Search Results - "Nimni, M E"

Polypeptide growth factors: targeted delivery systems by Nimni, M.E.

“…Growth factors are becoming extremely valuable tools in our attempts to understand the mechanisms that modulate cellular activities. Their targeting to…”
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Collagen types. Molecular structure and tissue distribution by Burgeson, R E, Nimni, M E

“…The collagens are products of a superfamily of closely related genes. Currently, there are 13 described collagens encompassing at least 25 separate genes. The…”
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Modulation of collagen synthesis by transforming growth factor-beta in keloid and hypertrophic scar fibroblasts by Younai, S, Nichter, L S, Wellisz, T, Reinisch, J, Nimni, M E, Tuan, T L

“…Keloid and hypertrophic scars are fibrous growths characterized by overabundant collagen deposition. We examined the effect of transforming growth factor-beta…”
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Selection and amplification of a bone marrow cell population and its induction to the chondro-osteogenic lineage by rhOP-1: an in vitro and in vivo study by Andrades, J A, Santamaría, J A, Nimni, M E, Becerra, J

“…The differentiation and maturation of osteoprogenitor cells into osteoblasts are processes which are thought to be modulated by transforming growth…”
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Engineering, Expression, and Renaturation of a Collagen-Targeted Human bFGF Fusion Protein by Andrades, J. A., Wu, L. T., Hall, F. L., Nimni, M. E., Becerra, J.

“…Abstract Basic fibroblast growth factor (bFGF) is a potent in vitro mitogen for capillary endothelial cells, stimulates angiogenesis in vivo, and may…”
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Relative distribution and crosslinking of collagen distinguish fetal from adult sheep wound repair by Lovvorn, Harold N, Cheung, David T, Nimni, Marcel E, Perelman, Natasha, Estes, James M, Adzick, N.Scott

“…Background/Purpose: Collagen deposition in midgestation fetal skin wounds occurs rapidly and in a normal reticular pattern unlike adult scar. Although collagen…”
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Cultures of ligament fibroblasts in fibrin matrix gel by Chun, Jacob, Tuan, T L, Han, Bo, Vangsness, C T, Nimni, M E

“…The cellular properties of anterior cruciate ligament (ACL) and medial collateral ligament (MCL) fibroblasts have been analyzed in a three-dimensional fibrin…”
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Biochemical composition of collagen in continent and stress urinary incontinent women by Bergman, A, Elia, G, Cheung, D, Perelman, N, Nimni, M E

“…This study was designed to assess the relationship between the amount of collagen type III in the pelvic supportive tissues and stress urinary incontinence…”
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Design, expression, and renaturation of a lesion-targeted recombinant epidermal growth factor-von Willebrand factor fusion protein: efficacy in an animal model of experimental colitis by Hall, F L, Kaiser, A, Liu, L, Chen, Z H, Hu, J, Nimni, M E, Beart, Jr, R W, Gordon, E M

“…In the present study, the mature epidermal growth factor (EGF) protein was engineered to incorporate a high affinity collagen-binding domain (CBD) derived from…”
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Demineralized bone matrix mediates differentiation of bone marrow stromal cells in vitro: Effect of age of cell donor by José, Becerra, Andrades, José A., Ertl, Delia C., Sorgente, Nino, Nimni, Marcel E.

“…Bone maintenance requires a continuous source of osteoblasts throughout life. Its remodeling and regeneration during fracture repair is ensured by…”
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Nitric oxide mediates hyperglycemia-induced defective migration in cultured endothelial cells by Gade, Prasad V., Andrades, José A., Nimni, Marcel E., Becerra, José, Longoria, James, Asemanfar, Nadereh, Sorgente, Nino

“…Purpose: To examine the effects of elevated glucose on the migration and proliferation of vascular endothelial cells in an in vitro wound model and to…”
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Dermal fibroblasts activate keratinocyte outgrowth on collagen gels by TAI-LAN TUAN, KELLER, L. C, SUN, D, NIMNI, M. E, CHEUNG, D

“…The effects of dermal fibroblasts on keratinocyte outgrowth on collagen substrata was studied using an in vitro keratinocyte-collagen gel composite model. Skin…”
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Delivery of Erythromycin to Subcutaneous Tissues in Rats by Means of a Trans-phase Delivery System by PENG, LYNNUS, NIMNI, MARCEL E.

“…Topical administration of antibiotics is associated with reduced risk of systemic side‐effects and alteration of gut microflora, and results in higher…”
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Role of growth factors in scar contraction: an in vitro analysis by Younai, S, Venters, G, Vu, S, Nichter, L, Nimni, M E, Tuan, T L

“…Excessive scar contracture by wound fibroblasts can have devastating consequences, ranging from body disfigurement to joint immobility. The ability of…”
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Production of a recombinant human basic fibroblast growth factor with a collagen binding domain by Andrades, J A, Santamaría, J A, Wu, L T, Hall, F L, Nimni, M E, Becerra, J

“…Basic fibroblast growth factor (bFGF) is a potent in vitro mitogen for capillary endothelial cells, stimulates angiogenesis in vivo, and may participate in…”
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Chondroitin sulfate and other sulfate containing chondroprotective agents may exhibit their effects by overcoming a deficiency of sulfur amino acids by Cordoba, F, Nimni, M.E

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The short-term therapeutic effect of recombinant human bone morphogenetic protein-2 on collagenase-induced lumbar facet joint osteoarthritis in rats by Yeh, T.-T., M.D, Wu, S.-S., M.D, Lee, C.-H., M.D, Wen, Z.-H., Ph.D, Lee, H.-S., M.D., Ph.D, Yang, Z., M.D, Nimni, M.E., Ph.D, Han, B., Ph.D

“…Summary Objective To determine whether an intra-articular injection of recombinant human bone morphogenetic protein-2 (rhBMP-2) alleviates cartilage…”
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Transdermal Delivery and Accumulation of Indomethacin in Subcutaneous Tissues in Rats by MIKULAK, STEPHEN A., VANGSNESS, C. THOMAS, NIMNI, MARCEL E.

“…Oral non‐steroidal anti‐inflammatory drugs (NSAIDs) are effective pharmacotherapy for a wide variety of painful, inflammatory disorders. Development of an…”
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Coordinate regulation of type IX and type II collagen synthesis during growth of chick chondrocytes in retinoic acid or 5-bromo-2'-deoxyuridine by Yasui, N, Benya, P D, Nimni, M E

“…Chondrocytes isolated from 15-day-old embryonic chick sterna were cultured as monolayers for 7 days in control medium or in medium supplemented with retinoic…”
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Postmortem degradation of demineralized bone matrix osteoinductive potential. Effect of time and storage temperature by Yazdi, M, Bernick, S, Paule, W J, Nimni, M E

“…The osteoinductive growth factors present in demineralized bone are degraded by tissue enzymes. Storage of rat limbs at low temperature (4 degrees C) before…”
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