indicator of environmental contamination by Lubet, R.A. (Laboratory of Comparative Carcinogenesis, Frederick Cancer Research Facility, Frederick, MD), Guengerich, F.P, Nims, R.W

“…Methods of biochemical monitoring of individual animals for exposure to environmental contaminants are of great potential use. The hepatic metabolism of…”
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Subchronic dietary exposure to Aroclor 1254 in rats: accumulation of PCBs in liver, blood, and adipose tissue and its relationship to induction of various hepatic drug-metabolizing enzymes by Dragnev, K H, Beebe, L E, Jones, C R, Fox, S D, Thomas, P E, Nims, R W, Lubet, R A

“…Female F344/NCr rats were exposed continuously (7-84 days) or discontinuously (7 days exposure/21 days control diet or 28 days exposure/56 days control diet)…”
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Accumulation and persistence of individual polychlorinated biphenyl congeners in liver, blood, and adipose tissue of rats following dietary exposure to Aroclor® 1254 by NIMS, R. W, FOX, S. D, ISSAQ, H. J, LUBET, R. A

“…Female F344/NCr rats were exposed continuously to Aroclor 1254 (1, 3.3, 10, 33, or 100 ppm in the diet) for 7, 28, or 84 days in order to assess the…”
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Induction of hepatic CYP1A activity as a biomarker for environmental exposure to Aroclor 1254 in feral rodents by Lubet, R.A. (Frederick Cancer Research and Development Center, Frederick, MD), Nims, R.W, Beebe, L.E, Fox, S.D, Issaq, H.J, McBee, K

“…Specimens of the feral mouse species Reithrodontomys fulvescens trapped from a polychlorinated biphenyl (PCB)-contaminated field location had hepatic…”
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Induction of hepatic CYP1A in male F344/NCr rats by dietary exposure to Aroclor 1254: examination of immunochemical, RNA, catalytic, and pharmacokinetic endpoints by Nims, R W, Beebe, L E, Dragnev, K H, Thomas, P E, Fox, S D, Issaq, H J, Jones, C R, Lubet, R A

“…Male F344/NCr rats were exposed to low dietary concentrations of Aroclor 1254 (0-33 ppm) for 7 days, following which the induction of selected hepatic drug…”
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Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine by Diwan, B A, Nims, R W, Ward, J M, Hu, H, Lubet, R A, Rice, J M

“…The ring hydrolysis products of the multi-tissue tumor promoting barbiturates, phenobarbital (PB) and barbital (BB), were fed to F344/NCr male rats previously…”
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Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes by Diwan, B A, Lubet, R A, Nims, R W, Klaunig, J E, Weghorst, C M, Henneman, J R, Ward, J M, Rice, J M

“…The tumor-promoting ability of clonazepam (CZP), a widely used benzodiazepine anticonvulsant, was investigated in an in vivo mouse liver tumor promotion assay…”
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Deuterium isotope effect on the toxicokinetics of monomethylamine in the rat by Streeter, A J, Nims, R W, Sheffels, P R, Hrabie, J A, Ohannesian, L, Heur, Y H, Mico, B A, Keefer, L K

“…The single-dose toxicokinetics of monomethylamine has been characterized in the rat by HPLC assay of serial blood samples. Biphasic first-order elimination was…”
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Influence of various parameters on benzo(a)pyrene enhancement of adenovirus SA7 transformation of Syrian hamster embryo cells by Lubet, R A, Nims, R W, Kiss, E, Kouri, R E, Putman, D L, Schechtman, L M

“…Several of the major variable factors in the Syrian hamster embryo/simian adenovirus SA7 (SHE/SA7) viral enhancement assay were identified and the effects of…”
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Analysis of the interlaboratory and intralaboratory reproducibility of the enhancement of simian adenovirus SA7 transformation of Syrian hamster embryo cells by model carcinogenic and noncarcinogenic compounds by Schechtman, L M, Hatch, G G, Anderson, T M, Putman, D L, Kouri, R E, Cameron, J W, Nims, R W, Spalding, J W, Tennant, R W, Lubet, R A

“…The intralaboratory and interlaboratory reproducibility of a DNA virus (SA7) transformation enhancement assay was investigated using nine carcinogenic and…”
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